The application of clarithroside e as preparation of medicine for treating arrhythmia

Abstract

The present invention relates to the application method of the valve-shaped box-like glucoside E in the preparation of medicine for treating arrhythmia. The medicament for treating arrhythmia is prepared by applying clavetrin E, the excipients and the preparation method can be in any pharmaceutically acceptable form, the dose can be changed according to factors such as the way of administration, the age of the patient, the severity of the condition, and the oral dose for adults is 1 -200mg / day, the adult injection dose is 1-50mg / day, the prepared drug can obviously resist the arrhythmia induced by chloroform in mice, adrenaline-induced rabbits, barium chloride-induced rats, and aconitine-induced rats. significantly.

Description

technical field [0001] The present invention relates to the application method of clavetrin E, especially the application method in the preparation of drugs for treating arrhythmia. Background technique [0002] Lobatoside E, a natural compound, its molecular formula: C 65 h 102 o 31 , molecular weight: 1379.5. Boxgrass glycoside E is one of the active ingredients in Boxella petalifera, CAS accession number: 123714-91-0. [0003] Modern studies have shown that boxyrin E has cytotoxic activity. The half-inhibitory concentrations GI50 of A-549, SK-MEL5 and SW620 cell lines were 0.14μM, 0.14μM and 0.36μM respectively. [0004] The traditional Chinese medicine box grass, also known as zygote grass, Tianqiu grass, white grass, etc., is the whole grass, seeds and leaves of the Cucurbitaceae plant Box grass (Actinostemmatenerum Griff), distributed in North and South my country, Korea, Japan, the Soviet Union, India, Indochina Peninsula There are also distributions. Zygonia is...

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Problems solved by technology

[0009] In the prior art, there is no disclosure of the application of clarithroside E as a drug for the preparation of arrhythmia

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