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Osteogenesis promoter

An accelerator and osteogenesis technology, applied in anti-inflammatory agents, bone diseases, biological tests, etc., can solve problems such as bone mass increase, and achieve the effect of promoting bone formation and treating bone diseases

Active Publication Date: 2014-07-23
NAT UNIV CORP TOKYO MEDICAL & DENTAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, Non-Patent Document 8 revealed that semaphorin 4D was not detected in osteoblasts but was present on the surface of osteoclasts, and it was confirmed that female sema4D- / - mice with homozygous deletion of semaphorin 4D (Sema4D) In mice, bone mass was increased compared to wild-type mice

Method used

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Embodiment 1

[0093] [Analysis of mouse and bone phenotypes]

[0094]Sema4d- / -, Plxnb1- / -, Plexin B2 knockout (Plxnb2- / -), CAT-RhoA DN and α1(I)-Cre mice were prepared according to the methods described in the literature (W.Shi et al., Immunity13, 633 (November 2000), R.H. Friedel et al., J Neurosci27, 3921 (April 4, 2007), R.H. Friedel et al., Proc Natl Acad Sci U S A102, 13188 (September 13, 2005), K. Kobayashi et al., J Neurosci 24, 3480 (April 7, 2004), R. Dacquin, M. Starbuck, T. Schinke, G. Karsenty, Dev Dyn 224, 245 (June 2002). All mice were backcrossed more than 8 times with C57BL / 6 mice. All mice remained free of specific pathogens. All animal experiments were approved by the Animal Experiment Committee of Tokyo Medical and Dental University, in compliance with relevant guidelines and laws. For the bone phenotype, various genetically modified mice were used and their same-ventral mice were used as controls, and 8 males and 8 males were analyzed respectively. Three-dimensional ...

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Abstract

The purpose of the present invention is to provide an osteogenesis promoter for directly promoting osteogenesis by osteoblasts, and an agent for preventing and treating bone disease. The present invention is characterized in that a binding inhibitor substance of semaphorin 4D and plexin B1 is used. For the binding inhibitor substance, suitable examples include anti-semaphorin 4D antibody, anti-plexin B1 antibody, and protein comprising the extracellular domain of plexin B1.

Description

technical field [0001] The present invention relates to an osteogenesis-promoting agent and a preventive and therapeutic agent for bone diseases. More specifically, it relates to an osteogenesis-promoting agent and a preventive and therapeutic agent for bone diseases, which contain a binding inhibitor of semaphorin 4D and plexin B1 as an active ingredient. Background technique [0002] As society ages, the number of patients with orthopedic diseases such as fractures, osteoporosis, rheumatoid arthritis, and low back pain increases. In bone tissue, osteoblasts responsible for bone formation coordinate with osteoclasts responsible for bone resorption, and bone formation and bone resorption are performed in a good balance to maintain the function of bone tissue. The balance of this bone metabolism is out of balance due to factors such as aging and a decline in ovarian function. When bone formation is decreased or bone resorption is abnormally increased, bone mass (bone density...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K38/00A61K39/395A61P19/00A61P19/02A61P19/08A61P19/10A61P29/00A61P43/00G01N33/15G01N33/53C12N15/09
CPCA61K38/00A61K2039/505A61P19/00A61P19/02A61P19/08A61P19/10A61P29/00A61P43/00C07K16/2803G01N33/5008G01N2500/00G01N2800/10A61K39/395C07K16/28C07K16/2896G01N33/53
Inventor 高柳广根岸贵子
Owner NAT UNIV CORP TOKYO MEDICAL & DENTAL UNIV
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