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Application of dendrobium officinale polysaccharide in preparation of medicine for treating hypopigmentation skin disease

A technology of Dendrobium officinale polysaccharide and skin diseases, which can be applied to skin diseases, drug combinations, medical formulations and other directions, and can solve problems such as unreported documents.

Active Publication Date: 2019-11-29
THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dendrobium officinale polysaccharides have been reported in the literature to have the following effects: good DPPH scavenging ability, hydroxyl free radical scavenging ability and antioxidant ability, and can be used in the treatment of depression, pneumonia, constipation, hypertension, stroke, and hair growth promotion. However, the effect and mechanism of Dendrobium candidum polysaccharides in the treatment of hypopigmentation skin diseases such as vitiligo have not been reported in the literature.

Method used

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  • Application of dendrobium officinale polysaccharide in preparation of medicine for treating hypopigmentation skin disease
  • Application of dendrobium officinale polysaccharide in preparation of medicine for treating hypopigmentation skin disease
  • Application of dendrobium officinale polysaccharide in preparation of medicine for treating hypopigmentation skin disease

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Embodiment Construction

[0014] Below in conjunction with embodiment the present invention will be further described.

[0015] experimental method:

[0016] 1. Main materials

[0017] Dendrobium officinale polysaccharides with 90% purity were purchased from Xi'an Weite Biotechnology Co., Ltd.

[0018] 2. Cell culture:

[0019] At 37°C, 5% CO 2 Immortalized human melanocytes (PIG1 cells) were cultured in 254 (#M- 254-500, Gibco) medium. Murine melanoma cells (B16F10 cells) and immortalized human keratinocytes (Hacat cells) were cultured in DMEM (Hyclone) medium with 10% fetal bovine serum and 1% double antibody (Gibco).

[0020] 3. Cell viability assay (MTT assay)

[0021] Digest B16F10 cells with trypsin, prepare a single cell suspension with DMEM medium containing 10% fetal bovine serum, inoculate 2000 cells per well in a 96-well culture plate, with a volume of 200ul per well, after the cells adhere to the wall, different concentrations Dendrobium officinale polysaccharides (10ug / ml, 20ug / ml, ...

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Abstract

The invention belongs to the field of research on drugs for skin diseases, discloses application of dendrobium officinale Kimura ex Migo polysaccharide in preparing medicine for treating hypochromic skin disease, and particularly relates to the application in preparing the medicine for treating vitiligo.

Description

technical field [0001] The invention belongs to the field of drug research for skin diseases, in particular to drugs for treating hypopigmentation skin diseases. Background technique [0002] Vitiligo is a common depigmentation disease of the skin and mucous membranes, manifested as a decrease in the number or function of melanocytes in the skin and mucous membranes. The pathogenesis of vitiligo is related to autoimmune disorders, self-destruction of melanocytes, neuroendocrine disorders, oxidative stress, psychological emergency and other factors. Vitiligo not only seriously damages the patient's appearance, but also affects the normal life and social activities of the patient, which brings a great burden to the patient himself, the patient's family and the society. At present, external medicine, systemic medicine, optical therapy, surgical treatment and other methods are often used to treat vitiligo, but even with comprehensive treatment, it is still difficult for some pa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61P17/00
CPCA61K31/715A61K36/8984
Inventor 曾庆海陈静胡双海黄进华雷厉鲁建云夏芳康丽阳
Owner THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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