Broad spectrum monoclonal antibody for identification of influenza virus hemagglutinin protein HA1 structural domains

A monoclonal antibody, hemagglutinin protein technology, applied in the direction of antiviral immunoglobulins, antibodies, antiviral agents, etc., can solve the problem that the neutralization activity is limited to a few strains of each subtype.
CN104098692AActive Publication Date: 2014-10-15XIAMEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
XIAMEN UNIV
Publication Date
2014-10-15

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Abstract

The invention relates to an antibody for identification of epitopes on influenza virus hemagglutinin protein HA1 structural domains, a cell strain generating the antibody and the use of the antibody and the cell strain. The antibody is can cross the HA subtype for specific binding of the hemagglutinin (HA) protein HA1 structural domains of H1 subtype (including seasonal H1N1 and new H1N1) and H5 subtype influenza virus. Therefore, the invention also relates vaccines or pharmaceutical compositions which comprise the antibody and are used for prevention and / or treatment of H1 subtype and H5 subtype influenza virus infection and / or diseases (such as the flu) induced by the H1 subtype and H5 subtype influenza virus.
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Description

technical field

[0001] The invention relates to the field of molecular virology, especially the field of vaccine prevention of influenza virus. Specifically, the present invention relates to an antibody that recognizes an epitope on the HA1 domain of the hemagglutinin protein of influenza virus, a cell line producing the antibody, and their use. The antibody of the present invention can specifically bind to the HA1 domain of the hemagglutinin (HA) protein of H1 subtype (including seasonal H1N1 and new A H1N1) and H5 subtype influenza virus across HA subtypes. Therefore, the present invention also relates to vaccines or pharmaceutical compositions useful for preventing and / or treating infection of H1 subtype and H5 subtype influenza virus and / or diseases (such as influenza) caused by said infection, which comprise the Antibody. Background technique

[0002] Influenza, referred to as influenza, is a respiratory infectious disease caused by influenza virus. Its clinical chara...

Claims

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