Application of fructose in antiepileptic drug preparation

Abstract

The invention relates to new application of drugs, and provides application of fructose in antiepileptic drug preparation. A LiCl-Pilo epileptogenic rat model is utilized for carrying out a blind method pharmacodynamic test on five kinds of different drugs including the fructose, fructose diphosphate, sodium valproate sustained release tablets, fructose diphosphate+fructose (1:1) and fructose diphosphate+fructose (1:1), and a result indicates that the fructose is superior to the other drugs, the anti-epileptic effect of the fructose is more excellent than that of the fructose diphosphate, and the anti-epileptic effect of independent use of the fructose is more excellent than that of fructose and fructose diphosphate combination drugs. The fructose can be used for preparing the anti-epileptic drugs, new drugs are provided for epilepsy treatment, the fructose is used for preparing the anti-epileptic drugs, active ingredients are single, the medical dosage is reduced, the toxic and side effect is small, the drugs can be taken by a patient conveniently, and great clinical application value is achieved.

Description

technical field [0001] The invention relates to medicines, in particular to new uses of medicines, and in particular to the application of fructose in the preparation of antiepileptic medicines. Background technique [0002] Epilepsy is a brain disorder characterized by the persistence of permanent changes in the brain that produce seizures, with corresponding neurobiological, cognitive, psychological, and sociological consequences. There are about 70 million epilepsy patients in the world, of which more than 90% are located in low- and middle-income countries. The incidence rate is second only to migraine, stroke, and Alzheimer's disease, and it has become a common chronic disease that can affect people of all ages. especially in childhood and adolescence. According to epidemiological surveys, the prevalence of epilepsy is increasing year by year, causing great harm and impact on individuals, families, and society. At present, epilepsy has become a complex neurological dis...

AI Technical Summary

Problems solved by technology

[0006] Application No. CN 103599115A Chinese patent application discloses the application of a composition in the preparation of antiepileptic drugs, providing a composition containing 1,6-diphosphate fructose, fructose and borneol in the preparation of antiepileptic drugs The patent mainly states that fructose and borneol can increase the level of fructose 1,6-diphosphate (sodium fructose diphosphate) in the brain through different mechanisms, and the combination of the two can promote the entry of fructose 1,6-diphosphate into the brain. The brain complements each other, thereby further enhancing the efficacy of the main drug fructose sodium 1,6-diphosphate in the treatment of epilepsy, but the patent does not explain the antiepileptic effect of fructose

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