Application of oleanane triterpene ester derivative in preparation for anti-neurodegeneration medicine
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
An oleanane-type, neurodegenerative technique used in medicine
Active Publication Date: 2014-12-24
ZHEJIANG UNIV
View PDF2 Cites 2 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
So far, there have been no reports of
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0029] compound I-1a and I-1b The preparation method:
[0030]
[0031] Dissolve the compound in 2 ml dichloromethane and 2 ml pyridine in a 25 ml eggplant-shaped bottle ( 1 )[3 , 23,28-trihydroxy-12-oleanene-3 - Caffeate (3 ,23,28-trihydroxy-12-oleanene-3 -caffeate)] (10 mg), add 0.5 mg DMAP (4-dimethylaminopyridine), stir, add 100 μl acetic anhydride, spin dry the reaction solution, perform solvent distribution with water and ethyl acetate, recover the ester layer, and use PTLC And HPLC purification ester layer sample, obtain compound I-1a and I-1b .
[0032] compound I-1a Physical and chemical properties: white solid, high resolution mass spectrum shows that its molecular formula is C 47 h 64 o 10 (HR ESI-TOF-MS m / z (M+Na) + Calcd. for C 47 h 64 o 10 Na: 811.4392, Found: 811.4422); 1 H NMR (500 MHz, CDCl 3 ) 7.57 (d, J= 16.0 Hz, 1H), 7.39 (dd, J = 1.88, 8.34 Hz, 1H), 7.35 (d, J = 1.8 Hz, 1H), 7.21 (d, J = 8.4 Hz, 1H), 6.34 (d, J ...
Embodiment 2
[0049] In animal models of neurodegenerative diseases, studies have found that NGF can prevent or reduce the degeneration of neurons, prevent the progression of AD to a certain extent, and have the effects of promoting nerve growth and neuroprotection. Because PC12 cells have the general characteristics of nerve cells, PC12 cells will stop dividing under the action of NGF, grow protrusions, and transform into neuron-like cells. Therefore, using PC 12 cells as an effective activity identification system to screen active active ingredients will become an effective drug for the treatment of senile dementia.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention provides an application of an oleanane pentacyclic triterpene ester derivative in preparation for medicine for treating senile dementia, and the senile dementia comprises neurodegenerative disease. The medicine is prepared by the oleanane pentacyclic triterpene ester derivative and a pharmaceutically acceptable carrier or an excipient. The oleanane pentacyclic triterpene ester derivative has obvious activity analogous with a nerve growth factor, and can be used for preparing the neurodegenerative disease medicine for treating senile dementia. According to the invention, a structural formula of the oleanane pentacyclic triterpene ester derivative is shown as follows.
Description
technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to oleanane-type pentacyclic triterpene ester derivatives and their application in the prevention and treatment of neurodegenerative diseases such as senile dementia. Background technique [0002] The rapid growth of the elderly population makes people pay more attention to the health status of this group, and Alzheimer's disease seriously affects the health of the elderly, and it has become one of the four main causes of death in adults. In the 2009 report of the International Alzheimer's Association, it was pointed out that in 2010, about 36 million people in the world suffered from dementia, and it will double every 20 years, reaching 66 million in 2030. In 2050, it will reach 115.4 million people, and the number of patients in low- and middle-income countries will account for 71% of the global total. In the 2010 report, the total social cost of Alzheimer's disease ...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more