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Acanthopanax senticosus extract composition, extraction method and acanthopanax senticosus injection

A technology of Acanthopanax senticosus extract and Acanthopanax senticosus injection, which is applied in the field of Acanthopanax senticosus extract composition, can solve the problems of cumbersome process, long extraction cycle, and many steps, and achieve less process steps, reduce cerebral edema, The effect of simple operation

Active Publication Date: 2020-12-18
HARBIN ZHENBAO PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is to extract eleutherosides and polysaccharides separately, which has many steps, complicated process and long extraction period.

Method used

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  • Acanthopanax senticosus extract composition, extraction method and acanthopanax senticosus injection
  • Acanthopanax senticosus extract composition, extraction method and acanthopanax senticosus injection
  • Acanthopanax senticosus extract composition, extraction method and acanthopanax senticosus injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation of Acanthopanax extract composition:

[0027] (1) crushing: the roots and stems of Acanthopanax senticosus are crushed to make crushed material;

[0028] (2) Add 5 kg of Acanthopanax senticosus crushed material, add 12 times the amount of water to reflux extract three times, each time for 1 hour, filter, combine the filtrate, and concentrate under reduced pressure at 60 ° C to a concentrated paste with a relative density of 1.10;

[0029] (3) Add ethanol until the alcohol content reaches 85%, let it stand for 12 hours, filter and collect the filtrate, recover the ethanol under reduced pressure, and obtain the alcohol precipitated paste;

[0030] (4) Adjust the pH value of the alcohol precipitation paste to 5.0, and use a macroporous resin column for adsorption. The flow rate of the upper liquid is 2BV / h for adsorption, and the tail liquid is collected, and then eluted with 60% ethanol. The amount of eluent is 2BV. The flow rate is 1.5BV / h, and the eluate is...

Embodiment 2

[0034] Preparation of Acanthopanax extract composition:

[0035] (1) crushing: the roots and stems of Acanthopanax senticosus are crushed to make crushed material;

[0036] (2) Add 5 kg of Acanthopanax senticosus powder into 11 times the amount of water to reflux and extract three times, each time for 1.5 hours, filter, combine the filtrates, and concentrate under reduced pressure at 60 ° C to a concentrated paste with a relative density of 1.10;

[0037] (3) Add ethanol until the alcohol content reaches 85%, let it stand for 12 hours, filter and collect the filtrate, recover the ethanol under reduced pressure, and obtain the alcohol precipitated paste;

[0038] (4) Adjust the pH value of the alcohol precipitation paste to 5.5, and use a macroporous resin column for adsorption, and the flow rate of the upper liquid is 2BV / h for adsorption, and the tail liquid is collected; then, it is eluted with 50% ethanol, and the amount of eluent is 2BV, The flow rate is 1.5BV / h, the elua...

Embodiment 3

[0042] Preparation of Acanthopanax extract composition:

[0043] (1) crushing: the roots and stems of Acanthopanax senticosus are crushed to make crushed material;

[0044] (2) Add 5 kg of Acanthopanax senticosus crushed material to 10 times the amount of water to reflux and extract three times, each time for 2 hours, filter the combined filtrate, and concentrate under reduced pressure at 60 ° C to a concentrated paste with a relative density of 1.10;

[0045] (3) Add ethanol until the alcohol content reaches 85%, let it stand for 12 hours, filter and collect the filtrate, recover the ethanol under reduced pressure, and obtain the alcohol precipitated paste;

[0046] (4) Adjust the pH value of the alcohol precipitation paste to 6.0, and use a macroporous resin column for adsorption, and the flow rate of the upper liquid is 2BV / h for adsorption, and the tail liquid is collected; then, it is eluted with 65% ethanol, and the amount of eluent is 2BV, The flow rate is 1.5BV / h, the...

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Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to an acanthopanax senticosus extract composition and an extraction method thereof, and a preparation method of an acanthopanax senticosus injection. The acanthopanax senticosus extract composition comprises the following components of fructose, glucose, sucrose, maltose, chlorogenic acid, cryptochlorogenic acid, neochlorogenic acid, eleutheroside B and eleutheroside E. The preparation method of the acanthopanax senticosus composition comprises the steps of performing water extraction and alcohol precipitation on acanthopanax senticosus medicinal materials, adsorbing the processed medicinal materials with macroporous adsorption resin and eluting with ethanol with a certain concentration. The acanthopanax senticosus composition is used for treating cardiovascular system diseases.

Description

technical field [0001] The invention relates to an acanthopanax extract, in particular to a composition, an extraction method and a preparation method of the acanthopanax extract. Background technique [0002] Acanthopanax is the dry root, rhizome or stem of Acanthopanax senticosus (Rupr. et Maxim.) Harms, a plant of the family Araliaceae. It is mainly distributed in Heilongjiang, Jilin, Liaoning, Hebei and Shanxi. It is pungent and slightly bitter , warm in nature, returns to the spleen, kidney, heart meridian, has the effect of invigorating qi and invigorating the spleen, tonifying the kidney and calming the nerves. [0003] Modern pharmacological studies have shown that Acanthopanax has the functions of protecting the central nervous system and cardiovascular and cerebrovascular systems, anti-tumor, anti-aging, anti-radiation, and enhancing the body's immunity, especially in the treatment of ischemic stroke. Acanthopanax contains more active ingredients, mainly including...

Claims

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Application Information

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IPC IPC(8): A61K36/254A61K9/08A61K47/02A61P9/10A61P29/00A61K125/00A61K135/00
CPCA61K36/254A61K9/0019A61K9/08A61K47/02A61P9/10A61P29/00A61K2236/15A61K2236/331A61K2236/55
Inventor 方同华闫久江陈玉梅葛一蒙康宁姚洪艳韩冰佟美鸿王博董丽丽赵涛夏迎迎
Owner HARBIN ZHENBAO PHARMA
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