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Isoflavone derivatives, and preparation method and application thereof

A technology of derivatives and isoflavones, which is applied in the field of isoflavone derivatives and its preparation, can solve the problems of unseen bell bean metabolic syndrome and diabetes research reports, etc.

Inactive Publication Date: 2015-02-11
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far, there is no research report on the treatment of metabolic syndrome and diabetes with bell bean extract

Method used

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  • Isoflavone derivatives, and preparation method and application thereof
  • Isoflavone derivatives, and preparation method and application thereof
  • Isoflavone derivatives, and preparation method and application thereof

Examples

Experimental program
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Embodiment

[0026] Take 20kg of the whole plant of bell bean, crush and add 100L of ethanol aqueous solution with a volume fraction of 95% for reflux extraction, each reflux extraction for 2 hours, and extract 4 times in total; combine the extracts, filter, and concentrate under reduced pressure; The paste was suspended in water, and the suspension was extracted several times with petroleum ether until the petroleum ether layer was nearly colorless; then the collected aqueous layer was extracted with ethyl acetate until the ethyl acetate layer was nearly colorless; the collected ethyl acetate was concentrated under reduced pressure. The ester layer is obtained as an ethyl acetate fraction; the obtained ethyl acetate fraction is subjected to silica gel column chromatography, followed by elution with petroleum ether, petroleum ether-ethyl acetate with a volume ratio of 1:0.2, and a collection volume ratio of 1: 0.2% of the petroleum ether-ethyl acetate eluent; concentrated under reduced pres...

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Abstract

The invention discloses isoflavone derivatives, and a preparation method and an application thereof. The derivatives are compounds with the structural formula represented by general formula I, II or III. In the above formulas, R1, R2, R3 are respectively selected from hydrogen, hydroxyl groups or C1-C10 alkoxy groups; R4 is a C1-C20 saturated alkyl group or a C1-C20 alkyl group with at least one of the following substituents: a hydroxyl group, an amino group, an alkylene group and a C1-C10 alkoxy group, and the alkoxy group can be linear or branched; and R5 is oxygen, sulfur or an imino group. The derivatives are prepared through solvent extraction, column chromatography separation and purification of a Crotalaria albida medicinal material or newly picked herb of Crotalaria albida as raw material. Experiments prove that the derivatives have a competitive antagonist effect on PPAR-gamma receptors and have a differentiation inhibition effect on 3T3-L1 cells, so the derivatives could be used to prepare medicines for treating metabolic syndromes as an active component.

Description

technical field [0001] The invention relates to isoflavone derivatives, a preparation method and application thereof, and belongs to the technical field of medicine. Background technique [0002] Metabolic syndrome is a common disease characterized by abnormal glucose and lipid metabolism, accompanied by increased low-density lipoprotein and decreased high-density lipoprotein cholesterol, and its common diseases are obesity, diabetes, hyperlipidemia and atherosclerosis Sclerosis, among which, diabetic patients are often complicated by hyperlipidemia, cardiovascular disease, diabetic nephropathy, diabetic neuropathy and other diseases. [0003] According to the World Health Organization, more than 220 million people are suffering from diabetes worldwide. Among them, China has become the country with the largest number of diabetics in the world, with a total of 92 million diabetic patients. According to the "New England Journal of Medicine" published on March 25, 2010 Accordin...

Claims

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Application Information

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IPC IPC(8): C07D407/04C07D407/12A61K31/352A61P3/10A61P5/50A61P3/06A61P3/04A61P9/10A61P9/12
CPCC07D407/04C07D407/12
Inventor 侴桂新孙秦虎张玉
Owner SHANGHAI UNIV OF T C M