Production method of calamine lotion

A technology of calamine lotion and a production method, which are applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the difficulty of controlling the limit of microorganisms, and the suspension stability of the calamine lotion. problems such as poor performance, to achieve good suspension stability, ensure bacteriostatic effect, and reduce the risk of use

Active Publication Date: 2014-12-10
HUNAN ER KANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The object of the present invention is to solve the problems of poor suspension stability of calamine lotion and difficult microbial limit control

Method used

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  • Production method of calamine lotion
  • Production method of calamine lotion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] prescription:

[0031] Calamine very fine powder 50g;

[0032] Zinc oxide ultrafine powder 15g;

[0033] Medicinal glycerin 50g.

[0034] Put 50g of calamine ultra-fine powder and 15g of zinc oxide ultra-fine powder into the mortar, add appropriate amount of sterilized water to moisten, grind, pay attention to replenish water during the process, keep the powder moist, after the grinding becomes viscous, add Rinse with sterile water and filter. Then add 50g of medicinal glycerin, stir and mix to form a viscous shape, add appropriate amount of sterilized water and stir at high speed for 30min to prepare a suspension with a mass concentration of 20%, which is the finished product.

Embodiment 2

[0036] prescription:

[0037] Calamine very fine powder 50g;

[0038] Zinc oxide ultrafine powder 150g;

[0039] Medicinal glycerin 50g.

[0040] Put 50g of calamine ultra-fine powder and 150g of zinc oxide ultra-fine powder into the mortar, add appropriate amount of sterilized water to moisten, and grind. Pay attention to replenish water during the process to keep the powder moist. After the grinding becomes viscous, add Rinse with sterile water and filter. Then add 50g of medicinal glycerin, stir and mix to form a viscous shape, add appropriate amount of sterilized water and stir at high speed for 30 minutes to prepare a suspension with a mass concentration of 25%, which is the finished product.

Embodiment 3

[0042] prescription:

[0043] Calamine very fine powder 50g;

[0044] Zinc oxide ultrafine powder 100g;

[0045] Medicinal glycerin 50g.

[0046] Put 50g of calamine ultra-fine powder and 100g of zinc oxide ultra-fine powder into the mortar, add appropriate amount of sterilized water to moisten, grind, pay attention to replenish water during the process, keep the powder moist, after the grinding becomes viscous, add Rinse with sterile water and filter. Then add 50g of medicinal glycerin, stir and mix to form a viscous shape, add appropriate amount of sterilized water and stir at high speed for 30 minutes to prepare a suspension with a mass concentration of 25%, which is the finished product.

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PUM

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Abstract

The invention discloses a production method of a calamine lotion. The method comprises the steps of grinding calamine superfine powder and zinc oxide superfine through a wet method and mixing at a mass ratio of 1: (0.3-3), cleaning, preparing liquid, stirring and filling to obtain a finished product. Through the scheme disclosed by the invention, the finished product has advantages that the stability of suspension liquid is good and microorganisms are effectively controlled.

Description

technical field [0001] The invention relates to a production method of calamine lotion, in particular to a method for preparing calamine lotion by using calamine powder and zinc oxide through wet grinding and mixing, and belongs to the field of pharmaceutical manufacturing. Background technique [0002] Calamine lotion is a commonly used external medicine with a long clinical application time. It has the effect of astringent and skin protection, and is suitable for acute pruritus skin diseases such as urticaria and prickly heat. [0003] There are many preparation methods of calamine lotion, the most common is to add 50g of calamine, 150g of zinc oxide and 50ml of glycerin, add an appropriate amount of water, grind, add water to make 1000ml, mix well, and get ready. But the calamine lotion obtained by this traditional preparation method has the defects of poor suspension performance and poor stability. [0004] Chinese patent CN 1157183 C provides a solution to the stabilit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/30A61K47/36A61K47/34A61K47/26
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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