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Composition having anti-depression effect as well as preparation method and use thereof

A composition and anti-depressant technology, applied in medical preparations containing active ingredients, drug combinations, pharmaceutical formulas, etc., can solve problems such as cardiovascular system damage, liver damage, and strong side effects

Active Publication Date: 2014-09-24
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these antidepressants have certain disadvantages, the most important manifestations are strong side effects, which are likely to cause cardiovascular system damage and liver damage, etc.

Method used

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  • Composition having anti-depression effect as well as preparation method and use thereof
  • Composition having anti-depression effect as well as preparation method and use thereof
  • Composition having anti-depression effect as well as preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0041] Experimental Example 1 Mouse Tail Suspension Test (TST) and Mouse Forced Swimming Test (FST)

[0042] 1.1 Animals:

[0043] Normal male ICR mice were purchased from Shanghai Xipuer-Bikay Experimental Animal Co., Ltd.

[0044] 1.2 Test substance:

[0045] Fluoxetine hydrochloride was purchased from Changzhou Siyao Pharmaceutical Co., Ltd., batch number 20131220.

[0046] Eleutheroside I, purchased from Hubei Jusheng Technology Co., Ltd.;

[0047] Salidroside I was purchased from Hubei Jusheng Technology Co., Ltd.

[0048] Eleutheroside II, prepared according to the second preparation method of the present invention;

[0049] Salidroside II is prepared according to the second preparation method of the present invention.

[0050] Eleutheroside III, prepared according to the third preparation method of the present invention;

[0051] Salidroside III is prepared according to the third preparation method of the present invention.

[0052] 1.3 Experimental grouping

[...

experiment example 2

[0078] Effect of Experimental Example 2 on Monoamine Neurotransmitters and Their Metabolites in Depressed Rats

[0079] 1.1 Animals:

[0080] Normal male rats, SPF grade, were purchased from Shanghai Xipuer-Bikay Experimental Animal Co., Ltd.

[0081] 1.2 Test substance:

[0082] Fluoxetine hydrochloride was purchased from Changzhou Siyao Pharmaceutical Co., Ltd., batch number 20131220.

[0083] Eleutheroside I, purchased from Hubei Jusheng Technology Co., Ltd.;

[0084] Salidroside I was purchased from Hubei Jusheng Technology Co., Ltd.

[0085] Eleutheroside II, prepared according to the second preparation method of the present invention;

[0086] Salidroside II is prepared according to the second preparation method of the present invention.

[0087] Eleutheroside III, prepared according to the third preparation method of the present invention;

[0088] Salidroside III is prepared according to the third preparation method of the present invention.

[0089] 1.3 Experim...

Embodiment 1

[0111] Example 1 tablet

[0112] Eleutheroside 3 Salidroside 5

[0113] The above-mentioned raw materials are commercially available, mixed according to the weight portion, added with appropriate amount of starch and magnesium stearate, granulated, sized and tabletted to obtain the product.

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Abstract

The invention relates to a composition having an anti-depression effect. The composition is composed of eleutheroside and salidroside in a weight ratio of (1-10): (1-10). The invention also discloses a preparation method of the composition. The composition can be applied to preparing anti-depression medicines.

Description

[0001] This application claims the priority of the Chinese patent application submitted to the China Patent Office on March 13, 2014, the application number is 201410102755.2, and the title of the invention is "a composition with antidepressant effect and its preparation method and use", all of which The contents are incorporated by reference in this application. technical field [0002] The invention belongs to the field of traditional Chinese medicine, in particular to a composition with antidepressant effect and its method and use Background technique [0003] Depression is a kind of depressive disorder characterized by low mood, which is mainly manifested as persistent low mood, slow thinking, and decreased volitional activity. The disease has the characteristics of high prevalence, high recurrence, high disability, and high medical costs, which seriously endanger human physical and mental health. The incidence rate of depression is very high, but its pathogenesis is st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/254A61P25/24A61K31/7032
Inventor 王永华萧伟李伯会王振中章晨峰于丹
Owner JIANGSU KANION PHARMA CO LTD
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