Miniature administration and blood sampling system of jugular vein of rat

A jugular vein and drug delivery technology, which is applied in medical science, sensors, and equipment for restraining animals, etc., can solve problems that cannot be promoted in China, restrict scientific research and development, and expensive experiments

Inactive Publication Date: 2015-04-29
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the components of intravenous catheterization are imported finished products, and their high price prevents such experiments from being promoted in China, which limits the development of scientific research

Method used

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  • Miniature administration and blood sampling system of jugular vein of rat
  • Miniature administration and blood sampling system of jugular vein of rat
  • Miniature administration and blood sampling system of jugular vein of rat

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] according to figure 1 Make a fixture suitable for dynamically administering drugs to animals and taking blood. The ratios of the length and height of the hollow screw (1) with the chassis are respectively set to 4:3, 2:1 and 3:1, and no water-absorbing pad (5 ), (1) and (2) are connected by a plug-in buckle design, the length of the silicone tube is 25cm, and it is fixed with the fixing clip (4). In actual use, after fixing the rat with a hollow screw (1) with a chassis whose length to height ratio is 4:3, the layout on the chassis (1) is too compact (there is a silicone tube (3) and a fixing clip (4), and (2)), it is inconvenient to implement in the operation of taking blood after administration; after the rats whose length and height ratio of the hollow screw (1) with the chassis is 2:1 are fixed, the rats The activity is normal; the ratio of the length to the height of the hollow screw (1) with the chassis is 3:1. After the rat is fixed, the chassis (1) is too wide ...

Embodiment 2

[0015] according to figure 1 Make a fixture suitable for dynamic drug administration to animals and take blood. The length of the silicone tube (3) is 25-35cm, divided into three groups of 25cm, 30cm, and 35cm. The connections of (1) and (2) use plastic plug-in cards respectively Buckle design and screw connection, other designs are the same. But in the actual use process, due to the long-term feeding process of rats (about 1 month), along with the growth of rats' body weight, the 25cm silicone tube (3) will wear the fur of the rat's neck, which is harmful to the rats. damage; 30 c The silicone tube (3) of m was bitten off after the overnight operation of the rat, while the silicone tube (3) of 35 cm broke free after the overnight operation of the rat. However, the design of the plastic plug-in buckle is not easy to use because of the poor elasticity of the plug-in buckle due to frequent plugging and unplugging after taking blood for one week after continuous drug administra...

Embodiment 3

[0017] according to figure 1 Make a fixture that is suitable for dynamic drug administration to animals and take blood. The water-absorbing pad (5) of legend 1 is divided into use and non-use two groups, and other designs are all the same. Absorbent pad (5) is a layer containing 0.11mg / cm 2 The protective composite pad composed of benzalkonium chloride yellow isolation permeable membrane has the effect of sterilization and anti-inflammation, has a hole in the center, and is adhered to the chassis (1) by adhesive tape. However, in actual use, the animal group model without the waterproof pad (5) had an inflammation rate of 10 / 12, while the animal group model with the waterproof pad (5) had no inflammation phenomenon.

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PUM

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Abstract

The invention discloses a miniature administration and blood sampling system of the jugular vein of a rat, comprising a cored screw with a base plate, a nut, a silicone tube, a fixation clamp, an absorbent pad, a catheter, a plug, a flat end needle and an injector. In the system, the nut is in threaded connection with the cored screw, round holes are formed around the base plate, the silicone tube is connected with the base plate through the round holes and is fixed through the fixation clamp, when in fixation, the silicone tube is in an x-shaped cross and passes through the chest of the rat, the base plate is fixedly arranged on the back part of the rat, and the position of the fixation clamp on the silicone tube is adjusted according to the rat individual, so that the base plate is fixed on the back part of the rat. The absorbent pad is arranged on the lower part of the base plate, is connected with the base plate through glue, and has the effects of hemostasis and anti-inflammation; the catheter is a biocompatible silicone tube, one end of the catheter is in the jugular vein of the rat, the other end of catheter is wound to the back part of the rat along the lower side of the neck skin of the rat, the top of the catheter is provided with a plug, and the catheter is arranged in the cored screw to be fixed. When the flat end needle and the injector are used for administrating and sampling blood to the rat, the plug is removed, and the flat end needle and injector are connected with the jugular vein through the catheter.

Description

technical field [0001] The present invention relates to a rat miniature jugular vein drug administration and blood collection system, in particular to a silicone tube with variable length that can be used for experiments in the fields of physiology, biochemistry, pharmacology, etc. Adjustable back fixation device suitable for long-term administration of rat jugular vein indwelling catheter for blood collection. Background technique [0002] Domestic blood collection methods mainly include blood collection from the retro-orbital venous plexus, tail vein blood collection, and carotid artery blood collection. Rats cannot avoid a relatively intense physiological state in this type of blood collection method, and the body’s metabolism at this time will be reduced. The experimental data of cytokines and hormones in the serum cannot fully explain the changes in the body of rats before and after administration. The method of long-term blood collection through catheterization in the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D7/00A61D3/00A61B5/153
CPCA61B5/15003A61B5/153A61D3/00A61D7/00
Inventor 于瑞莲吕高虹许金国杨云菲徐开成
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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