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Magnetic hydroxyapatite bioceramic and preparation method thereof

A hydroxyapatite and bioceramic technology, applied in the field of biological materials, can solve the problems of dissimilar hard tissue structure and unsatisfactory effect, and achieve the effect of good biocompatibility, ideal effect and high mechanical strength

Inactive Publication Date: 2015-03-25
SUZHOU VIVOTIDE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] It can be seen that the magnetic hydroxyapatite bioceramic material provided by this technical scheme is a nano-hydroxyapatite / alumina composite bioceramic prepared by a deposition method. Nano-hydroxyapatite makes it have the dual properties of alumina and nano-hydroxyapatite, but because hydroxyapatite is only a coating material, its performance is mainly alumina matrix material, and the synthetic composite bioceramic and biological The hard tissue structure of the body is not similar, so it is not very effective as a substitute material for bone

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A magnetic hydroxyapatite bioceramic, comprising the following components in parts by mass:

[0028] 30 parts of hydroxyapatite, superparamagnetic nano Fe 3 o 4 6 parts of particles, 2 parts of magnesium oxide, 1 part of rutile nano-titanium oxide, 1 part of boron oxide and 6 parts of calcium oxide;

[0029] Among them, the ratio of Ga and P in hydroxyapatite is 1:1.67.

[0030] A preparation method of magnetic hydroxyapatite bioceramics, the preparation steps are as follows:

[0031] (1) Preparation of hydroxyapatite: CaHPO 4 with CaCO 3 Dosing according to the ratio of the amount of substances is 6:4; then carry out wet ball milling for 20 hours; pour the ball milled slurry into a container, add distilled water, and stir at a constant temperature of 90°C. After the reaction is completed, place it for precipitation A white precipitate of hydroxyapatite is obtained;

[0032] (2) Dry the above-mentioned hydroxyapatite precipitate, and then put it into a ball mill a...

Embodiment 2

[0038] A magnetic hydroxyapatite bioceramic, comprising the following components in parts by mass:

[0039] 55 parts of hydroxyapatite, superparamagnetic nano Fe 3 o 4 10 parts of particles, 6 parts of magnesium oxide, 4 parts of rutile nano-titanium oxide, 3 parts of boron oxide and 20 parts of calcium oxide;

[0040] Among them, the ratio of Ga and P in hydroxyapatite is 1:1.67.

[0041] A preparation method of magnetic hydroxyapatite bioceramics, the preparation steps are as follows:

[0042] (1) Preparation of hydroxyapatite: CaHPO 4 with CaCO 3 Dosing according to the ratio of the amount of substances is 6:4; then carry out wet ball milling for 20 hours; pour the ball milled slurry into a container, add distilled water, and stir at a constant temperature of 90°C. After the reaction is completed, place it for precipitation A white precipitate of hydroxyapatite is obtained;

[0043] (2) Dry the above-mentioned hydroxyapatite precipitate, and then put it into a ball mi...

Embodiment 3

[0049] A magnetic hydroxyapatite bioceramic, comprising the following components in parts by mass:

[0050] 42 parts of hydroxyapatite, superparamagnetic nano-NiFe 2 o 4 8 parts of particles, 4 parts of magnesium oxide, 2 parts of rutile nano-titanium oxide, 2 parts of boron oxide and 14 parts of calcium oxide;

[0051]Among them, the ratio of Ga and P in hydroxyapatite is 1:1.67.

[0052] A preparation method of magnetic hydroxyapatite bioceramics, the preparation steps are as follows:

[0053] (1) Preparation of hydroxyapatite: CaHPO 4 with CaCO 3 The ratio of the amount of substances is 6:4 to make ingredients; then carry out wet ball milling for 20 hours; pour the ball milled slurry into a container, add distilled water, and stir at a constant temperature of 90°C. After the reaction is completed, place it for precipitation A white precipitate of hydroxyapatite is obtained;

[0054] (2) Dry the above-mentioned hydroxyapatite precipitate, and then put it into a ball mi...

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Abstract

The invention relates to a magnetic hydroxyapatite bioceramic and a preparation method thereof, belonging to the field of biomaterials. The magnetic hydroxyapatite bioceramic is prepared from the following components in parts by weight: 30-55 parts of hydroxyapatite, 6-10 parts of magnetic nano particles, 2-6 parts of magnesium oxide, 1-4 parts of nano titanium oxide, 1-3 parts of boron oxide and 6-20 parts of calcium oxide. The preparation method of the magnetic hydroxyapatite bioceramic comprises the following steps: (1) preparing the hydroxyapatite; (2) mixing the components: (3) cold-press molding powder; (4) calcining at a high temperature; and (5) cooling and taking out the finished product. The magnetic hydroxyapatite bioceramic provided by the invention has high mechanical strength, good toughness and good biocompatibility, is non-irritating, can not be absorbed, can be used for patching and filling alveolar cavities and defected bone, can be used in brain surgery and can be further used for preparing ossicular chain material and cosmetic plastic material.

Description

technical field [0001] The invention belongs to the field of biological materials, in particular to a magnetic hydroxyapatite bioceramic and a preparation method of the bioceramic. Background technique [0002] Biomaterials are materials that repair, replace and regenerate body tissues. Due to the dissolution, corrosion and fatigue problems of stainless steel, the problems of poor stability and low strength of plastics exist. Bioceramic materials have been widely developed and have broad application prospects. [0003] Bioceramic materials are divided into bioinert ceramic materials and bioactive ceramic materials. Hydroxyapatite bioceramics is a kind of bioactive ceramics. The structure of hydroxyapatite is similar to that of biological bone. Therefore, synthetic hydroxyapatite bioceramics It has the same function as the hard tissue of the living body. [0004] With the continuous development of nanotechnology, nanomagnetic particles in nanomaterials have attracted conti...

Claims

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Application Information

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IPC IPC(8): C04B35/447C04B35/622
Inventor 李永超郭玉芹刘乐峰
Owner SUZHOU VIVOTIDE BIOTECH
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