Traditional Chinese medicine composition for treating non-small cell lung cancer with matching of TP scheme and preparation process of traditional Chinese medicine composition

A technology for non-small cell lung cancer and a preparation process, which is applied in the field of traditional Chinese medicine compositions for treating middle-advanced non-small cell lung cancer with TP regimen and the preparation process thereof, and can solve problems such as no standardized treatment yet.

Inactive Publication Date: 2015-01-07
李澍
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0002] At present, the treatment of advanced non-small cell lung cancer is still a palliative treatment, which is in the research stage, and there is no standardized treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: The formula is as follows according to weight percentage: phoenix leaves 11%, Astragalus 45%, Radix Ophiopogon japonicus 7.6%, Nansha ginseng 7.6%, Banzhilian 5.6%, Dilong 4.5%, Chuanxiong 4.5%, Guiwei 3.8% , red peony 3.8%, peach kernel 2.3%, safflower 2.3%, centipede 2%. Cut banana leaves and astragalus into 5mm thick slices, add six times the amount of 65% ethanol, reflux extraction for 1 hour, filter the extract, recover ethanol from the filtrate under reduced pressure to make paste-A, after alcohol extraction, banana leaves and Astragalus, decocted with Ophiopogon japonicus and Nansha ginseng twice, 1 hour each time, filtered the decoction, concentrated the filtrate into paste-B with a relative density of 1.22 (80°C), crushed Rhizoma Chuanxiong and Dangguiwei into coarse powder, and mixed well , impregnated with 70% ethanol for 48 hours, then slowly percolated, collected four times the percolation liquid of the crude drug, and recovered the ethanol un...

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PUM

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Abstract

The invention relates to a traditional Chinese medicine composition for treating non-small cell lung cancer with matching of a TP scheme and a preparation process of the traditional Chinese medicine composition, belonging to the field of traditional Chinese medicines. A preparation method comprises the following steps: extracting sago leaf and astragalus by 60-80 percent ethanol, and concentrating the extract to obtain a paste-A; extracting the sago leaf and the astragalus after alcohol extraction with liriope and adenophora tetraphylla by water twice, and concentrating the extract to obtain a paste-B; crushing szechuan lovage rhizome and radix angelicae sinensis into crush powder, percolating by 50-90 percent ethanol, and concentrating the percolating liquid to obtain a paste-C; decocting sculellaria barbata, lumbricus, red peony root, peach kernel, safflower and centipede by water twice, concentrating the filtrate to form a paste with the relative density of 1.08-1.18 (80 DEG C), adding ethanol to enable the alcohol content to be 50-80 percent, uniformly stirring, standing for 48h, taking supernatant, recovering ethanol to obtain a paste-D, combining the paste-A, the paste-B, the paste-C and the paste-D, adding refine honey and potassium sorbate, and uniformly stirring to obtain the traditional Chinese medicine composition. According to the traditional Chinese medicine composition disclosed by the invention, various medicines are used in a matching way, so that the effect of treating the non-small cell lung cancer with matching of the TP scheme is improved, the chemotherapy toxic and side effects are alleviated, and five-year survival rate is increased.

Description

technical field [0001] The composition of the invention relates to a traditional Chinese medicine composition for treating middle and advanced non-small cell lung cancer in combination with TP regimen and a preparation process thereof. Background technique [0002] At present, the treatment of advanced non-small cell lung cancer is still a palliative treatment, which is in the research stage and there is no standardized treatment. In recent years, the application of PTX (taxol) in the treatment of lung cancer, especially advanced non-small cell lung cancer, has shown its good clinical application value. M.D.Anderson Cancer Hospital in the United States reported that the effective rate of PTX (200 mg / m2) monotherapy in 25 cases of newly treated advanced non-small cell lung cancer was 24%. Reference: Erringer Ds. Overview of paclitaxel (Taxol) in advanced lung cancer[J]. Semin Oncol, 1993, 20(4): 46-49. The Standards for Diagnosis and Treatment of Lung Cancer (2011 edition)...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P35/00A61K35/56A61K35/64
CPCA61K35/62A61K35/648A61K36/13A61K36/232A61K36/236A61K36/286A61K36/342A61K36/481A61K36/539A61K36/65A61K36/71A61K36/736A61K36/8968A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 李澍
Owner 李澍
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