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Dickkopf-1 expression modulating compositions and uses thereof

A technology of DICKKOPF-1 and composition, applied in the field of DICKKOPF-1 expression regulating composition and its use, can solve the problems of not identifying active ingredients of cell lysates, not recognizing cosmetic use and the like

Active Publication Date: 2015-03-25
AVON PROD INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, none of these prior cases recognized certain cosmetic uses and did not identify the active ingredient within the cell lysate

Method used

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  • Dickkopf-1 expression modulating compositions and uses thereof
  • Dickkopf-1 expression modulating compositions and uses thereof
  • Dickkopf-1 expression modulating compositions and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0188] Embodiment 1: Preparation of Huanghua Qijingu Extract

[0189] Auntia chinensis was collected and prepared into a 1:5 water infusion solution, wherein 200 mg of anhydrous plant material obtained 1 ml of extract. The leachate is a solvent-free aqueous preparation.

Embodiment 2

[0190] Example 2: Preparation of Yeast / Chrysanthemum chinensis fermented extract

[0191] Acanthus fragrans extract, as described above, was fermented with standard Pichia pastoris fermentation medium for a period of 72-140 hours until plant components were at least partially metabolized as assessed by optical density measurements. Crude Yeast / C. chinensis extract was dissolved and ground to release water-soluble cell wall components, including polysaccharides. Insoluble components were removed by filtration in order to improve color and odor. Save the final liquid fermented extract product.

Embodiment 3

[0192] Example 3: Tissue Culture of Fibroblasts

[0193] Adult human dermal fibroblasts (22 years old; Cascade; #5C0759) were grown in fibroblast growth medium containing 10% FBS, 1% L-glutamine and 1% P / S. Fibroblasts were seeded on 6-well culture plates at a density of 350,000 cells / well and cultured overnight. The supernatant was removed from each well. Serum-free medium (1% L-glutamine, 1% P / S, and no FBS) containing medium or yeast / A. chinensis ferment extract was added to the cells. Forty-eight hours after treatment, cell lysates were collected.

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Abstract

The present invention relates generally to compositions for topical application to the skin which comprise at least one DICKKOPF-1 expression modulator and the use of such compositions to provide benefits to the skin, including but not limited to lightening or darkening skin; treating hyper or hypopigmented skin; increasing or decreasing skin thickness; reducing or increasing skin hirsuteness; and / or changing skin phenotype from non-palmoplantar to palmoplantar.

Description

[0001] inventor [0002] U. Santanam 14 North Browning Avenue Tenafly, New Jersey 07670 [0003] Honkey 15 David Drive Whippany, NJ 07981 [0004] S. Yin 112 Harvest Lane Lincoln Park, New Jersey 07035 technical field [0005] The present invention generally relates to compositions comprising at least one modulator of DICKKOPF-1 expression for topical application to the skin, and uses of such compositions to provide benefits to the skin, including but not limited to: lightening the skin; Treat hyperpigmented skin; increase skin thickness; reduce hyperpigmentation; reduce skin hirsutism; and / or change skin phenotype from non-palmoplantar to palmoplantar. Background technique [0006] In the cosmetic industry, there is an increasing need to develop products that can be applied topically to the skin to improve the condition and appearance of the skin. Consumers concerned with reducing or delaying dermatological signs of chronologically- or hormonally-aged skin, as well as sk...

Claims

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Application Information

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IPC IPC(8): A61K8/00A61K36/00
CPCA61K9/0014A61K36/064A61K8/67A61K8/676A61Q15/00A61K8/735A61Q17/04A61Q19/00A61Q19/02A61Q19/06A61Q19/08A61K2800/522A61K8/9728A61P17/00A61P43/00
Inventor U·桑塔纳姆洪奇S·殷
Owner AVON PROD INC
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