A kind of pharmaceutical composition for treating Alzheimer's disease
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A technology for Alzheimer's disease and a composition, which is applied in the field of medicine to achieve the effects of increasing ACh content, reducing pathological changes, and reducing free radical damage
Active Publication Date: 2018-01-23
南通大学技术转移中心有限公司
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[0006] The technical problem to be solved by the present invention is to combine the traditional Chinese medicine theory and the clinical characteristics of Alzheimer's disease in traditional Chinese medicine, according to the complex pathogenesis of Alzheimer's disease, aiming at its multiple pathogenesis links, to provide a drug with multi-target A traditional Chinese medicine composition that can effectively treat Alzheimer's disease
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Embodiment 1
[0030] The preparation of embodiment 1 powder
[0031] Weigh 300g of Shouwu, 300g of Ganoderma lucidum, 200g of leeches, and 200g of Anemarrhena, add water and decoct twice, the first time for 2 hours, and the second time for 1.5 hours, combine the decoctions and let stand for precipitation, filter, and put the filtrate at 80°C Concentrate under reduced pressure to form a thick paste, dry below 80°C, pulverize, and sieve to obtain extract powder, add dextrin in an appropriate amount to dry, each g extract powder contains 2.5g of crude drug, and powder is obtained after crushing, the following "Yijing" Turn into turbid powder".
Embodiment 2
[0032] The preparation of embodiment 2 capsules
[0033] Weigh 300g of Shouwu, 200g of Ganoderma lucidum, 200g of leech, and 150g of Anemarrhena, add water and decoct twice, the first time for 2 hours, and the second time for 1.5 hours, combine the decoctions and let stand for precipitation, filter, and put the filtrate at 80°C Concentrate under reduced pressure to form a thick paste, dry below 80°C, pulverize, and sieve to obtain extract powder, add appropriate amount of auxiliary materials to dry, pulverize and put into gelatin capsules.
Embodiment 3
[0034] The preparation of embodiment 3 tablet
[0035] Weigh 100g of Shouwu, 100g of Ganoderma lucidum, 100g of leeches, and 150g of Anemarrhena, add water and decoct twice, the first time for 2 hours, and the second time for 1.5 hours, combine the decoctions and let stand for precipitation, filter, and put the filtrate at 80°C Concentrate under reduced pressure to form a thick paste, dry below 80°C, pulverize, and sieve to obtain extract powder, add appropriate amount of auxiliary materials, and press into tablets.
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Abstract
The invention discloses a pharmaceutical composition for treating Alzheimer's disease, which is prepared from the following raw materials in parts by weight: 1-5 parts of Shouwu, 1-5 parts of Ganoderma lucidum, 1-2 parts of leech, 1 part of Anemarrhena ‑2 servings. The present invention combines traditional Chinese medicine theory with clinical features of Alzheimer's disease (AD) and pharmacological research methods to formulate prescriptions. Pharmacological research shows that the pharmaceutical composition of the present invention has multi-component, multi-target, Features of multiple pathways. The pharmaceutical composition of the present invention can significantly improve the learning and memory abilities of various AD rats and mouse models; it has obvious anti-inflammation to AD models; it can reduce free radical damage; it can improve energy metabolism disorders in the brain; it can obviously inhibit the hippocampus of AD rats Neuronal apoptosis rate, play a role in central cholinergic neuroprotection and anti-dementia.
Description
technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine composition and its application for treating Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD) is a degenerative disease of the central nervous system clinically characterized by progressive memory loss and dementia. With the extension of human life span, the incidence of AD has risen sharply. Due to the lack of effective treatment, AD has become the No. 4 killer of human beings after heart disease, cerebrovascular disease and cancer. Therefore, finding and developing drugs for the prevention and treatment of AD has become an urgent task, and research on the prevention and treatment of AD has become the primary research topic in the global medical community. [0003] The pathological features of AD are mainly senile plaques (senile plaques, SP), neurofibrillary tangles (neurofibrillary tangles, NFT) and neuro...
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