Oxybenzazole hydrochloride ophthalmic gel and preparation method thereof

A technology of oxybenzazole hydrochloride ophthalmic and oxybenzazole hydrochloride, which is applied in the field of oxybenzazole hydrochloride ophthalmic gel and its preparation, to achieve the effects of high affinity, prolonged action time and high bioavailability

Active Publication Date: 2017-09-26
YUNNAN PHYTOPHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the very effective protective mechanisms of the eyes such as tearing and blinking reflex, the medicine dripped into the eye is quickly eliminated from the front area of ​​the cornea, and the biological barrier function of the cornea restricts the medicine from reaching the target tissue in the eye
Therefore, there are certain limitations in the solution-type eye drops

Method used

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  • Oxybenzazole hydrochloride ophthalmic gel and preparation method thereof
  • Oxybenzazole hydrochloride ophthalmic gel and preparation method thereof
  • Oxybenzazole hydrochloride ophthalmic gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Mix 0.1 g of sodium hyaluronate, 1.5 g of carbomer and 0.1 g of Tween-80 with water for injection, mix and dissolve, add 0.1 g of sodium hydroxide and stir to obtain a matrix solution; Dissolve in water for injection, then add 0.3 g of ethyl paraben, 0.1 g of sodium chloride, 1 g of sodium thiosulfate and 0.5 g of ethylenediaminetetraacetic acid, mix well, add to the above matrix solution, add water for injection to 1L, microporous Filter through a membrane, sterilize, and shake well.

Embodiment 2

[0027] Mix and dissolve 15 g of poloxamer and 10 g of propylene glycol with water for injection, add 10 g of disodium hydrogen phosphate and 10 g of sodium dihydrogen phosphate, and stir to obtain a matrix solution; in addition, weigh 3 g of oxybenzazole hydrochloride, dissolve in water for injection, and then add 0.1 g of benzalkonium chloride, 50 g of glucose, 3 g of dimercaptoethyl glycine and 2 g of sodium metabisulfite, mix well, add to the above matrix solution, add water for injection to 1 L, filter through a microporous membrane, sterilize, and shake well after packaging. have to.

Embodiment 3

[0029] Mix and dissolve 0.1 g of xanthan gum and 5 g of glycerol with water for injection, add 10 g of triethanolamine and stir well to obtain a matrix solution; also weigh 1 g of Hydroxybenzazole Hydrochloride, dissolve in water for injection, and then add 0.1 g of benzalkonium bromide , 12g of borax, 2g of sodium bisulfite and 2g of diethyltriaminehexaacetic acid, mix well, add to the above matrix solution, add water for injection to 1L, filter through a microporous membrane, sterilize, divide and shake well.

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Abstract

The invention relates to an oxybenzazole hydrochloride ophthalmic gel and a preparation method thereof. The preparation method comprises the following steps: adding a matrix and a solubilizer in a recipe amount to water for injection, mixing, swelling or dissolving, and then adding a pH adjusting agent and stirring to obtain a matrix solution ; Weigh oxybenzazole hydrochloride according to the prescription amount, dissolve it in water for injection, add preservatives, isotonicity regulators and antioxidants, mix well, then add it to the base solution, add water for injection to 1L, shake well , filtered through a microporous membrane, sterilized, and packaged. Among them, Hydroxybenzazole Hydrochloride 0.01~3g, Base 0.1~20g, pH Adjuster 0.1~20g, Solubilizer 0.1~20g, Isotonicity Adjuster 0.1~50g, Preservative 0.01~8g, Antioxidant 0.05~5g. The prepared product can not only reduce the frequency of medication and avoid the loss and loss of the medication in the eye, but also can significantly improve the effect of medication for treating epidemic hemorrhagic conjunctivitis and shorten the course of the disease.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a hydroxybenzazole hydrochloride ophthalmic gel and a preparation method thereof. Background technique [0002] Acute hemorrhagic conjunc- Epidemic infectious eye disease. The main pathogens that cause acute hemorrhagic conjunctivitis are enterovirus type 70 and coxsackie virus group A type 24 variants, and adenovirus type 11 can also cause the disease. Hydroxybenzazole hydrochloride can selectively inhibit the picornavirus polymerase of infected cells, 50μg / ml can effectively inhibit various strains of human enterovirus, coxsackie virus and poliovirus; 10μg / ml can inhibit Acute epidemic hemorrhagic keratitis. The mechanism of anti-picornavirus is generally believed to be the inhibition of the RNA-dependent RNA polymerase of viral coding in infected cells, which hinders the synthesis of viral RNA, thereby exerting a virus-inhibiting effect. Currently, there are h...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K9/06A61K31/4184A61P27/02A61P31/14
Inventor梅艳李俊
OwnerYUNNAN PHYTOPHARML