Rhodium complex as well as preparation method and application thereof

A technology for rhodium complexes and uses, which is applied in the field of rhodium complexes and their preparation, can solve the problems of no reports and the like, and achieve the effects of simple preparation method, good bactericidal effect, and good tumor cell activity effect.

Inactive Publication Date: 2015-03-11
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention attempts to use rhodium metal to replace traditional platinum metal, but no relevant reports have been found so far

Method used

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  • Rhodium complex as well as preparation method and application thereof
  • Rhodium complex as well as preparation method and application thereof
  • Rhodium complex as well as preparation method and application thereof

Examples

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preparation example Construction

[0032] A kind of preparation method of rhodium complex, wherein, comprise the following steps:

[0033] Step 1, mix salicylaldehyde, acetone and anhydrous K 2 CO 3 Put it into a round-bottomed flask for mixing, reflux with magnetic stirring at 50-60°C, preferably at 55°C, and drop dimethyl sulfate with a concentration of 90-100% into the round-bottomed flask in 20-30min, Wherein preferably 15min and pure dimethyl sulfate, after reacting for 10-13 hours, add dropwise dilute hydrochloric acid to dissolve unreacted potassium carbonate, preferably 12 hours, then add saturated NaCl solution until the solution is separated, take out the organic phase, and Add NaOH solution to the organic phase, and the deep red oily substance at the bottom is o-methoxybenzaldehyde, and its structural formula is as follows:

[0034]

[0035] Step 2: Dissolve o-methoxybenzaldehyde in absolute ethanol and turn it into a light yellow solution, add 4-methyl-3-thiosemicarbazide to the light yellow so...

Embodiment 1

[0044] 1. Product preparation

[0045] Take 5g salicylaldehyde, 40ml acetone, 0.1g anhydrous K 2 CO 3 Put it into a round-bottomed flask, reflux with magnetic stirring at 55°C, and drop 4ml of dimethyl sulfate into the reaction flask in 20-30min, add 3ml dropwise after 12 hours of reaction, and dilute the unreacted hydrochloric acid with 1mol / L Potassium carbonate is dissolved, then mixed with saturated NaCl solution, the solution is layered, and the organic phase is taken, and 50ml, 2mol / L NaOH solution is added to the organic phase, and the deep red oily substance at the bottom is o-methoxybenzaldehyde; Oxybenzaldehyde was dissolved in 30ml of absolute ethanol to turn into a light yellow solution, and 1.2g of 4-methyl-3-thiosemicarbazide was added, stirred under reflux at 80°C, a large amount of light yellow powder precipitated after 1 hour, filtered , to obtain a white solid, which is o-methoxybenzaldehyde acetal 4-methyl-3-thiosemicarbazide; weigh o-methoxybenzaldehyde a...

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Abstract

The invention discloses a rhodium complex as well as a preparation method and application thereof. The rhodium complex is monochloride o-mono-methoxy benzaldehyde acetal 4-methyl-3-thiosemicarbazide-pentamethylcyclopetadienyl-rhodium (III), and the rhodium complex can serve as the application for preparing drugs for treating cancers. The structural formula of the rhodium complex is shown in the Specification.

Description

technical field [0001] The invention relates to the field of chemical medicine, in particular to a rhodium complex and its preparation method and application. technical background [0002] Since Rosenberg discovered that cisplatin has anti-tumor effects in 1967, cisplatin has become one of the three most widely used drugs for cancer treatment in the world. After decades of research by scientific researchers, several generations of platinum complexes such as carboplatin and oxaliplatin have been synthesized and applied clinically. However, dozens of anti-tumor drugs currently used in clinical chemotherapy or adjuvant therapy only have a good curative effect on the treatment of some tumors. Therefore, the preparation of new metal complex anti-tumor drugs, which can provide more and better options for the treatment of tumor diseases, has become a current research hotspot. The present invention attempts to use rhodium metal to replace traditional platinum metal, but no relevan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F17/02A61P35/00A61P33/00A61P33/06A61P31/04A61P31/10
CPCC07F17/02
Inventor 李培源苏炜霍丽妮陈睿
Owner GUANGXI UNIV OF CHINESE MEDICINE
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