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Gamma knife radiotherapy reverse design planning method

A radiation therapy and design method technology, applied in the computer field, can solve problems such as large collimator diameter, large dose distribution interaction, unsuitable body gamma knife, etc., and achieve the effect of improving genetic coding

Inactive Publication Date: 2014-07-30
BEIHANG UNIV
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Problems solved by technology

However, for the body gamma knife, the diameter of the collimator is larger, and the dose distribution between the targets with a closer distance has a greater influence on each other. Therefore, the optimization method based on geometric features is not suitable for the body gamma knife. Treatment Plan Design

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Embodiment Construction

[0036] The present invention will be further described below in conjunction with the accompanying drawings.

[0037] The present invention is a reverse plan design method for Gamma Knife radiotherapy, such as figure 1 As shown, the specific steps are as follows:

[0038] Step 1: Reconstruct the 3D model of the region of interest;

[0039] Reconstruct the three-dimensional model of the region of interest (ROI, Region of Interest) including the target area and the organ-at-risk area; and expand the target area in the ROI model to generate the target area edge outline (Margin). In order to increase the calculation speed, the present invention also performs sampling processing on the ROI three-dimensional model.

[0040] Step 2: Establish an optimization model;

[0041] The optimization goal is:

[0042] 1. Ensure the coverage of the dose in the target area;

[0043] 2. Improve the conformity of the dose in the target area;

[0044] 3. Reduce the dose to organs at risk;

[...

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Abstract

The invention discloses a gamma knife radiotherapy reverse design planning method. First, three-dimensional models of a target zone and endangered organ interest zones are reestablished; an optimization model is established; optimization parameters and genetic algorithm parameters are determined; and a graphics processing unit (GPU) is used for parallel computing for accelerating during the whole process, then solving is carried out according to an improved genetic algorithm, the process comprises initialization group gene coding, reproduction individual selecting by individual fitness calculating and accessing, individual reproduction variation group regeneration and weight adjusting, and finally a feasible treatment plan is obtained. The method has the advantages that the optimization model has good adaptability, the method can be suitable for different diseases by adjusting the weight in an objective function, according to the feature of gamma knife treatment plan designing, gene coding of the genetic algorithm, group initialization, reproduction and variation rules are improved, and according to the optimization model, a flexible effective individual fitness evaluation function is provided.

Description

technical field [0001] The invention relates to the field of computer technology, in particular to a reverse plan design method for gamma knife radiotherapy. Background technique [0002] Radiation therapy is one of the most important means of treating cancer. Gamma Knife radiation therapy uses gamma rays to irradiate cancerous tumor tissues to inhibit the growth, reproduction and spread of cancerous cells while minimizing damage to normal tissues. In order to achieve the purpose of treatment, the treatment plan is generally formulated through the treatment planning system (TPS) before the patient is treated, so that the dose in the target area has better coverage (Coverage) and conformity (Conformity); endangering organs (OAR) bear the lowest possible dose (Avoidance); at the same time, take into account the feasibility of the treatment plan. The traditional forward design of treatment plan is a process of continuous trial and error (trial and error): physicists design a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N5/10
Inventor 梁斌周付根刘博郭斌许轩昂
Owner BEIHANG UNIV
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