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A kind of Acanthopanax composition, preparation and detection method thereof

A technology of Acanthopanax senticosus and composition, which is applied in the field of pharmaceutical preparations and can solve problems such as the loss of active ingredients

Active Publication Date: 2019-06-14
HARBIN ZHENBAO PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method uses alcohol precipitation twice and macroporous adsorption resin to remove impurities, but it also causes the loss of active ingredients.

Method used

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  • A kind of Acanthopanax composition, preparation and detection method thereof
  • A kind of Acanthopanax composition, preparation and detection method thereof
  • A kind of Acanthopanax composition, preparation and detection method thereof

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Effect test

Embodiment 1

[0097] Embodiment 1 A kind of Acanthopanax composition and its preparation method and content determination

[0098] 1. Preparation method:

[0099] (1), pre-treatment: After cleaning and crushing 1000g Acanthopanax, add 6 times the volume of purified water to decoct for 2 hours, then separate the decoction; add 6 times the volume of purified water to decoct for 2 hours, separate the decoction; then Add 6 times the volume of ice, cool to room temperature, decoct for 2 hours, separate the decoction; add 6 times the volume of ice, cool to room temperature, decoct for 2 hours, separate the decoction; combine the decoction Liquid A is obtained;

[0100] (2) Calcium sulfur treatment: when the liquid A is cooled below 40°C, add 20% milk of lime by weight to it to adjust the pH value to 10.0, let it stand for 16 hours, and then use sulfuric acid to adjust the pH value to 5.0 , after stirring evenly, let it stand for 16 hours, filter the supernatant, concentrate the supernatant unde...

Embodiment 2

[0151] Embodiment 2 A kind of Acanthopanax composition and its preparation method and content determination

[0152] 1. Preparation method:

[0153] (1), pre-treatment: after cleaning and pulverizing 1000g Acanthopanax,

[0154] Add 10 times the volume of purified water to decoct for 3.5 hours, then separate the decoction; add 10 times the volume of purified water to decoct for 3.5 hours, then separate the decoction; add 10 times the volume of purified water to decoct for 3.5 hours, then separate the decoction; Then add 10 times the volume of ice, after cooling to room temperature, decoct for 3.5 hours, and separate the decoction; then add 10 times the volume of ice, after cooling to room temperature, decoct for 3.5 hours, and separate the decoction; Combine the decoctions to obtain Liquid A;

[0155] (2) Calcium sulfur treatment: when the liquid A is cooled to below 28°C, add 20% by weight milk of lime to adjust the pH value to 12.0, let it stand for 20 hours, and then use ...

Embodiment 3

[0161] Embodiment 3 A kind of Acanthopanax composition and its preparation method and content determination

[0162] 1. Preparation method

[0163] (1), pretreatment: After cleaning and crushing 1000g Acanthopanax senticosus, add 8 times the volume of purified water to decoct for 5 hours, then separate the decoction; add 8 times the volume of purified water to decoct for 5 hours, separate the decoction; then Add 8 times the volume of ice, cool to room temperature, decoct for 5 hours, separate the decoction; then add 8 times the volume of ice, cool to room temperature, decoct for 5 hours, separate the decoction; combine decoction to obtain liquid A;

[0164] (2) Lime sulfur treatment: when the liquid A is cooled below 35°C, add 20% milk of lime by weight to adjust the pH value to 10.0, let it stand for 24 hours, and then adjust the pH value to 5.5 with sulfuric acid , after stirring evenly, let it stand for 30 hours, filter the supernatant, concentrate the supernatant under r...

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Abstract

The invention belongs to the field of pharmaceutical preparations, and in particular relates to an Acanthopanax senticosus composition, a preparation containing the same and a detection method thereof. The Acanthopanax senticosus composition contains 31-167mg / g total glycosides, 11-199mg / g total flavonoids, 224-736mg / g total sugars and 20-173mg / g total inorganic salts. The detection method includes detection of (1) total glycosides, (2) total sugars, (3) total flavonoids, (4) total inorganic cations, (5) total inorganic anions, and (6) total solids. The components in the Acanthopanax senticosus composition and injection provided by the invention are more balanced, have obvious effects in lowering blood sugar and blood fat, and have better drug efficacy than the prior art; relatively less toxicity and safer.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to an Acanthopanax senticosus composition, a preparation containing the same and a detection method thereof. Background technique [0002] Eleutherococcus senticosus (Latin scientific name: Eleutherococcus senticosus), aliases: thorn crutches, Kanguai sticks, one hundred needles, tigers, five ginseng, Russian ginseng, Siberian ginseng, deciduous shrubs, mainly distributed in northeastern Asia and Siberia . Its roots and rhizomes can be used as medicine, which has the effects of nourishing qi and invigorating the spleen, nourishing the kidney and calming the nerves, promoting blood circulation and removing blood stasis. "Compendium of Materia Medica" records that Acanthopanax can "replenish strength and essence, improve eyesight and lower qi", and can "replenish five labors and seven Injury, long-term use to lighten the body and endure old age", it is often use...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/254A61P3/06A61P3/10A61P15/00G01N21/31
CPCA61K9/0019A61K9/08A61K36/254A61K2236/331A61K2236/39A61K2236/51A61K2236/53G01N21/31
Inventor 方同华项彦华徐秀杰周广红王维龙王博冯慧董丽丽贾文娟
Owner HARBIN ZHENBAO PHARMA
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