Miniature administration and blood sampling system of jugular vein of rat
A jugular vein and drug delivery technology, which is applied in medical science, sensors, and equipment for restraining animals, etc., can solve problems that cannot be promoted in China, restrict scientific research and development, and expensive experiments
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Embodiment 1
[0013] according to figure 1 Make a fixture suitable for dynamically administering drugs to animals and taking blood. The ratios of the length and height of the hollow screw (1) with the chassis are respectively set to 4:3, 2:1 and 3:1, and no water-absorbing pad (5 ), (1) and (2) are connected by a plug-in buckle design, the length of the silicone tube is 25cm, and it is fixed with the fixing clip (4). In actual use, after fixing the rat with a hollow screw (1) with a chassis whose length to height ratio is 4:3, the layout on the chassis (1) is too compact (there is a silicone tube (3) and a fixing clip (4), and (2)), it is inconvenient to implement in the operation of taking blood after administration; after the rats whose length and height ratio of the hollow screw (1) with the chassis is 2:1 are fixed, the rats The activity is normal; the ratio of the length to the height of the hollow screw (1) with the chassis is 3:1. After the rat is fixed, the chassis (1) is too wide ...
Embodiment 2
[0015] according to figure 1 Make a fixture suitable for dynamic drug administration to animals and take blood. The length of the silicone tube (3) is 25-35cm, divided into three groups of 25cm, 30cm, and 35cm. The connections of (1) and (2) use plastic plug-in cards respectively Buckle design and screw connection, other designs are the same. But in the actual use process, due to the long-term feeding process of rats (about 1 month), along with the growth of rats' body weight, the 25cm silicone tube (3) will wear the fur of the rat's neck, which is harmful to the rats. damage; 30 c The silicone tube (3) of m was bitten off after the overnight operation of the rat, while the silicone tube (3) of 35 cm broke free after the overnight operation of the rat. However, the design of the plastic plug-in buckle is not easy to use because of the poor elasticity of the plug-in buckle due to frequent plugging and unplugging after taking blood for one week after continuous drug administra...
Embodiment 3
[0017] according to figure 1 Make a fixture that is suitable for dynamic drug administration to animals and take blood. The water-absorbing pad (5) of legend 1 is divided into use and non-use two groups, and other designs are all the same. Absorbent pad (5) is a layer containing 0.11mg / cm 2 The protective composite pad composed of benzalkonium chloride yellow isolation permeable membrane has the effect of sterilization and anti-inflammation, has a hole in the center, and is adhered to the chassis (1) by adhesive tape. However, in actual use, the animal group model without the waterproof pad (5) had an inflammation rate of 10 / 12, while the animal group model with the waterproof pad (5) had no inflammation phenomenon.
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