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The Extraction Method and Application of the Active Components of Radix Ginseng

A technology of active components and extraction methods, applied to anti-inflammatory drugs, can solve problems such as no anti-cancer, anti-inflammatory, and antibacterial effects, and achieve obvious social and economic benefits, less side effects, and expanded application effects.

Inactive Publication Date: 2017-08-11
李玉英 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But so far, in the study of Xianghe extract, there are no reports on its anti-cancer, anti-inflammatory, and antibacterial effects

Method used

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  • The Extraction Method and Application of the Active Components of Radix Ginseng
  • The Extraction Method and Application of the Active Components of Radix Ginseng
  • The Extraction Method and Application of the Active Components of Radix Ginseng

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Extraction of active components

[0020] 1. Raw materials and materials:

[0021] The rhizomes of the lotus are collected from Mogan Mountain in Huzhou, Zhejiang.

[0022] 2. Reagents:

[0023] Ultrapure water is produced by Millipore Water Purifier.

[0024] 3. Instrument and equipment:

[0025] The rotary evaporator was purchased from Shanghai Yarong Biochemical Instrument Factory.

[0026] 4. The extraction method includes the following steps:

[0027] (1) Take the dried rhizome of Z. chinensis as raw material, cut into 0.5-1cm sections, add ultrapure water and soak for 12-24 hours. The amount of ultrapure water added is 8 times the mass of Z. chinensis, then proceed. Decoction, time is 1 hour, filter after decoction;

[0028] (2) Take the filter residue obtained by filtration, add 8 times the mass of ultrapure water of the filter residue, decoct for 1 hour, filter after the decoction, and repeat the above steps;

[0029] (3) Combine the filtrate obtained by filtering i...

Embodiment 2

[0030] Example 2: Anti-tumor pharmacological experiment

[0031] 1. Experimental materials

[0032] 1.1 Animals

[0033] SPF-grade Kunming mice (KM mice), ♂, weight 18-22g, purchased from Changsheng Biotechnology Co., Ltd. by Experimental Animal Center of Shenyang Pharmaceutical University. Animals are raised in SPF-level laminar flow racks, free to eat and drink, the ambient temperature is 23±2°C, the humidity is 30%-70%, and the lighting time is 12h / d (lights on from 7:00 to 19:00). The experiment was carried out after breeding for 3 days.

[0034] 1.2 Medicines and reagents

[0035] Cyclophosphamide for injection was purchased from Jiangsu Hengrui Pharmaceutical Co., Ltd., batch number 12060625. S180 and H22 tumor strains were provided by the Department of Pharmacology of Shenyang Pharmaceutical University.

[0036] 2. Experimental method

[0037] 2.1 The anti-tumor effect of the water extract of Zhanhe on S180 tumor-bearing mice

[0038] Select S180 tumor-derived mice with good heal...

Embodiment 3

[0056] Example 3: Analgesic and anti-inflammatory experiments

[0057] 1. Experimental materials

[0058] 1.1 Animals

[0059] SPF-grade Kunming mice (KM mice), ♂, weight 18-22g, purchased from Changsheng Biotechnology Co., Ltd. by Experimental Animal Center of Shenyang Pharmaceutical University. Animals are raised in SPF-level laminar flow racks, free to eat and drink, the ambient temperature is 23±2°C, the humidity is 30%-70%, and the lighting time is 12h / d (lights on from 7:00 to 19:00). The experiment was carried out after breeding for 3 days.

[0060] 1.2 Medicines and reagents

[0061] Aspirin was purchased from Shenyang Aohua Pharmaceutical Co., Ltd., batch number 121101; xylene was purchased from Tianjin Dibo Chemical Co., Ltd., batch number 20090224; glacial acetic acid was purchased from Tianjin Damao Chemical Reagent Factory, batch number 20111118.

[0062] 2. Experimental method

[0063] 2.1 Writhing reaction experiment in mice

[0064] Fifty female KM mice, weighing 18-22 g,...

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Abstract

The invention provides a method for extracting active ingredients from mioga ginger. The method comprises the following steps: by taking dried mioga ginger rhizome as a raw material, cutting the mioga ginger rhizome into sections of 0.5-1cm, adding 8 times of ultrapure water for soaking for 12-24 hours, decocting for an hour, and filtering after decocting is ended; taking the filtered filter residue, adding the ultrapure water which is 8 times that of the mass of the filter residue, decocting for an hour, filtering and repeating the previous steps; and merging all the filtered filtrate, concentrating and drying the filtrate into a solid state. The obtained target active ingredients can be applied to preparing antitumor drugs, anti-inflammatory and analgesic medicines and antibacterial agents.

Description

Technical field [0001] The present invention relates to the technical field of traditional Chinese medicine product processing, in particular to a method for extracting active components from Zhanhe, and the use of the extracted active components in the preparation of anti-tumor drugs, analgesic, anti-inflammatory drugs, and antibacterial drugs application. Background technique [0002] Zingiber mioga (Zingiber mioga), a ginger genus of the ginger family, is a perennial herb, commonly known as wild ginger, minghe, and impotence. The tender buds, flower shafts and tender stems are fragrant and slightly sweet. They can be served cold or fried, and can also be used to make pickles. They are rare vegetables with high nutritional value. The tender stems of Hanhei have a special smell. In addition to the volatile components with special smells, many medicinal components have been identified in the volatile oil, such as alkanols, ketones, aldehydes, epoxy compounds and ethers, borneol,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A23L33/00A61P29/00A61P35/00A61P31/04A61P31/10
Inventor 李玉英魏秀岩魏秀杰
Owner 李玉英
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