Iridium complex as well as preparation method and application thereof

A kind of technology of iridium metal complex and application, applied in the field of iridium metal complex and preparation thereof, can solve the problems such as no report found, and achieve the effect of simple preparation method, good anti-parasitic effect, and easy-to-obtain raw materials

Inactive Publication Date: 2015-03-11
GUANGXI UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The present invention attempts to use iridium metal instead of tradi

Method used

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  • Iridium complex as well as preparation method and application thereof
  • Iridium complex as well as preparation method and application thereof
  • Iridium complex as well as preparation method and application thereof

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preparation example Construction

[0031] A preparation method of iridium metal complex, which comprises the following steps:

[0032] Step 1. Take a 50ml round bottom flask, add 5g of meta-hydroxybenzaldehyde, dissolve it with 10ml of acetone, add 3.826g of anhydrous potassium carbonate, the solution is a pale yellow transparent solution, heat and stir at 45℃ to reflux for 10 minutes, then slowly drip Add 3.87ml of dimethyl sulfate, after reaction for 12h, spin the filtrate to dryness, add 2ml of deionized water, add 5ml of ethyl acetate for extraction, repeat the ethyl acetate extraction process 4 times, combine the ethyl acetate layer solution, add 10g of anhydrous The potassium carbonate is dried, and the solution is spin-dried to obtain m-methoxybenzaldehyde. Its structural formula is:

[0033]

[0034] Step 2. Dissolve 3g of m-methoxybenzaldehyde in 10ml of absolute ethanol, add 1.0g of 4-phenyl-3-thiosemicarbazide, reflux and stir at 65°C, react for 5h to obtain a purple solution, spin dry to 1ml, add 5ml et...

Embodiment 1

[0044] 1. Product preparation

[0045] Take a 50ml round bottom flask, add 5g of meta-hydroxybenzaldehyde, dissolve it with 10ml of acetone, add 3.826g of anhydrous potassium carbonate, the solution is a pale yellow transparent solution, heat and stir at 45℃ to reflux for 10 minutes, then slowly add disulfuric acid dropwise 3.87ml methyl ester, after 12h reaction, spin the filtrate to dryness, add 2ml deionized water, add 5ml ethyl acetate extraction, repeat the ethyl acetate extraction process 4 times, combine the ethyl acetate layer solution, add 10g anhydrous potassium carbonate to dry , Spin the solution to dryness to obtain m-methoxybenzaldehyde; dissolve 3g m-methoxybenzaldehyde in 10ml absolute ethanol, add 1.0g 4-phenyl-3-thiosemicarbazide, reflux and stir at 65℃ , React for 5 hours to obtain a purple solution, spin dry to 1ml, add 5ml ethanol and 5ml n-hexane, white crystals are precipitated, which is m-methoxybenzaldehyde 4-phenyl-3-thiosemicarbazide; weigh m-methoxy B...

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Abstract

The invention discloses an iridium complex as well as a preparation method and an application thereof. The iridium complex is monochloro-mono-meta-methoxybenzaldehyde-4-phenyl-3-thiosemicarbazide-pentamethyl cyclopentadienyl iridium (III) and can be applied to preparation of medicines for treating cancers, and the structural formula of the complex is shown in the specification.

Description

Technical field [0001] The invention relates to the field of chemical medicine, in particular to an iridium metal complex and its preparation method and application. technical background [0002] Since Rosenberg discovered that cisplatin has anti-tumor effects in 1967, cisplatin has become one of the three most widely used drugs for the treatment of cancer in the world. After decades of research by scientific researchers, several generations of platinum complexes such as carboplatin and oxaliplatin have been synthesized and used in clinics. However, dozens of anti-tumor drugs currently used in clinical chemotherapy or adjuvants only have a good curative effect on the treatment of some tumors. Therefore, the preparation of new metal complex antitumor drugs can provide more and better options for the treatment of tumor diseases, and has become a current research hotspot. The present invention attempts to use iridium metal instead of traditional platinum metal, and no relevant rep...

Claims

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Application Information

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IPC IPC(8): C07F17/02A61P35/00A61P33/00A61P33/06
CPCC07F17/02
Inventor 李培源苏炜霍丽妮陈睿王杰鹏
Owner GUANGXI UNIV OF CHINESE MEDICINE
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