A compound polysaccharide of Morinda officinalis and Rhizoma Polygonatum with the effect of regulating tumor microenvironment and its preparation method and application

A technology of tumor microenvironment and polysaccharide polysaccharide, applied in the field of Morinda officinalis and polysaccharide polysaccharide and preparation thereof, can solve the problems of extraction and the like, and achieve the effects of low cost, good antitumor activity and simple process

Active Publication Date: 2016-10-19
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, no one has used Morinda officinalis and Polygonatum as raw materials to extract polysaccharides and prepare complex polysaccharides, which are used to regulate the tumor microenvironment and assist in the application of anti-tumor health food

Method used

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  • A compound polysaccharide of Morinda officinalis and Rhizoma Polygonatum with the effect of regulating tumor microenvironment and its preparation method and application
  • A compound polysaccharide of Morinda officinalis and Rhizoma Polygonatum with the effect of regulating tumor microenvironment and its preparation method and application
  • A compound polysaccharide of Morinda officinalis and Rhizoma Polygonatum with the effect of regulating tumor microenvironment and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The compound polysaccharides of Morinda officinalis and Rhizoma Polygonatum in this example, its active ingredient is compounded from Radix Morinda officinalis polysaccharide and Rhizoma Polygonatum polysaccharide, wherein the mass ratio of Radix Morinda officinalis polysaccharide and Rhizoma Polygonatum polysaccharide is Morinda officinalis polysaccharide 10, Rhizoma Polygonatum polysaccharide Polysaccharide 100.

[0038] The above-mentioned Morinda officinalis and Polygonatum complex polysaccharides are prepared by the following method:

[0039] (1) Preparation of Morinda officinalis polysaccharide: Select 3kg of Morinda officinalis medicinal material, add 30L of water, heat and boil for extraction, extract 3 times in total, extract for 5 hours each time, combine extracts and concentrate to about 5L to obtain concentrated solution a1, concentrate The solution a1 was dialyzed with a dialysis bag (3500 Da, the same below) and running water for about 2 days to obtain a d...

Embodiment 2

[0043] The compound polysaccharides of Morinda officinalis and Rhizoma Polygonatum in this example, its active ingredient is compounded from Radix Morinda officinalis polysaccharide and Rhizoma Polygonatum polysaccharide, wherein the mass ratio of Radix Morinda officinalis polysaccharide and Rhizoma Polygonatum polysaccharide is Morinda officinalis polysaccharide 200, Rhizoma Polygonatum polysaccharide Polysaccharides8.

[0044] The above-mentioned Morinda officinalis and Polygonatum complex polysaccharides are prepared by the following method:

[0045] (1) Preparation of Morinda officinalis polysaccharide: select 3kg of Morinda officinalis medicinal material, add 60L of water, heat and boil for extraction, extract 3 times in total, extract for 4 hours each time, combine extracts and concentrate to about 5L to obtain concentrated solution a1, concentrate The solution a1 was dialyzed with a dialysis bag and convective water for about 2 days to obtain a dialysate b1, and the dia...

Embodiment 3

[0049] The compound polysaccharides of Morinda officinalis and Polygonatum polysaccharides in this example are compounded from Morinda officinalis polysaccharides and Polygonatum polysaccharides, wherein the mass ratio of Morinda officinalis polysaccharides and Polygonatum polysaccharides is 30% of Morinda officinalis polysaccharides and 80% of Polygonatum polysaccharides.

[0050] The above-mentioned Morinda officinalis and Polygonatum complex polysaccharides are prepared by the following method:

[0051] (1) Preparation of Morinda officinalis polysaccharide: Select 3kg of Morinda officinalis medicinal material, add 30L of water, heat and boil for extraction, extract 3 times in total, extract for 5 hours each time, combine extracts and concentrate to about 5L to obtain concentrated solution a1, concentrate The solution a1 was dialyzed with a dialysis bag and convective water for about 2 days to obtain a dialysate b1, and the dialysate b1 was concentrated to obtain a concentrat...

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Abstract

The invention discloses a complex polysaccharide of Morinda officinalis and Rhizoma Polygonatum with the effect of regulating the tumor microenvironment. Morinda officinalis polysaccharides are 10-250, Polygonatum polysaccharides are 1-50, the compound polysaccharides of Morinda officinalis and Polygonatum have high purity and activity, and have the effect of regulating tumor microenvironment. Also disclosed is a preparation method of the above-mentioned Morinda officinalis and Rhizoma Polygonatum compound polysaccharide, the preparation method has simple, stable and efficient process, is suitable for industrial production, and has low cost. Environmental efficacy of health food applications.

Description

technical field [0001] The invention belongs to the technical field of polysaccharides, and in particular relates to a compound polysaccharide of Morinda Citrifolia and Rhizoma Polygonatum with the effect of regulating tumor microenvironment, its preparation method and application. Background technique [0002] Malignant tumors are currently a serious disease that endangers human health. Chemotherapy is one of the main methods used in the systemic treatment of malignant tumors. However, most anti-tumor chemical drugs also seriously damage normal cells while killing tumor cells. Tumor recurrence and metastasis are universal problems that plague clinical tumor treatment. The reason is that the targets of existing treatments are still focused on the tumor cells themselves, while ignoring the importance of their microenvironment. The relationship between the tumor microenvironment and tumor cells is the relationship between soil and seeds. The process of tumor malignant transfor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L5/00C08B37/00A23L29/30A23L33/125
Inventor 胡明华马方励王培培梁明
Owner INFINITUS (CHINA) CO LTD
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