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Micro-pipeline-based liquid droplet generation method

A micro-pipe and droplet technology, which is applied in the direction of granulating raw materials, mixing methods, chemical instruments and methods, etc., can solve the problems of high cost and difficulty in precise control of droplet volume, so as to improve accuracy and efficiency, avoid Evaporation effects, simplified extraction and effects of storage steps

Active Publication Date: 2015-02-04
BEIJING DAWEI BIOTECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, the above-mentioned methods rely on relatively complex fluid drive devices, which are costly and difficult to precisely control the droplet volume.

Method used

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  • Micro-pipeline-based liquid droplet generation method

Examples

Experimental program
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Embodiment 1

[0086] Figure 4 It is a schematic diagram of the operation steps of the droplet generation method provided in Example 1 of the present application. Figure 4 Among them, 1 is a quartz capillary, 2 is a reservoir, 3 is mineral oil, 4 is a pure water droplet, and 5 is pure water with an injection volume of 5 nanoliters. The inner diameter of the quartz capillary 1 is 25 microns, the outer diameter is 50 microns, and the length is 5 cm. Before use, the quartz capillary 1 is pre-silanized with dichlorodimethylsilane to make the mouth of the capillary hydrophobic. The upper end of the quartz capillary 1 is connected with a syringe pump (Harvard Apparatus, Pico Elite, not in Figure 4 Shown in ) connection, the connection gap is filled with epoxy resin glue to ensure airtightness. The syringe pump is equipped with a syringe with a volume of 10 microliters (not in Figure 4 shown in ). Before use, fill the syringe, Teflon thin tube, and quartz capillary 1 with pure water, and ch...

Embodiment 2

[0091] According to the method of Example 1, a droplet with a volume of 2.5 nanoliters was obtained; the difference was that the flow rate of the syringe pump was 60 nanoliters / minute, and the injection time was changed to 2.5 seconds.

Embodiment 3

[0093] According to the method of Example 1, a droplet with a volume of 2.5 nanoliters was obtained; the difference was that the flow rate of the syringe pump was changed to 30 nanoliters / minute, and the injection time was 5 seconds.

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Abstract

The invention provides a micro-pipeline-based liquid droplet generation method which comprises the following steps: firstly, providing a micro-pipeline with an opening in one end, wherein the micro-pipeline is full of a first liquid; providing an opened container with a second liquid; positioning the micro-pipeline above the liquid level of the opened container; enabling the micro-pipeline to move downwards from the part above the liquid level of the opened container, thereby enabling the opening of the micro-pipeline to contact and be fed into the second liquid, and positioning the first liquid at the opening of the micro-pipeline; subsequently enabling the micro-pipeline of which the opening enters the second liquid to move upwards to leave off the liquid level of the opened container, thereby dissociating the opening of the micro-pipeline from the second liquid, dissociating the first liquid at the opening of the micro-pipeline from the micro-pipeline, and forming liquid droplets in the second liquid, wherein the first liquid and the second liquid are two liquids which are not compatible with each other or two liquids with interface reaction. The liquid droplet generation method is simple and convenient, liquid droplets with controllable sizes can be formed, and the precision and the efficiency in generating large-scale liquid droplets are improved.

Description

technical field [0001] The present application relates to the technical field of measuring or distributing micro-volume liquids, in particular to a method for generating liquid droplets based on micro-channels. Background technique [0002] At the microscale, accurate manipulation of microliter to microliter level liquids is an important proposition in the research fields of modern engineering, physics, chemistry, materials science, microfabrication and bioengineering. In biochemical analysis, environmental monitoring It has a wide range of applications in medical and clinical testing and the synthesis and preparation of micro-nano materials. Traditional emulsion polymerization method (Bovey FA, ​​et al. Emulsion polymerization. New York: Interscience publishers 1955, 1-22), membrane emulsification method (Nakashima T, et al. Membrane emulsification by microporous glass. Key Engineering Mater 1991, 513: 61-61) and spray emulsification (Liu Y, et al.Mixing in a multi-inlet v...

Claims

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Application Information

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IPC IPC(8): B01L3/00B01J2/00B01J13/02B01F13/00B01F3/08
Inventor 杜文斌徐鹏董立兵
Owner BEIJING DAWEI BIOTECH LTD
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