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A preparation method of β-cyclodextrin-immobilized cellulose membrane for chiral resolution of tryptophan

A technology of chiral separation and cellulose membrane, which is applied in the field of preparation of tryptophan chiral separation membrane, can solve problems such as the complexity of the preparation process, and achieve the effects of simplifying the preparation process, enhancing stability, and saving production costs

Active Publication Date: 2016-06-29
CHINA PHARM UNIV
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Problems solved by technology

Molecularly imprinted membranes have strong specificity. Each molecularly imprinted membrane can only resolve one chiral substance, and the preparation process is complicated.

Method used

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  • A preparation method of β-cyclodextrin-immobilized cellulose membrane for chiral resolution of tryptophan
  • A preparation method of β-cyclodextrin-immobilized cellulose membrane for chiral resolution of tryptophan
  • A preparation method of β-cyclodextrin-immobilized cellulose membrane for chiral resolution of tryptophan

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Embodiment Construction

[0006] Below in conjunction with implementation case, illustrate feature of the present invention:

[0007] Firstly, the β-cyclodextrin-immobilized cellulose membrane was prepared through the following steps, and then the resolution performance of the membrane was characterized and evaluated.

[0008] The steps for preparing β-cyclodextrin-immobilized cellulose membrane are as follows:

[0009] (1) Membrane pretreatment: soak a 0.22 μm cellulose filter membrane in 60 mL of pure water for 1 hour, pour out the pure water, and use the filter membrane for later use.

[0010] (2) Oxidation reaction: put the filter membrane into a beaker, add periodate solution (0.25mM, 5mL), and place it in a constant temperature shaker (25°C, 150r / min) for 2h.

[0011] (3) Cross-linking immobilization reaction: After shaking at a constant temperature for 2 hours, pour out the periodate solution in the beaker, wash it with pure water for 3 times, and put the spare sodium sulfate (0.7M), sulfuric a...

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Abstract

The invention provides a preparing method of a beta-cyclodextrin immobilized cellulose membrane used for tryptophan chiral separation. According to the preparing method, the cellulose membrane is selected to be used as a base membrane material due to the advantages that the molecular structure per se of the cellulose membrane has multiple active hydroxyls capable of being used for modification, in addition, the price is low, and the acquisition is easy. Beta-cyclodextrin is chemically bonded on the cellulose membrane with the bore diameter of 0.22[mu]m, and chiral separation membranes are prepared. Racemic tryptophan is used as a separation object; in addition, separation effects are expressed; after the multilayer filtering, the modified filter membrane almost achieves the complete separation on DL-tryptophan; and a D-tryptophan solution is obtained. The separation performance stability RSD of the chiral membranes in 12h reaches 3.4 percent, and the stability is good. The preparing method can be widely applied to the field of chemical medicine separation.

Description

technical field [0001] The invention relates to a preparation method for a chiral separation membrane of tryptophan. Through synthesis and loading, the membrane for chiral separation is prepared, which can be widely used in the separation field of chemical industry and medicine. technical background [0002] Membrane separation method is to use the specific separation functional sites contained in the membrane or outside the membrane to resolve the vortex mixture. The membrane separation method has the advantages of low energy consumption, simple operation, large batch capacity, easy continuous operation, easy industrial scale-up, flexible device design and system application, and room temperature operation in most cases. According to the morphology of the membrane, the membrane separation method can be divided into two types: liquid membrane separation and solid membrane separation. Chiral liquid membranes have a common disadvantage that is difficult to overcome, that is, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D71/10B01D67/00C07D209/20
Inventor 季一兵郝单单陈建秋
Owner CHINA PHARM UNIV
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