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Artemisinin preparation method

A technology of artemisinin and Artemisia annua, applied in the production of bulk chemicals, organic chemistry, etc., can solve the problems of reduced contact time of the extract, increased flow rate of the extractor, and shortened residence time, achieving excellent mass transfer effect and manufacturing Effects of cost reduction and short extraction time

Inactive Publication Date: 2014-11-12
TIANJIN V SENT MEDICINE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CO 2 If the flow rate is too large, it will cause CO in the extractor 2 As the flow rate increases, the CO 2 The residence time is shortened, and the contact time with the extracted substance is reduced, which is not conducive to the improvement of the extraction rate

Method used

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  • Artemisinin preparation method

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Embodiment 1

[0029] A preparation method of artemisinin, using supercritical CO2 high pressure liquid as extraction liquid, through the mixing process of isothermal method and isobaric method, using the separation means of pressurized countercurrent and reduced pressure evaporation, from Artemisia annua L. ), the novel sesquiterpene lactone containing peroxy bridge was isolated, and the specific steps are as follows:

[0030] (1) Naturally sun-dried the whole plant of Artemisia annua, crushed, sieved, 60 mesh;

[0031] (2) Artemisia annua is crushed and sieved into the extraction kettle of the HA121O50O01 type supercritical extraction device extractor with a volume of 1L. 2 CO from storage tank 2 It is cooled into a liquid state, compressed by a high-pressure pump, and then enters the extractor through a preheater, where it contacts and transfers mass with the raw material Artemisia annua, and dissolves the solute in supercritical CO. 2 After two-stage heating and two-stage decompression...

Embodiment 2

[0037] A preparation method of artemisinin, using supercritical CO2 high-pressure liquid as the extraction liquid, through the mixing process of isothermal method and isobaric method, and adopting the separation means of pressurized countercurrent and reduced pressure evaporation, from Artemisia annua L. ) to isolate novel sesquiterpene lactones containing peroxo bridges, the specific steps are as follows:

[0038] (1) Naturally dry the whole Artemisia annua herb, crush it, and sieve it to 40 meshes;

[0039] (2) Artemisia annua is crushed and sieved and put into the extraction kettle of the HA121O50O01 type supercritical extraction device extractor with a volume of 1L. 2 CO from storage tank 2 Cooled into a liquid state, then compressed by a high-pressure pump, enters the extractor through a preheater, contacts and mass transfers with the raw material Artemisia annua, and the supercritical CO dissolved in the solute 2 After two-stage heating and two-stage decompression, it ...

Embodiment 3

[0041] A preparation method of artemisinin, using supercritical CO2 high-pressure liquid as the extraction liquid, through the mixing process of isothermal method and isobaric method, and adopting the separation means of pressurized countercurrent and reduced pressure evaporation, from Artemisia annua L. ) to isolate novel sesquiterpene lactones containing peroxo bridges, the specific steps are as follows:

[0042] (1) Naturally dry the whole Artemisia annua herb, crush it, and sieve it to 80 mesh;

[0043] (2) Artemisia annua is crushed and sieved and put into the extraction kettle of the HA121O50O01 type supercritical extraction device extractor with a volume of 1L. 2 CO from storage tank 2 Cooled into a liquid state, then compressed by a high-pressure pump, enters the extractor through a preheater, contacts and mass transfers with the raw material Artemisia annua, and the supercritical CO dissolved in the solute 2 After two-stage heating and two-stage decompression, it en...

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Abstract

The invention relates to an artemisinin preparation method. Novel sesquiterpene lactone containing a peroxide bridge is separated from sweet wormwood herb by adopting pressurizing countercurrent and reduced pressure evaporation separating means through an isothermal technology and an isobaric technology with a supercritical CO2 high pressure liquid as an extracting liquid. The artemisinin preparation method adopting the supercritical extraction technology and SC-CO2 extraction is an environmentally friendly method, and the above supercritical fluid has a same extraction capability with a liquid solvent, and also has an excellent mass transfer effect, so the use of a large amount of an organic solvent is avoided, and the harmfulness to the health of human bodies and the pollution to the environment in the extraction process are prevented. The artemisinin preparation method has the advantages of short extraction time, high extraction rate, energy saving, production cost saving and the like, and is suitable for large-scale industrial production.

Description

technical field [0001] The invention relates to the field of artemisinin production, in particular to a preparation method of artemisinin. Background technique [0002] Malaria is one of the serious diseases that threaten human life, especially in tropical and subtropical regions. "Malaria kills, on average, a child under the age of 5 every 30 seconds, and malaria is also one of the main causes of chronic economic distress in Africa." , have developed resistance. [0003] Artemisia annua is the dry aerial part of Artemisia annua, and artemisinin is a colorless crystal extracted and isolated from Artemisia annua. The new antimalarial active ingredient compound is the hottest antimalarial drug after chloroquine, pyrimethamine and primiquine. "Artemisinin-based combination therapy" can be effective in 3 days, which is 4 days shorter than traditional chloroquine therapy. At present, WHO has listed artemisinin-based combination therapy as the preferred method for the treatmen...

Claims

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Application Information

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IPC IPC(8): C07D493/20
CPCC07D493/20Y02P20/54
Inventor 兰赫
Owner TIANJIN V SENT MEDICINE TECH
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