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Body-heat-excited polylactic-acid-base biodegradable shape memory material, and preparation method and application thereof

A polylactic acid-based, memory material technology, applied in the field of biomedical polymer materials, can solve the problems of complex preparation process, environmental pollution, human harm, etc., and achieve the effects of simple preparation process, good biological safety, and improved toughness

Active Publication Date: 2015-04-29
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] (2) Although the shape recovery temperature of polylactic acid-based shape memory materials prepared by the copolymerization method can be adjusted to around body temperature, the preparation process is complicated and the cost is high, and the preparation process uses toxic reagents, which are harmful to the human body and pollute the environment

Method used

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  • Body-heat-excited polylactic-acid-base biodegradable shape memory material, and preparation method and application thereof
  • Body-heat-excited polylactic-acid-base biodegradable shape memory material, and preparation method and application thereof
  • Body-heat-excited polylactic-acid-base biodegradable shape memory material, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] In this example, polylactic acid, thermoplastic polyurethane, and polyethylene glycol were mechanically mixed at a mass ratio of 80:20:20, and then the premix was put into an extruder for melt blending to obtain polylactic acid-based biodegradable Degradation of shape memory materials. The screw speed of the extruder is 20r / min, and the barrel temperature is 160-180°C.

[0036] The test results show that the polylactic acid-based biodegradable shape memory material has a glass transition temperature of 46°C, a shape fixation rate of 97.8%, and a shape recovery rate of 96.3%.

[0037] The above-mentioned polylactic acid-based biodegradable shape memory materials are used to make medical fixation devices, specifically:

[0038] (1) Granulate the polylactic acid-based biodegradable shape memory material prepared above, and use an injection molding machine to shape it into a medical fixation device.

[0039] (2) Heat the fixing device prepared in (1) to 51-66°C (5-20°C hi...

Embodiment 2

[0042] In this example, polylactic acid, thermoplastic polyurethane, and polyethylene glycol were mechanically mixed at a mass ratio of 80:20:40, and then the premix was put into an extruder for melt blending to obtain polylactic acid-based biodegradable Degradation of shape memory materials. The screw speed of the extruder is 20r / min, and the barrel temperature is 160-180°C.

[0043] The test results show that the polylactic acid-based biodegradable shape memory material has a glass transition temperature of 32°C, a shape fixation rate of 96.2%, and a shape recovery rate of 97.7%. The shape memory evolution process is as follows: Figure 1~3 shown.

[0044] The above-mentioned polylactic acid-based biodegradable shape memory materials are used to make medical fixation devices, specifically:

[0045] (1) Granulate the polylactic acid-based biodegradable shape memory material prepared above, and use an injection molding machine to mold it into a medical fixation device. At thi...

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Abstract

The invention discloses a body-heat-excited polylactic-acid-base biodegradable shape memory material, and a preparation method and application thereof. The material is composed of the main components polylactic acid and thermoplastic elastomer in a mass ratio of (70-90):(30-10), and also composed of 10-40 phr of plasticizer. The preparation method comprises the following steps: mechanically mixing the main components into a premix, adding into an extruder, and carrying out melt blending to obtain the shape memory material. The shape memory material is used for manufacturing fixers for medical treatment. The shape recovery temperature of the polylactic-acid-base biodegradable shape memory material can be adjusted to near body temperature, thereby implementing the body-heat-excited effect. The shape memory material can be better applied to biological medical materials to greatly enhance the market competitiveness of the product.

Description

technical field [0001] The invention relates to the field of biomedical polymer materials, in particular to a polylactic acid-based biodegradable shape memory material excited by body heat, a preparation method and application thereof. Background technique [0002] Biodegradable shape memory polymer material is a new type of material with biocompatibility, biodegradability and shape memory function. Biodegradable shape memory polymer materials can be deformed from a larger initial shape to a smaller temporary shape, implanted into the human body through a narrow channel, and then stimulate its shape memory effect, and the shape returns to the original state, which can be conveniently Perform many complex and difficult operations. Moreover, compared with traditional medical shape memory alloys, biodegradable shape memory polymer materials have great advantages: (1) Biodegradable, no need to be removed after surgery, which can save patients from the pain of secondary surgery:...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04C08L75/04C08L53/02C08L71/08C08K5/11C08K5/103B29C47/92B29C45/76B29C48/92
Inventor 黄汉雄于文龙
Owner SOUTH CHINA UNIV OF TECH
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