Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Targeted aggregation-induced emission fluorescence compound, and preparation method and application thereof

A technology for aggregation-induced luminescence and complexes, which is applied in the field of targeted aggregation-induced luminescence fluorescent complexes and their preparation, achieving the effect of mild conditions

Inactive Publication Date: 2015-01-28
GUANGXI NORMAL UNIV
View PDF2 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although hyaluronic acid can be used as a carrier of malignant tumor drugs that target and recognize CD44 receptor overexpression, it has not been reported to combine hyaluronic acid with AIE phenomenon to obtain imaging reagents targeting tumor cells

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Targeted aggregation-induced emission fluorescence compound, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0020] The configuration concentration is 2×10 -5 MQA-TPE aqueous solution and HA aqueous solution with a concentration of 38.0 mg / ml; then mix the prepared two aqueous solutions according to the volume ratio of 2500, and shake for a few minutes.

preparation Embodiment 2

[0022] The configuration concentration is 2×10 -5 MQA-TPE aqueous solution and HA aqueous solution with a concentration of 38.0 mg / ml; then mix the prepared two aqueous solutions according to the volume ratio of 250, and shake for a few minutes.

preparation Embodiment 3

[0024] The configuration concentration is 2×10 -5 MQA-TPE aqueous solution and HA aqueous solution with a concentration of 38.0 mg / ml; then mix the prepared two aqueous solutions according to the volume ratio of 125, and shake for a few minutes.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a targeted aggregation-induced emission compound. The targeted aggregation-induced emission compound is a compound (QA-TPE / HA) composed of an aqueous solution of dibrominated 1,2-bis{4-[4-(N,N,N-trimethyl ammonium)butoxy]phenyl}-1,2-stilbene (QA-TPE) and an aqueous solution of hyaluronic acid (HA). The preparation method is characterized in that the aqueous solution of the QA-TPE and the aqueous solution of the HA are mixed at room temperature according to a certain ratio, and are shaken up. The compound overcomes the disadvantage of aggregation fluorescence quenching of traditional fluorescence materials, and has a targeting effect on cancer cells highly expressed by a CD44 receptor; and the preparation method has the advantages of simplicity, mild conditions, and realization of fluorescence emission and the loading of a substance having a targeting effect on the cancer cells through a one step process. The invention also relates to an application of the compound in the targeted identification of the tumor cells.

Description

technical field [0001] The invention relates to a biomedical material, in particular to a targeted aggregation-induced luminescent fluorescent compound and a preparation method and application thereof. Targeted aggregation-induced luminescent fluorescent complexes can be used as fluorescent markers for fluorescence imaging of targeted tumor cells. Background technique [0002] Aggregation Induced Emission (AIE) refers to a photophysical phenomenon in which a class of photochromophores emits weakly or even no light in the solution state, but the fluorescence is significantly enhanced in the solid state or in the aggregated state (Y. Y. Huang, F. Hu , R. Zhao, G. X. Zhang, H. Yang, D. Q. Zhang. Chem Eur J, 2013, 19: 1–8), the aggregation-induced luminescence phenomenon was first discovered by Professor Tang Benzhong. The main reason for the AIE phenomenon is that the attenuation of non-radiative energy caused by the internal rotation of molecules in the solution state is ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C09K11/06C09K11/02A61K49/00
Inventor 沈星灿谭雪友蒋邦平纪仕辰雷文琪
Owner GUANGXI NORMAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com