Preparation method of instant-dissolving type effervescent salt tablet

An instant, effervescent technology, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve problems such as inappropriateness, foot soaking effect and feeling discount, slow dissolution rate, etc., to achieve comprehensive effect improvement , The dissolution speed is fast, and the effect of accelerating the dissolution

Inactive Publication Date: 2014-12-10
河南省盐业总公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, ordinary salt dissolves slowly in water. Usually, about 7.5g of salt is completely dissolved in 100mL of 50°C water without stirring, and it takes 30min or more
This brings a lot of inconvenience to the use of salt prod

Method used

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  • Preparation method of instant-dissolving type effervescent salt tablet

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0034] Example 1:

[0035] The preparation method of instant effervescent salt tablet of the present invention, the detailed steps of the preparation method are as follows:

[0036] a. Using sodium chloride as the basic raw material, citric acid as the acid source, sodium bicarbonate as the alkali source, 10% polyvinylpyrrolidone-ethanol solution as the binder, polyethylene glycol 4000 as the lubricant, and lactose and The mixture of polyvinylpyrrolidone and PVP (the weight mixing ratio between the two is 1:1); the basic raw material sodium chloride is food grade, and its mass percentage is ≥91%; the sodium chloride is used before use The pulverizer pulverizes and passes through a 60-mesh sieve after pulverization to obtain sodium chloride powder;

[0037] Expressed in parts by weight, the raw material composition of the instant effervescent salt tablet is: 35 parts of sodium chloride powder, 1.0 part of 10% polyvinylpyrrolidone-ethanol solution, 1 part of a mixture of lactose and p...

Example Embodiment

[0044] Embodiment 2: It is basically the same as Embodiment 1, except that:

[0045] In step a: using sodium chloride particles (with a particle size of 0.1 to 3.5 mm) as the basic raw material, using malic acid as the acid source, sodium carbonate as the alkali source, and polyethylene glycol 6000 as the lubricant;

[0046] Expressed in parts by weight, the raw material composition of the instant effervescent salt tablet is: 35 parts of sodium chloride particles, 1.5 parts of 10% polyvinylpyrrolidone-ethanol solution, 0.2 parts of a mixture of lactose and polyvinylpyrrolidone PVP, apple 7 parts of acid, 7 parts of sodium carbonate and 1 part of polyethylene glycol 6000;

[0047] In step b: the mixture of part of lactose and polyvinylpyrrolidone PVP is 45% of the total mixture weight;

[0048] In step c: the drying temperature is 50°C, and the drying time is 80 min;

[0049] In step d: the drying temperature is 50°C, and the drying time is 80min;

[0050] In step e: the pressure during ...

Example Embodiment

[0051] Embodiment 3: It is basically the same as Embodiment 1, except that:

[0052] In step a: using sodium chloride particles (with a particle size of 0.1 to 3.5 mm) as the basic raw material, using tartaric acid as the acid source, potassium bicarbonate as the alkali source, and polyethylene glycol 4000 as the lubricant;

[0053] Expressed in parts by weight, the raw material composition of the instant effervescent salt tablet is: 40 parts of sodium chloride particles, 1.5 parts of 10% polyvinylpyrrolidone-ethanol solution, 0.8 parts of a mixture of lactose and polyvinylpyrrolidone PVP, tartaric acid 8 parts, 8 parts potassium bicarbonate and 1.5 parts polyethylene glycol 4000;

[0054] In step b: the mixture of part of lactose and polyvinylpyrrolidone PVP is 30% of the total mixture weight;

[0055] In step c: the drying temperature is 45°C, and the time is 90 minutes;

[0056] In step d: the drying temperature is 45°C, and the time is 90 minutes;

[0057] In step e: the pressure du...

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Abstract

The invention discloses a preparation method of an instant-dissolving type effervescent salt tablet. The instant-dissolving type effervescent salt tablet is composed of sodium chloride, an adhesive, auxiliaries, an acid source, an alkali source and a lubricant. The preparation method comprises the following steps: putting the sodium chloride into a stirrer, adding the acid source and a proper amount of auxiliaries and lubricant and evenly stirring; then adding the adhesive, evenly stirring and feeding the materials into a kneader for kneading, crushing and drying so as to obtain a mixed material; pouring the alkali source into a mortar, adding the rest of auxiliaries, evenly mixing the alkali source with the auxiliaries and then stopping grinding, and drying and screening the obtained material so as to obtain a mixed material; evenly mixing the two mixed materials in a mixer, tableting, trimming the tablets and screening the tablets after the even mixing; and finally, packaging. The instant-dissolving type effervescent salt tablet can be rapidly dissolved in water, i.e., about 7.5g of salt can be completely dissolved in 100mL of water at 50 DEG C only within 1 minute under the condition that the stirring is not carried out, so that the application efficiency of the effervescent salt tablet is improved.

Description

technical field [0001] The invention relates to a preparation method of salt tablets, in particular to a preparation method of instant effervescent salt tablets. Background technique [0002] Since ancient times, salt has been used as a representative product of cleanliness, whether it is used as a kind of offering to the gods, or it is used to sprinkle the four corners of the venue before the start of sumo, and it is sprinkled on the shoulders after returning from a funeral. It can be proved that "salt" has a cleansing effect. [0003] In addition, there are examples of the use of salt as medicine: in the past, salt water was drunk when the throat was sore or ulcerated, and we recommend that people with respiratory diseases go to the seaside to recuperate, because the patient can breathe the fine salt particles mixed with sea water and evaporate for a long time, These are all familiar methods. At the same time, in many countries, people have become accustomed to using dee...

Claims

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Application Information

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IPC IPC(8): A61K8/20A61K8/36A61K8/86A61K8/02A61Q19/10A61Q19/02A61K33/14A61K9/46
Inventor 左仁杰何占航杨李富左梦巧何若峥
Owner 河南省盐业总公司
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