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Traditional Chinese medicinal composition and its application in defecation promotion

A composition and traditional Chinese medicine technology, applied in the field of traditional Chinese medicine compositions, can solve the problems of huge toxicity, restricting the wide application and export of Qingxie Pills, complex interaction mechanism, etc., and achieve the effect of eliminating obstacles and stable application effect.

Active Publication Date: 2015-04-22
湖南中医药高等专科学校
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complex mechanism of mutual synergy between Chinese herbal medicines, cinnabar is used together with rhubarb, baicalin, and citrus aurantium, and the specific role of cinnabar in antipyretic and defecation has not yet been clearly explained; at the same time, cinnabar It is red mercury, which mainly contains mercury sulfide (HgS). It will accumulate in the body after three days of medication. Although most of the cinnabar is mainly excreted through the intestinal tract, the excretion of mercury accumulated in the tissue may be excreted through the kidneys. Long-term use is harmful to humans. The toxicity of cinnabar is huge and multifaceted. The adverse reactions of cinnabar or Chinese patent medicines containing cinnabar are increasingly attracting people's attention. There have been many reports on related research. Wide application and export of Qingxie pills

Method used

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  • Traditional Chinese medicinal composition and its application in defecation promotion
  • Traditional Chinese medicinal composition and its application in defecation promotion
  • Traditional Chinese medicinal composition and its application in defecation promotion

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] 1. Experimental materials

[0014] 1.1 Experimental animals: 170 ICR mice, half male and half male, SPF grade, 18-22g, provided by Hunan Slack Jingda Experimental Animal Co., Ltd., certificate number: No.43004700002381; 70 SD rats, half male and half male , SPF grade, 180~220g, certificate number: No.43004700004026, breeding environment: room temperature 20℃~26℃, relative humidity 50%~70%, clean and quiet.

[0015] 1.2 Experimental drugs: (1) Self-made Qingxie pill (referred to as "No. 1 drug"): the prescription consists of 826g of rhubarb, 165g of skullcap, 83g of Citrus aurantium, 17g of licorice, and 14g of cinnabar powder. The above five flavors, except cinnabar powder, the other four flavors such as rhubarb, are crushed into fine powder, sieved, mixed evenly, pilled with water, dried, coated with cinnabar powder, dried and polished. The batch number is 20130811-1. (2) Self-made traditional Chinese medicine composition (referred to as "No. 2 medicine"): except that...

Embodiment 2

[0040] Embodiment 2: Stability experiment of curative effect

[0041] 1. Experimental method: adopt randomized controlled experiment method

[0042] A total of 100 outpatients with food stagnation and constipation in the outpatient clinic met the diagnostic criteria in the "Diagnostic and Curative Criteria for Diseases of Traditional Chinese Medicine" promulgated by the State Administration of Traditional Chinese Medicine in June 1994. They were divided into two groups by random method, 50 cases were treated with "No. 1 medicine" prescription, and 50 cases were treated with "No. 2 medicine" prescription. Each group has 26 males and 24 females, aged 14 to 57 years old, with an average of 29.7±10.6 years old, and the course of disease is 0.5 to 3 years. All patients have varying degrees of decreased defecation frequency, dry and hard stool, and / or difficulty in defecation . There were no significant differences in gender, age, and course of disease among the groups (P>0.05). ...

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Abstract

The invention discloses a traditional Chinese medicinal composition and its application in fever relief and defecation promotion. The traditional Chinese medicinal composition comprises 826g of Rheum officinale, 165g of Radix Scutellariae, 83g of Immature Bitter Orange and 17g of licorice root. The traditional Chinese medicinal composition has a stable application effect in the preparation of fever relief and defecation promotion medicines. A liver-fire clearing pill used as an official book prescription for a long term is creatively improved in the invention, an important component cinnabar in the pill, accepted as an assistant by technicist in the technical field, is removed to obtain the new composition, and the composition has the efficacies of heat clearing, bowel relaxing and stagnation relieving, can well be applied to treat constipation due to sthenia heat of large intestine, production of heat due to retention of food, and food stagnation, eliminates toxic influences due to cinnabar, and has stable medicinal effects.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine compositions, more specifically, to a traditional Chinese medicine composition and its application in antipyretic and defecation promotion. Background technique [0002] Qingxie Pill is a commonly used clinical prescription, which is recorded in the 2010 edition of "Chinese Pharmacopoeia" (Part One). The prescription is composed of 5 traditional Chinese medicines: rhubarb, scutellaria, citrus aurantium, licorice, and cinnabar. The specific prescription is 826g of rhubarb, 165g of baicalin, 83g, licorice 17g and cinnabar powder 14g, have the effects of clearing away heat, laxative, and eliminating stagnation, and are effective medicines for constipation caused by excessive heat in the large intestine or food accumulation to transform heat, and to treat food stagnation. In the prescription, it is believed that rhubarb is used to settle the bitter cold, good at clearing the exces...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61P29/00A61P1/10
Inventor 李辉
Owner 湖南中医药高等专科学校
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