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Arterial hemostasisdressing and preparation method

A hemostatic dressing and arterial technology, applied in the field of medical devices, can solve problems such as changes in hemostatic properties, insignificant effects, and inability to stop bleeding at the rescue site, achieving high biological safety and avoiding ischemic necrosis.

Active Publication Date: 2015-04-01
LOGISTICS UNIV OF CAPF +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such products currently on the market are only effective on small blood vessels, but often have no obvious effect on bleeding from large arteries.
[0004] Chinese patents ZL02111437.4 and ZL02111593.1 disclose the preparation process of chitosan, collagen and calcium alginate composite non-woven fabric (sponge), used for wound repair, wound healing and hemostasis, mainly related to postoperative wound treatment, can not The role of hemostasis at the rescue site
The key to solving this problem is how to "composite" calcium alginate and chitosan, and how to change the hemostatic performance of the "composite" dressing, and a series of related issues have not been reported.

Method used

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  • Arterial hemostasisdressing and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A preparation method for an arterial hemostatic dressing, comprising the steps of:

[0038] (1) Calcium alginate fibers are cut into 50mm long calcium alginate staple fibers, and chitosan fibers with a deacetylation degree of more than 95% and a molecular weight of 200,000-300,000 Daltons are cut into 50mm long chitosan short fibers. Fiber;

[0039] (2) According to the ratio of mass ratio of 6.5:3.5, calcium alginate short fiber and chitosan short fiber are evenly mixed and then carded by a carding machine. It is made into a thickness of 4mm by acupuncture and a density of 0.18g / cm 3 Calcium alginate chitosan composite non-woven fabric;

[0040] (3) 3mm thick, density 0.14g / cm 3 Calcium alginate non-woven layer and 4mm thick with a density of 0.18g / cm 3 Calcium alginate-chitosan composite non-woven fabric layers are stacked and laminated by acupuncture to obtain an arterial hemostatic dressing.

Embodiment 2

[0042] A preparation method for an arterial hemostatic dressing, comprising the steps of:

[0043] (1) Calcium alginate fibers are cut into 40mm long calcium alginate short fibers, and the chitosan fibers with a deacetylation degree of more than 95% and a molecular weight of 200,000-300,000 Daltons are cut into 40mm long chitosan short fibers. Fiber;

[0044] (2) According to the mass ratio of 6:4, calcium alginate short fiber and chitosan short fiber are evenly mixed and then combed by a carding machine. It is made into a thickness of 3mm by acupuncture and a density of 0.14g / cm 3 Calcium alginate chitosan composite non-woven fabric;

[0045] (3) 3mm thick, density 0.14g / cm 3 Calcium alginate non-woven layer and 3mm thick with a density of 0.14g / cm 3 Calcium alginate-chitosan composite non-woven fabric layers are stacked and laminated by acupuncture to obtain an arterial hemostatic dressing.

Embodiment 3

[0047] A preparation method for an arterial hemostatic dressing, comprising the steps of:

[0048] (1) The calcium alginate fiber is cut into 60mm long calcium alginate short fiber, and the chitosan fiber with a deacetylation degree of more than 95% and a molecular weight of 200,000-300,000 Daltons is cut into a 60mm long chitosan short fiber. Fiber;

[0049](2) According to the ratio of mass ratio of 7:3, calcium alginate short fiber and chitosan short fiber are evenly mixed and then carded by a carding machine. It is made into a thickness of 4mm by acupuncture and a density of 0.18g / cm 3 Calcium alginate chitosan composite non-woven fabric;

[0050] (3) 4mm thick, density 0.18g / cm 3 Calcium alginate non-woven layer and 4mm thick with a density of 0.18g / cm 3 Calcium alginate-chitosan composite non-woven fabric layers are stacked and laminated by acupuncture to obtain an arterial hemostatic dressing.

[0051] When using the product of the present invention, the calcium alg...

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Abstract

The invention provides an arterial hemostasisdressing and a preparation method. The arterial hemostasisdressing comprises a calcium alginate non-woven fabric layer, wherein a calcium alginate and chitosancomposite non-woven fabric layer is connected to one surface of the calcium alginate non-woven fabric layer. Compared with variousalginate and chitosan hemostasisproducts sold in the market, the arterial hemostasisdressing can obviously shorten the arterial bleeding time and reduce the bleeding amount, and can be used for arterial bleeding at four limbs and special parts including the thorax and abdomen, armpits, groin and the like; compression binding is not required for arterial bleedingof four limbs, and generalbinding can be performed with bandage; for the special parts, hemostasis can be realized when the dressing is applied to a bleeding part with a hand for 2-3 min, and avascular necrosis easily caused by long-time binding is avoided; and a blood product and coarse powder are avoided, and the dressing is all-natural, non-toxic, degradable and high in bio-safety.

Description

technical field [0001] The invention relates to a hemostatic dressing for arterial bleeding and a preparation method thereof, belonging to the field of medical devices. Background technique [0002] Arterial hemorrhage, rapid and jet-like blood flow, is fatal. If the bleeding cannot be successfully stopped within 3 minutes, the patient will face death. A survey by the US military found that 90% of the soldiers killed in action died before being sent to the hospital, 1 / 2 of them died of hemorrhage, and 1 / 4 died within 5-10 minutes of being injured. Therefore, timely and effective control of bleeding before the injury is sent to the hospital and prevention of wound infection at the earliest stage can not only win valuable time for hospital treatment, but also create favorable conditions for the later recovery of the wounded, so it has become the focus of on-site first aid. Two focal points. [0003] There are two main first aid methods on the scene of arterial bleeding: one ...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44B32B9/02
Inventor 李灵芝刘璐褚加冕韩香陈达永梁林顾军褚省吾
Owner LOGISTICS UNIV OF CAPF
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