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A kind of compound zinc selenium polypeptide compound and preparation method thereof

A technology for peptide compounds and peptide complexes, which is applied in the field of chemistry and can solve the problems of difficult chemical synthesis, limitations, and low biological activity.

Active Publication Date: 2016-04-13
GUANGZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the chemical synthesis of pure peptides is difficult and costly, and the biological activity of chemically synthesized peptides is often lower than that of peptides prepared from animals and plants, the application of chemically synthesized peptides and trace elements to prepare metal complexes will also be affected. certain limit

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0020] (1) Pretreatment of fish meat: Frozen fish meat is quickly chopped with a meat grinder or chopping machine, and then finely ground with a colloidal grinder. At the same time, the amount of water is added according to the weight ratio of raw materials: water is 1:1.

[0021] (2) Enzymatic hydrolysis: take the above-mentioned ground raw materials, add water according to the weight ratio of total raw materials: water = 1:3, stir evenly, adjust the pH to 8.5 with sodium bicarbonate, and then add 500U / g raw protein The alkaline protease Alcalase2.4LFG was used for enzymolysis in a constant temperature enzymolysis tank at 55°C, with low-speed (15-20r / min) continuous rotation stirring or intermittent stirring once every 10 minutes, and enzymolysis for 4 hours.

[0022] (3) Selenium zinc polypeptide compound preparation:

[0023] 1. adjust the pH of the polypeptide solution obtained in step (2) to 6.5 with acetic acid;

[0024] ②Add zinc acetate or zinc oxide to the polypeptid...

example 2

[0029] (1) Pretreatment of fish meat: Frozen fish meat is quickly chopped with a meat grinder or a chopping machine, and then ground with a colloid mill. During the grinding process, the water is replenished according to the weight ratio of raw materials: water is 1:1.

[0030] (2) Enzymatic hydrolysis: take the above-mentioned ground raw materials, add water according to the weight ratio of total raw materials: water=1:2.5, stir evenly, adjust the pH to 8.5 with sodium bicarbonate, and then use 1000U / g raw protein Add alkaline protease Alcalase2.4LFG, carry out enzymolysis in a constant temperature enzymolysis tank at 55°C, stir continuously at low speed (15-20r / min) or intermittently stir once every 10 minutes, and perform enzymolysis for 3.5h.

[0031] (3) Selenium zinc polypeptide compound preparation:

[0032] 1. adjust the pH of the polypeptide solution obtained in step (2) to 6.5 with acetic acid;

[0033] ②Add zinc acetate or zinc oxide to the polypeptide solution, he...

example 3

[0038] (1) Pretreatment of fish meat: Frozen fish meat is quickly chopped with a meat grinder or a chopping machine, and then ground with a colloid mill. During the grinding process, the water is replenished according to the weight ratio of raw materials: water is 1:1.

[0039] (2) Enzymatic hydrolysis: take the above-mentioned ground raw materials, add water according to the weight ratio of total raw materials: water = 1:2.5, stir evenly, adjust the pH to 8.5 with sodium bicarbonate, and then add 1000U / g raw protein The alkaline protease Alcalase2.4LFG was enzymolyzed in a constant temperature enzymolysis tank at 55°C, with low-speed (15-20r / min) continuous rotation stirring or intermittent stirring once every 10 minutes, and enzymolysis for 3.5h.

[0040] (3) Selenium zinc polypeptide compound preparation:

[0041] ① adjust the pH of the polypeptide solution obtained in step (2) to 6.5 with citric acid;

[0042] ② Add zinc citrate or zinc oxide to the polypeptide solution, ...

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Abstract

The invention provides a compound zinc-selenium polypeptide compound and a preparation method thereof. The compound is obtained by hydrolyzing fish meat and protease under certain conditions to obtain a polypeptide, and then reacted with inorganic zinc and inorganic selenium respectively; the compound not only contains abundant The peptide component also contains important trace elements zinc and selenium, which have multiple functions such as satisfying the body's supplementary polypeptide and supplementing organic selenium and organic zinc.

Description

technical field [0001] The invention relates to the field of chemistry, in particular to a compound trace element polypeptide compound and its preparation. Background technique [0002] Selenium is one of the essential trace elements for living organisms. It has the functions of resisting lipid peroxidation and protecting biological membranes. Selenium deficiency can lead to many diseases such as Keshan disease, diabetes, cardiovascular disease, cataract, tumor, easy aging and so on. Therefore, selenium plays an important role in human anti-cancer, anti-aging, anti-oxidation, prevention and treatment of cardiovascular diseases, Keshan disease and Kaschin-Beck disease. The trace element selenium is closely related to organisms, especially human health. relationship has aroused great interest. The selenium intake in animal feed is 0.1-0.2mg·kg-1, and selenium deficiency will occur if it is lower than 0.05mg·kg-1. Appropriate amount of selenium supplementation is of great s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P21/06A23L33/18
CPCB65D81/3211A45D34/045A45D2200/055B65D51/2807
Inventor 曾庆祝许庆陵
Owner GUANGZHOU UNIVERSITY