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A kind of preparation method of terbinafine hydrochloride microcapsule antibacterial agent for shoes

A technology of terbinafine hydrochloride and microcapsules, applied in botany equipment and methods, fungicides, chemicals for biological control, etc., can solve the problems of poor antibacterial persistence, troublesome use, and inability to achieve durable antibacterial, etc. It achieves the effect of improving water washing resistance, high safety, and green and environmental protection in the preparation process

Active Publication Date: 2016-08-24
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Terbinafine hydrochloride cream has a good therapeutic effect on foot infection, beriberi, etc., but it is troublesome to use, and the antibacterial persistence is poor, and it cannot achieve the purpose of lasting antibacterial anytime and anywhere

Method used

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  • A kind of preparation method of terbinafine hydrochloride microcapsule antibacterial agent for shoes
  • A kind of preparation method of terbinafine hydrochloride microcapsule antibacterial agent for shoes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Step 1: configuration mass concentration is 2% chitosan aqueous solution respectively (chitosan obtains through degradation, and its molecular weight is about 3000), mass concentration is 2% gum arabic aqueous solution, mass concentration is 2% terbinaline hydrochloride Fen cream aqueous solution;

[0017] Step 2: the chitosan aqueous solution, gum arabic aqueous solution and terbinafine hydrochloride aqueous solution of step 1 gained are mixed according to the ratio of core wall 2:1, wall material ratio (chitosan / gum arabic) 1:1, mix The sequence is to first mix the gum arabic aqueous solution and the terbinafine hydrochloride solution, then add the chitosan solution, place the beaker in a constant temperature water bath, and stir for 15 minutes at a temperature of 40°C and a stirring speed of 400r / min;

[0018] Step 3: Use sodium hydroxide with a molar concentration of 0.1mol / L to adjust the pH value of the mixed solution obtained in step 2 to 5 to cause complex coace...

Embodiment 2

[0022] Step 1: configuration mass concentration is 2% chitosan aqueous solution respectively (chitosan obtains through degradation, and its molecular weight is about 3000), mass concentration is 2% gum arabic aqueous solution, mass concentration is 2% terbinaline hydrochloride Fen cream aqueous solution;

[0023] Step 2: the chitosan aqueous solution, gum arabic aqueous solution and terbinafine hydrochloride aqueous solution of step 1 gained are mixed according to the ratio of core wall ratio 1:1, wall material ratio (chitosan / gum arabic) 1:1, mix The sequence is to first mix the gum arabic aqueous solution and the terbinafine hydrochloride solution, then add the chitosan solution, place the beaker in a constant temperature water bath, and stir for 15 minutes at a temperature of 50°C and a stirring speed of 500r / min;

[0024] Step 3: Use sodium hydroxide with a molar concentration of 0.1 mol / L to adjust the pH value of the mixed solution obtained in step 2 to 5 to cause a comp...

Embodiment 3

[0028] Step 1: configuration mass concentration is respectively the chitosan aqueous solution of 3% (chitosan obtains through degradation, and its molecular weight is about 3000), mass concentration is 3% gum arabic aqueous solution, mass concentration is 3% terbinaline hydrochloride Fen cream aqueous solution;

[0029] Step 2: the chitosan aqueous solution, gum arabic aqueous solution and terbinafine hydrochloride aqueous solution of step 1 gained are mixed according to the ratio of core wall ratio 1:1, wall material ratio (chitosan / gum arabic) 1:1, mix The sequence is to first mix the gum arabic aqueous solution and the terbinafine hydrochloride solution, then add the chitosan solution, place the beaker in a constant temperature water bath, and stir for 15 minutes at a temperature of 40°C and a stirring speed of 400r / min;

[0030] Step 3: Use sodium hydroxide with a molar concentration of 0.1mol / L to adjust the pH value of the mixed solution obtained in step 2 to 4.5 to caus...

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Abstract

A preparation method of a terbinafine hydrochloride microcapsule antibacterial agent for shoes comprises the steps: with chitosan and Arabic gum as a wall material and a terbinafine hydrochloride emulsifiable paste as a core material, dispersing the terbinafine hydrochloride emulsifiable paste in a capsule wall material aqueous solution, regulating a pH value, allowing the positively charged chitosan and the negatively charged Arabic gum to generate an electrostatic effect, attracting each other, then making the solubility reduced, generating phase separation, forming a gel layer, precipitating the gel layer around the core material, and finally adding glutaraldehyde to make the obtained microcapsule cured. The prepared terbinafine hydrochloride microcapsule has uniform distribution of particle size, is regularly spherical in shape, can better penetrate into the interior of fiber, and achieves the purpose of lasting bacteria resistance whenever and wherever possible; and the prepared microcapsule also has antifungal and antibacterial performance, is more suitable for shoe material bacteria resistance, and has the characteristics of being simple and easy to implement.

Description

technical field [0001] The invention relates to a preparation method of microcapsules, in particular to a preparation method of terbinafine hydrochloride microcapsule antibacterial agent for shoes. Background technique [0002] Shoes are a must-have in people's daily life. During wearing, due to the airtightness of the shoe cavity, the germs on the skin of the feet multiply in large numbers, which can easily cause skin infections, and then cause foot diseases. With the progress of society and the continuous improvement of people's living standards, people have higher and higher requirements for the comfort performance and hygienic performance of shoes and boots. However, most of the existing antibacterial shoe materials have good antibacterial effects on typical bacteria such as Escherichia coli and Staphylococcus aureus, but have no obvious effect on fungi such as Candida albicans and Trichomonas rubrum that really cause foot diseases. [0003] Antibacterial microcapsules ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N33/04A01N25/28A01P3/00A01P1/00
Inventor 弓太生盛云霞李慧万蓬勃
Owner SHAANXI UNIV OF SCI & TECH
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