Suspension containing toltrazuril and diclazuril and preparation method of suspension

A technology of toltrazuril and suspension, applied in the direction of liquid delivery, emulsion delivery, drug combination, etc., can solve problems such as death, slow weight gain of piglets, and incomplete treatment

Inactive Publication Date: 2015-01-14
QINGDAO VLAND BIOTECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

In recent years, studies have found that Isospora suis is the main cause of diarrhea in piglets. The clinical symptom of the disease is inflammatory necrosis of intestinal epithelial cells with villus atrophy, which seriously affects the digestion and absorption of piglets, resul

Method used

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Examples

Experimental program
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Effect test

example

[0022] Example: 5% Toltrazuril and Diclazuril Suspension in Water

[0023] [Prescription] Toltrazuril and Diclazuril 5%+2% (W / V)

[0024] Tragacanth Gum 0.8%(W / V)

[0025] Propylene Glycol 10%(W / V)

[0026] Poloxamer 0.3%(W / V)

[0027] Sodium Benzoate 0.2%(W / V)

[0028] Add pure water to 100% (V / V)

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Abstract

The invention belongs to the technical fields of veterinary antiparasitic agents and preparation methods of the veterinary antiparasitic agents, and particularly relates to a water suspension oral liquid containing toltrazuril and diclazuril and a preparation method of the water suspension oral liquid. The preparation comprises the following components: (a) toltrazuril and diclazuril crude drugs, (b) a suspending agent, (c) a wetting agent, (d) a preservative, and (e) a preservative. The water suspension oral liquid containing toltrazuril and diclazuril disclosed by the invention is prepared by adopting a dispersion method, and is a water suspension with an off-white color and slight viscosity. The suspension oral liquid containing toltrazuril and diclazuril developed according to the invention is good in stability, good in palatability, long in elimination half life and high in bioavailability, and can be used as a veterinary oral preparation.

Description

technical field [0001] The invention belongs to the technical field of veterinary anticoccidial drugs and preparation methods, and in particular relates to a preparation method of a suspension of toltrazuril and diclazuril. [0002] technical background [0003] Toltrazuril belongs to triazine compounds. Toltrazuril and diclazuril are the main metabolites of toltrazuril. It is used in veterinary clinics for coccidia infection of animals. [0004] Diclazuril is a triazine benzyl nitrile compound, which is a new type, high efficiency and low toxicity anticoccidiostat, widely used in chicken coccidiosis. The mechanism of action of diclazuril against coccidia is still unclear. The peak period of the main action on coccidia varies with different species of coccidia, such as the main action point on Eimeria tenella is in the sexual cycle of the second generation schizont coccidia. But the giant, Eimeria brucei schizont invalid. The point of action on Eimeria maxima is at the z...

Claims

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Application Information

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IPC IPC(8): A61K31/53A61K9/10A61P33/02
Inventor 郝智慧
Owner QINGDAO VLAND BIOTECH INC
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