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Traditional Chinese medicine preparation, preparation method and application of traditional Chinese medicine preparation

A technology for traditional Chinese medicine preparations and pharmaceutical excipients, which is applied in pharmaceutical formulations, drug combinations, and medical preparations containing active ingredients, etc., can solve the problems of unclear process conditions, low extraction rate of active ingredients, etc. The effect of retaining active ingredients and high extraction rate

Active Publication Date: 2014-11-19
肇庆星湖制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the flavonoids are thermally unstable compounds. The existing extraction process is produced by the boiling method adopted by folk prescriptions. The range of process conditions is not clear, and the extraction rate of the active ingredients of Rhododendron viburnum is low

Method used

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  • Traditional Chinese medicine preparation, preparation method and application of traditional Chinese medicine preparation
  • Traditional Chinese medicine preparation, preparation method and application of traditional Chinese medicine preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1: prepare extract or thick paste 1

[0043] Add Rhododendron azalea crushed to 30 meshes into 55wt% ethanol aqueous solution and soak for 4 hours, and then add it to a percolation device for percolation. The flow rate of the percolation liquid is 1L / h, and the obtained percolation liquid is collected; the Rhododendron azalea in the percolation device is taken out, and 60wt% ethanol aqueous solution of 3 times the weight of Rhododendron azalea before percolation is added, and the percolation is carried out at a temperature lower than 80°C. Under high temperature, extract twice under vacuum and decompression, each time for 15 minutes, collect the extracts extracted twice; combine the percolation liquid and the extracts, recover ethanol under reduced pressure, concentrate into a thick paste or dry after concentration Into an extract 1.

[0044] The flavone content in the percolation solution and the extraction solution was combined and recorded in Table 1.

Embodiment 2

[0045] Embodiment 2: prepare medicinal extract or thick paste 2

[0046] Add Rhododendron azalea crushed to 18 meshes into 50wt% ethanol aqueous solution and soak for 8 hours, then add it into a percolation device for percolation. The flow rate of the percolation liquid is 2L / h, and the obtained percolation liquid is collected; the Rhododendron azalea in the percolation device is taken out, and 50wt% ethanol aqueous solution of 5 times the weight of Rhododendron azalea before percolation is added, and the percolation is carried out at a temperature lower than 80°C. Under high temperature, extract twice under vacuum and reduced pressure, each time for 30 minutes, and collect the extracts extracted twice; combine the percolation liquid and the extracts, recover ethanol under reduced pressure, concentrate into a thick paste or dry after concentration into an extract 2.

[0047] The flavone content in the percolation solution and the extraction solution was combined and recorded ...

Embodiment 3

[0048] Embodiment 3: prepare medicinal extract or thick paste 3

[0049] After adding Rhododendron azalea in 70wt% ethanol aqueous solution and soaking for 6 hours, add it into a percolation device for percolation. The flow rate is 1.5L / h, and the obtained percolate is collected; the Rhododendron azalea in the percolation device is taken out, and 70wt% ethanol aqueous solution of 5 times the weight of Rhododendron azalea before percolation is added, and at a temperature lower than 80°C, Vacuum and decompression extraction twice, each extraction 25 minutes, collect the extracts extracted twice; combine the percolation liquid and the extracts, recover ethanol under reduced pressure, concentrate into a thick paste or concentrate and dry into an extract 3.

[0050] The flavone content in the percolation solution and the extraction solution was combined and recorded in Table 1.

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Abstract

The invention discloses a traditional Chinese medicine preparation, a preparation method and application of the traditional Chinese medicine preparation. The preparation method of the traditional Chinese medicine preparation disclosed by the invention comprises the following steps of adding rhododendron mariae into ethanol water to be immersed for 4-8 h, percolating in a percolation device, and collecting percolate, wherein the weight of ethanol water added in the percolating process is 3-5 times of that of rhododendron mariae, and the flow speed of percolate is 1-2 L / h; taking out rhododendron mariae in the percolation device, adding ethanol water, decompressing and extracting in vacuum twice, each time for 15-30 min, and collecting extract solution extracted twice, decompressing and recycling ethanol after mixing percolate with extract solution, concentrating to form thick paste or drying in vacuum to form extract; and adding pharmaceutical auxiliaries into the prepared thick paste or extract, thereby obtaining the traditional Chinese medicine preparation. The invention further provides the traditional Chinese medicine preparation prepared by using the method and application of the traditional Chinese medicine preparation in the fields of drugs having the effects of relieving cough, eliminating phlegm and treating trachitis and acute / chronic bronchitis.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a traditional Chinese medicine preparation with stable quality, a preparation method and application thereof. Background technique [0002] Rhododendron azalea is a plant of Rhododendronaceae. The traditional Chinese medicine preparation made from Rhododendron azalea has antitussive and expectorant effects, and can be used to treat bronchitis, acute and chronic bronchitis. [0003] The active ingredients of Rhododendron azalea are mainly flavonoids, including quercetin and Rhododendron azalea A, B, C, and D five flavonoids. Most of the flavonoids are heat-unstable compounds. The existing extraction process is produced by the boiling method adopted by folk prescriptions. The range of process conditions is not clear, and the extraction rate of the active ingredients of Rhododendron viburnum is low. Contents of the invention [0004] In summary, it is necessary for th...

Claims

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Application Information

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IPC IPC(8): A61K36/45A61P11/14A61P11/10A61P11/00
Inventor 李红兵罗卡
Owner 肇庆星湖制药有限公司
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