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Wound healing composition

A wound healing and composition technology, applied in the field of wound healing, can solve the problems of high irritation, occasional allergic reaction, unpleasant odor, corrosiveness and toxicity, etc.

Inactive Publication Date: 2015-03-18
TAIWAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, tincture of iodine is highly irritating, corrosive and toxic when in contact with body cavities, mucous membranes or wounds
Tincture of iodine also has other undesired side effects that make it unsuitable for use in wound management, including the possibility of occasional allergic reactions, skin staining, and unpleasant odor

Method used

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  • Wound healing composition
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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0048] The preparation of example 1 composition of the present invention

[0049] Hyaluronic acid (HA) stock solutions were prepared by dissolving 1.5 g of hyaluronic acid with 100 KDa, 1,000 KDa, and 2,000 KDa respectively in 80 g of deionized water (DI water), followed by filtration for sterilization. Povidone-iodine (PI) stock solutions were prepared by adding 0.05 g povidone-iodine (PI) to DI water to a total weight of 100 g, followed by filtration for sterilization. By adding 0.75g KI 3 and 0.5 g of iodine were added in DI water to a total weight of 100 g to prepare KI 3 The stock solution was then filtered for sterilization (positive control). The following samples were prepared by diluting the above stock solutions followed by mixing the resulting solutions.

[0050]

example 2

[0051] Example 2 pH Stability of Compositions of the Invention

[0052] The following composition 10HA-KI was detected at different time points (day 0 to day 27) by a pH meter (EUTECH PH510) 3 、100HA-KI 3 , the pH values ​​of 10HA-PI and 100HA-PI, and the composition 10HA-KI 3 The results with 10HA-PI are shown in Figure 1(A) and with 100HA-KI 3 The results with 100HA-PI are shown in Figure 1(B). The pH values ​​of the above compositions at day 0 and day 27 are shown in Table 1.

[0053] Table 1

[0054]

[0055]

[0056] As shown in the table, including low molecular weight HA (100KDa) and KI 3 The composition (10HA-KI 3 ) has a pH change of about 17.8%, including high molecular weight HA (1,000KDa) and KI 3 The composition (100HA-KI 3 ) with a pH change of about 7.4%, and a composition containing low molecular weight HA (100KDa) and povidone-iodine (10HA-PI) had a pH change of about 6.6%, while a composition containing high molecular weight HA (1,000KDa) and po...

example 3

[0057] Example 3 The appearance of the composition of the present invention

[0058] The appearance of the newly prepared sample in Example 2 is light reddish brown. After storing the samples in Table 1 away from light and at room temperature for 5 months, the samples containing HA and KI 3 The composition of HA was yellow-brown, while the composition containing HA and povidone-iodine was still light reddish-brown, but the color of the sample with high molecular weight HA became darker (see figure 2 (A) and figure 2 (B)). Appearance analysis also showed that compositions comprising high molecular weight HA and PI were different from those comprising HA and KI 3 Compositions of complexes have significantly higher stability.

[0059] The formulation in the example of US 2005 / 0181025A1 was further used as a comparative experiment. The formulation is as follows:

[0060]

[0061] After storing it away from light and at room temperature for 5 months, it took on a yellow-br...

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Abstract

The invention discloses a composition comprising hyaluronic acid with a high molecular weight and povidone-iodine in low amount that has advantageous efficacy in enhancing wound healing and maintains high stability. Also disclosed is a method of using the composition of the invention in healing wounds.

Description

technical field [0001] The present invention relates to a wound healing composition and a method for wound healing. In particular, the composition of the invention comprises hyaluronic acid and povidone-iodine. Background technique [0002] In general, many people suffer from trauma to the skin (superficial or deep tissue) every year. There are many different types of skin wounds that vary in cause, severity, healing time, location, and more. For example, while some wounds heal quickly, i.e., acute, many wounds have a relatively long healing time, i.e., chronic, and may last for weeks, months, or even years, with some In some cases the wound may persist and never heal. Thus, the symptoms or manifestations of trauma vary and may vary from, for example, mild abrasions to more severe trauma, such as open skin wounds (eg, open sores, pustules, and ulcerations, and the like), and may debilitating. Wounds may be formed due to many different reasons, such as peeling and scrapi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/79A61P17/02A61P1/02A61P35/00A61P27/02A61P17/06A61K31/728
CPCA61K31/728A61K31/79A61K2300/00A61K9/06A61L26/0023A61P1/02A61P17/02A61P17/06A61P27/02A61P35/00A61P41/00
Inventor 林丽卿郑玉杲陈毓华江淑芳
Owner TAIWAN BIOTECH