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Micro powder containing fenbendazole and preparation method thereof

A technology of compound fenbendazole micropowder and fenbendazole is applied in directions such as powder delivery, amide active ingredients, anti-infective drugs, etc., and can solve the problems of low cure rate, long treatment period, insignificant treatment effect, etc., and achieve cure The effect of high rate, improving drug efficacy and shortening treatment time

Inactive Publication Date: 2015-02-04
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention provides a micropowder containing fenbendazole and a preparation method thereof, which solves the problems that the current fenbendazole oral preparation has no obvious therapeutic effect, long treatment cycle and low cure rate

Method used

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  • Micro powder containing fenbendazole and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] To produce 100kg water-soluble micropowder containing fenbendazole, get 5kg fenbendazole, 2.5kg PVPK30, 2.5kg SDS, mix well, pulverize, cross 150 mesh sieve, add 90kg anhydrous glucose and mix, equal Incremental mixing is made evenly.

Embodiment 2

[0016] To produce 100kg of water-soluble micropowder containing fenbendazole, take 10kg of fenbendazole, 2.6kg of PVPK30, and 2.6kg of SDS, mix well, pulverize, pass through a 150-mesh sieve, add 84.8kg of anhydrous glucose and mix, equal Incremental mixing is made evenly.

Embodiment 3

[0018] To produce 100kg water-soluble micropowder containing fenbendazole, take 8kg fenbendazole, 2.75kg PVPK30, 2.75kg SDS, mix well, pulverize, pass through a 150 mesh sieve, add 86.5kg of anhydrous glucose and mix, equal Incremental mixing is made evenly.

[0019] All the other embodiments are carried out according to the preparation method of Example 1, and the composition of raw materials is shown in Table 1:

[0020] Table 1 Unit: Kilogram

[0021]

[0022] The micropowder containing fenbendazole of the present invention can also be compounded with other medicines to form water-soluble compound fenbendazole micropowder.

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Abstract

The invention discloses micro powder containing fenbendazole. The micro powder is composed of the following components in percentage by weight: 5-10% of fenbendazole, 2.5-2.75% of PVPK 30, 2.5-2.75% of SDS and the balance being anhydrous glucose. The micro powder containing fenbendazole disclosed by the invention has enhanced adsorptivity and solubility, and is easier to be absorbed by astrointestinal tract; and the micro powder can enhance efficacy and shorten treatment time, and is obvious in treatment effect and high in curing rate.

Description

technical field [0001] The invention relates to the field of anthelmintics for poultry and livestock, in particular to a micropowder containing fenbendazole and a preparation method thereof. Background technique [0002] Coccidiosis is a parasitic disease that damages the intestinal tract of poultry and livestock. Coccidiosis is a disease that many commercial poultry farmers in the United States fear, and fatal losses of 20% or more are common. Coccidiosis is not a problem in home-based poultry holdings which are usually small, but has become a serious threat as the number of poultry kept increases. [0003] The onset of coccidiosis is very sudden, and after an acute onset, only injections can be used for first aid, which requires certain professional knowledge to operate. For large-scale breeding plants, injection rescue is obviously not effective for large-scale infection. Therefore, prevention is the main priority for coccidiosis. [0004] Fenbendazole is a benzimidaz...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/4184A61K31/4704A61P33/02A61K31/18
Inventor 李亚娥李建正李凤娟朱丽萍
Owner ZHENGZHOU HOUYI PHARMA