Caffeoyl-substituted pentacyclic triterpene derivatives and uses thereof

A pentacyclic triterpenoid and caffeoyl technology, applied in the field of medicine, can solve the problems of not showing expected effects, weak clinical efficacy results of neuroprotective agents, and clinical application of large toxic and side effects.
CN103342729BInactive Publication Date: 2016-09-14SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
Publication Date
2016-09-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

Provided are a caffeoyl substituted pentacyclic triterpene derivative as represented by formula (I) and pharmaceutical composition containing the same. Also provided are uses of the derivative in the preparation of drugs or health-care products for preventing and treating brain injury induced by cerebral ischemia, glucose deprivation, and cerebral anoxia, and / or nervous dysfunction, and / or cognitive dysfunction.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a class of caffeoyl-substituted pentacyclic triterpene derivatives and their use in the preparation and prevention and treatment of brain damage and / or neurological dysfunction induced by cerebral ischemia, glucose deficiency and hypoxia. And / or use in medicine or health products for cognitive dysfunction. Background technique

[0002] Advances in Drugs for Cerebral Ischemia Injury

[0003] Acute ischemic stroke belongs to a class of sudden cerebral blood circulation disorders, which extensively affects the transduction of cell signals in the brain, and then induces a large number of neurons in the brain to die, and finally causes severe neurological damage. Based on the pathological characteristics of the disease, it is of great significance to find drugs with neuroprotective effects. Such drugs protect neurons by inhibiting the cascade of pathological reactions in...

Claims

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