Freeze-drying excipient packing and transferring system and production method thereof

A technology of freeze-drying shaping and delivery system, which is applied in the direction of freeze-drying transportation, packaging, and packaged food, and can solve problems such as inaccurate dosage, assembly and use of pre-filled dual-chamber syringes, and impact on experience

Active Publication Date: 2015-03-18
常州伟博海泰生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the double-aluminum packaging itself often does not have good support, and it needs to use other auxiliary packaging with a certain hardness to enhance the protection of the preparation; it is relatively cumbersome to open and use, which brings a certain sense of experience to the product. influences
In addition, the double aluminum packaging needs to be opened and mixed with its solvent before use. During the mixing process, the process of opening the package, mixing and exporting the mixed solution is relatively complicated, and bacteria are easily mixed in, causing secondary damage after opening the package. secondary pollution
[0004]Traditional pre-filled double-chamber syringes are mainly used for injection purposes. In order to avoid m

Method used

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  • Freeze-drying excipient packing and transferring system and production method thereof
  • Freeze-drying excipient packing and transferring system and production method thereof
  • Freeze-drying excipient packing and transferring system and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Vitamin C: Pullulan=5:1, 50 mg of the mixed powder is filled into a 0.4 milliliter molding mold in solid form, and then the remaining 10 mg is dissolved in 0.4 milliliters of water, filled into a molding mold containing the powder, and freeze-dried Finally, the obtained freeze-dried excipient preparation is loaded into the solid preparation cavity of the double-chamber mixing cavity of plastic material with a bypass 6, and then the piston 4 made of silica gel is assembled into the bottom of the solid preparation cavity of plastic material, Below the bypass 6; fill 2 milliliters of deionized water into the plastic liquid preparation chamber isolated by the piston 2 made of silica gel; then add the piston 2 made of silica gel, so that the liquid is completely stored in the liquid preparation chamber, and will not Seep out from between the silicone piston 4 and the silicone piston 2 to obtain a double-chamber mixing chamber containing a freeze-dried excipient and a solvent,...

Embodiment 2

[0082]EGF stock solution, add gelatin, hydrolyzed gelatin after thawing, be mixed with EGF (weight ratio) containing 5 / 100,000, gelatin+hydrolyzed gelatin solution containing 5%, fill into 0.1 milliliter molding mold, pack into after freeze-drying In the solid preparation chamber of a double-chamber transparent glass material with scale, then assemble the rubber piston 4 into the bottom of the solid preparation chamber and below the bypass 6; then fill 2 ml of 3% hyaluronic acid solution into the The liquid preparation cavity isolated by the rubber piston 2; then the rubber piston 2 is added, so that the liquid is completely stored in the liquid preparation cavity and will not seep from between the rubber piston 4 and the rubber piston 2, that is A double-chamber mixing chamber containing a freeze-dried excipient and a solvent is obtained, and a double-chamber mixer device is formed together with a transparent plastic accommodation chamber, a pushing chamber and a manual push r...

Embodiment 3

[0086] Panax notoginseng saponins: PVP=30mg: 15mg, prepared into a solution, filled into a 0.3ml molding mold, freeze-dried and packed into a double-chamber solid preparation chamber made of composite aluminum, and then the piston 4 made of silica gel was assembled into the The bottom of the solid preparation chamber, below the bypass 6; then fill 1 ml of deionized water containing natural essence into the liquid preparation chamber isolated by the piston 2 made of silica gel; then add the piston 2 made of silica gel to make the liquid complete Stored in the liquid preparation cavity, it will not seep from between the silicone piston 2 and the silicone piston 4, that is, a double-chamber mixing chamber containing freeze-dried excipients and solvents is obtained, and the container made of aluminum The cabin, the push cabin and the electric push rod piston together form a double-chamber mixer device.

[0087] When in use, put the electric push rod piston device 7, 8, 11 into the...

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Abstract

A lyophilized excipient formulation (5) packaging and delivery system and preparation method; the lyophilized excipient formulation (5) is used for food products, health foods, oral pharmaceuticals, topical pharmaceuticals, and cosmetics. The lyophilized excipient formulation (5) packaging and delivery system comprises a lyophilized excipient formulation (5), a solvent, and a packaging and delivery apparatus for said lyophilized excipient formulation (5) and solvent; said packaging and delivery apparatus contains a dual-chamber mixing device, the solvent and lyophilized excipient formulation (5) are stored in different chambers (N1, N2) of the dual-chamber mixing cavity (9) of the dual-chamber mixing device, and by means of the interaction of each component of the dual-chamber mixture device, the solvent and lyophilized excipient formulation (5) can be mixed and derived during use. The lyophilized excipient formulation (5) packaging and delivery system protects the stability of active ingredients, improves usage results, reduces potential side effects, prolongs shelf life, avoids contamination, is convenient to use, and reduces cost.

Description

technical field [0001] The present invention relates to a packaging and delivery system of a freeze-dried excipient and a preparation method thereof, in particular to a freeze-dried excipient applied to food, health food, oral medicine, external medicine and cosmetics, which is mixed with a solvent in The invention relates to a double-chamber mixing device and a delivery system which are stored separately in the same package and ready to use when used, and a corresponding preparation method thereof. Background technique [0002] Freeze-dried excipient preparation is a form of preparation prepared by freeze-dry excipient technology, which is formed by pouring the raw and auxiliary materials of the preparation into a molding mold and then undergoing a freeze-drying process. Because this type of preparation adopts the freeze-drying process, which can protect the heat-sensitive components from being destroyed, and the preparation itself has a large number of micropores and chann...

Claims

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Application Information

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IPC IPC(8): B65D81/32
CPCB65D81/32A61K9/19A23L3/44A61J1/2093A61J7/0053A61K8/9789A61K8/9794A61K47/32A61K47/36A61K47/42A61K2800/84A61K2800/88A61K2800/882A61Q19/00B65D81/3255
Inventor 李和伟
Owner 常州伟博海泰生物科技有限公司
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