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Ophthalmic composition containing diquafosol or salt thereof, vinyl-based polymer and cellulose-based polymer

A diquafosol, vinyl-based technology, applied to containing diquafosol or a salt thereof, can solve the problems of poor eye drop compliance, patients unable to obtain expected results, frequent eye drop, etc., to improve eye drop compliance , strong dry eye treatment effect, the effect of reducing the number of eye drops

Pending Publication Date: 2021-10-19
SANTEN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are cases where it is difficult to instill eye drops regularly and frequently in daily life, so there are patients who cannot obtain the expected effect due to poor eye instillation compliance

Method used

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  • Ophthalmic composition containing diquafosol or salt thereof, vinyl-based polymer and cellulose-based polymer
  • Ophthalmic composition containing diquafosol or salt thereof, vinyl-based polymer and cellulose-based polymer
  • Ophthalmic composition containing diquafosol or salt thereof, vinyl-based polymer and cellulose-based polymer

Examples

Experimental program
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Effect test

Embodiment

[0101] The results of pharmacological tests and preparation examples are shown below, but these examples are for better understanding of the present invention and do not limit the scope of the present invention.

[0102] [test 1]

[0103] Normal male white rabbits were used to evaluate changes over time in the amount of tears after instilling the present composition.

[0104] (drug preparation method)

[0105] Eye drops 1:

[0106] According to the prescription table shown in Table 1, eye drop 1 (in Table 1, the unit is g / 100mL) was prepared. That is, diquafosol sodium (9 g), sodium hydrogen phosphate hydrate (0.6 g), edetate sodium hydrate (0.03 g) and sodium chloride (1.35 g) were dissolved in sterilized purified water to obtain 50 mL of 6 times thick liquid. In addition, after mixing 10 mL of the 6-fold concentrated solution and 5 mL of sterilized purified water, PVP K30 (1.2 g) was dissolved, and then, a pH adjuster was added appropriately to adjust the pH to 7, and 20...

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Abstract

Provided is an ophthalmic composition containing diquafosol or a salt thereof, a vinyl-based polymer and a cellulose-based polymer. Also provided is an agent for preventing or treating dry eyes, which contains diquafosol or a salt thereof, a vinyl-based polymer and a cellulose-based polymer. These aqueous dissolution type eye drops for treating dry eye contain 3% (w / v) of diquafosol sodium, hydroxyethyl cellulose and polyvinylpyrrolidone having a K value of 30, and are characterized in that 1-2 drops are administered to the eyes three times per day.

Description

technical field [0001] The present invention relates to an ophthalmic composition containing diquafosol or a salt thereof, a vinyl-based polymer, and a cellulose-based polymer. Background technique [0002] Diquafosol is also known as P 1 ,P 4 - Diquafosol sodium as its salt as "DIQUAS (注册商标) Eye Drops 3%" (hereinafter also referred to as "DIQUAS (注册商标) eye drops") for the treatment of dry eye syndrome (Japanese Patent No. 3651707 (Patent Document 1), DIQUAS ( 注册商标) 3% Drug Instructions for Eye Drops (Non-Patent Document 1)). On the other hand, DIQUAS ( 注册商标 ) The usage and dosage of the eye drops is usually 6 times a day, 1 drop each time, and the eyes are instilled (Non-Patent Document 1). However, it is difficult to regularly and frequently instill eye drops in daily life, so there are patients who cannot obtain the expected effect due to poor eye instillation compliance. [0003] As an attempt to search for a new dry eye treatment agent having a higher tear volume...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P27/02A61P27/04A61K9/08A61K47/32A61K47/38A61K31/7072
CPCA61K47/32A61P27/04A61P27/02A61K9/08A61K31/6615A61K9/0048A61K31/7084A61K47/38A61K31/7072A61K31/7042
Inventor 森岛健司浅田博之桃川雄介神村明日香远藤健一
Owner SANTEN PHARMA CO LTD
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