Primer, probe, fluorescence PCR (Polymerase Chain Reaction) kit and method for detecting HLA (Human Leucocyte Antigen)-B*5801 genes
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SUZHOU KUANGYUAN MOLECULAR BIOTECH
- Publication Date
- 2015-03-11
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The invention belongs to the field of biomedical clinical molecular detection, in particular to primers, probes, fluorescent PCR kits and detection methods for HLA-B*5801 allele detection. Background technique
[0002] Human leukocyte antigen (HLA) is a group of genes located on chromosome 6. It is the gene complex with the highest allelic polymorphism among known genes so far. More than 2,700 alleles have been found in the world, although how many of them are Alleles are rare. HLA gene is the most complex genetic polymorphism system in humans, and its polymorphism distribution has obvious ethnic characteristics. So far, studies in Han Chinese from mainland China, Hong Kong, Taiwan, and Thailand have shown a strong association between the HLA-B*5801 allele and severe skin adverse reactions to the drug allopurinol. In European and Japanese races, the correlation is relatively low.
[0003] Allopurinol is an inhibitor of hypoxanthine oxidase, which ca...