Mannitol injection

Abstract

The invention relates to the field of pharmaceutical preparations and particularly relates to a mannitol injection. The mannitol injection is prepared from mannitol, glycine, lecithin and water for injection, wherein the weight ratio of mannitol to glycine to lecithin is 10:3:1.

Description

technical field

[0001] The invention relates to the field of pharmaceutical preparations, in particular to a mannitol injection. Background technique

[0002] Intracranial pressure refers to the pressure generated by the contents of the cranial cavity on the wall of the cranial cavity, which is composed of two factors: hydrostatic pressure and vascular dynamic pressure. Since the total volume of the cranial cavity is relatively fixed, the intracranial pressure remains relatively stable. Normal supine intracranial pressure is about 1.33kPa (10mmHg). Intracranial hypertension is called intracranial hypertension when brain tissue swelling; intracranial space-occupying lesions; excessive secretion of cerebrospinal fluid, malabsorption, obstructed circulation, or excessive cerebral blood perfusion lead to intracranial pressure continuously maintained above 2.0kPa (15mmHg).

[0003] Mannitol injection is mainly used to treat cerebral edema and reduce intracranial pressure, and i...

Examples

Embodiment 1

[0026] Mannitol injection has the following components (by weight):

[0027] Mannitol 20%

[0028] Glycine 6%

[0029] Lecithin 2%

[0030] The balance is water for injection.

[0031] Preparation:

[0032] (1) Mix mannitol, glycine and lecithin with 1 / 3 weight of water for injection in proportion, add activated carbon, absorb, filter and decarbonize, and obtain a concentrated solution.

[0033] (2) Mix the above-mentioned concentrated solution with the remaining amount of water for injection, then add activated carbon for secondary adsorption, filter and decarbonize, and obtain a diluted solution.

[0034] (3) Filter the diluted solution in step (2) with a 0.22 μm filter, and fill it.

[0035] (4) Sterilize the injection obtained in step (3) at a temperature of 120-130° C. to obtain the mannitol injection of the present invention.

[0036] The amount of activated carbon added in the above preparation method is 0.02% (w / v), and the carbon removal is filtered with a 0.45 ...

technical field

[0001] The invention relates to the field of pharmaceutical preparations, in particular to a mannitol injection. Background technique

[0002] Intracranial pressure refers to the pressure generated by the contents of the cranial cavity on the wall of the cranial cavity, which is composed of two factors: hydrostatic pressure and vascular dynamic pressure. Since the total volume of the cranial cavity is relatively fixed, the intracranial pressure remains relatively stable. Normal supine intracranial pressure is about 1.33kPa (10mmHg). Intracranial hypertension is called intracranial hypertension when brain tissue swelling; intracranial space-occupying lesions; excessive secretion of cerebrospinal fluid, malabsorption, obstructed circulation, or excessive cerebral blood perfusion lead to intracranial pressure continuously maintained above 2.0kPa (15mmHg).

[0003] Mannitol injection is mainly used to treat cerebral edema and reduce intracranial pressure, and i...

Examples

Embodiment 1

[0026] Mannitol injection has the following components (by weight):

[0027] Mannitol 20%

[0028] Glycine 6%

[0029] Lecithin 2%

[0030] The balance is water for injection.

[0031] Preparation:

[0032] (1) Mix mannitol, glycine and lecithin with 1 / 3 weight of water for injection in proportion, add activated carbon, absorb, filter and decarbonize, and obtain a concentrated solution.

[0033] (2) Mix the above-mentioned concentrated solution with the remaining amount of water for injection, then add activated carbon for secondary adsorption, filter and decarbonize, and obtain a diluted solution.

[0034] (3) Filter the diluted solution in step (2) with a 0.22 μm filter, and fill it.

[0035] (4) Sterilize the injection obtained in step (3) at a temperature of 120-130° C. to obtain the mannitol injection of the present invention.

[0036] The amount of activated carbon added in the above preparation method is 0.02% (w / v), and the carbon removal is filtered with a 0.45 ...

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