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A kind of soft capsule glue method

A technology of soft capsules and gelatinization, which is applied in the direction of capsule delivery and non-active ingredients of polymer compounds, etc. It can solve the problems of increasing quality hidden dangers, deformation, and affecting the quality of rubber, and achieves the effects of reducing production investment, uniform melting, and stable rubber.

Active Publication Date: 2017-10-10
BY HEALTH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Glue use process: Sometimes there is cotton-like hard glue, which often affects the quality of the rubber. If you don’t pay attention, you will produce a large number of deformed and oil-leaking balls, which increases a lot of quality hidden dangers in operation.

Method used

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  • A kind of soft capsule glue method
  • A kind of soft capsule glue method
  • A kind of soft capsule glue method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 glue method

[0032] Rubber formula:

[0033] Name of raw material

per capsule (g)

1 million grains (kg)

Gelatin (Bovine Bone Glue, 150LB)

0.2342

234.16

glycerin

0.0950

94.96

Titanium dioxide

0.0097

9.70

purified water

0.2190

219.03

[0034] Put in the formula amount of purified water, put in the formula amount of glycerin, stir for 1-2 minutes, add gelatin, stir and heat for about 60 minutes, wait until the temperature of the plastic tank reaches 74°C (heating speed is 0.7°C / min.), start pumping first Empty until no air bubbles come up above the glue (vacuumize at a negative pressure of -0.075 for 20 minutes). Turn off the vacuum valve, stop vacuuming, keep the negative pressure in the tank at -0.075MPa and cook for 25 minutes, (if the colored glue is melted, break the vacuum, add the pigment for 2 minutes) open the vacuum valve for the second vacuuming, the vacuum degree is control...

Embodiment 2

[0036] Embodiment 2 glue method

[0037] Rubber formula:

[0038] Name of raw material

per capsule (g)

1 million grains (kg)

Gelatin (Bovine Bone Glue, 150LB)

0.2201

220.05

glycerin

0.0950

94.96

[0039] Titanium dioxide

0.0097

9.70

purified water

0.2328

232.80

[0040] Put in the formula amount of purified water, put in the formula amount of glycerin, add gelatin after stirring for 1-2 minutes, stir and heat for about 50 minutes, wait until the temperature of the plastic tank reaches 76°C (heating speed is 0.9°C / min), start pumping for the first time Empty until no bubbles come up above the glue (vacuumize for 15min under negative pressure of -0.08MPa. Turn off the vacuum valve, keep the negative pressure in the tank at -0.08MPa~ and vacuumize for 20min, (colored glue, broken Vacuum, 2 minutes after adding the pigment), open the vacuum valve for the second vacuuming, the vacuum degree is contro...

Embodiment 3

[0042] Embodiment 3 glue method

[0043] Rubber formula:

[0044] Name of raw material

per capsule (g)

1 million grains (kg)

Gelatin (Bovine Bone Glue, 150LB)

0.24

240.16

glycerin

0.09

90.00

Titanium dioxide

0.009

9.00

purified water

0.2400

240.03

[0045] Put in the formula amount of purified water, put in the formula amount of glycerin, add gelatin after stirring for 1-2 minutes, stir and heat for about 50 minutes, wait until the temperature of the plastic tank reaches 76°C (heating speed is 0.8°C / min.), start pumping first Empty until no air bubbles come up above the glue (vacuumize under the negative pressure of -0.078MPa for 18min). Turn off the vacuum valve, stop vacuuming, keep the negative pressure in the tank at -0.078MPa and cook for 23 minutes, (melt the colored glue, break the vacuum, add the pigment for 2 minutes) open the vacuum valve for the second vacuuming, and the vacuum degree is cont...

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Abstract

The invention relates to the field of medicines, in particular to a gelation method for soft capsules. By controlling the contact time, initial contact temperature and heating speed of gelatin and water, the method makes the melting of gelatin more uniform. It is proved by use that the glue produced by the present invention is very stable in the production process without affecting the quality. Viscosity comparison shows that the viscosity is increased by 15% under the same formula; based on the glue solution with the same viscosity, gelatin accounts for 42% according to the glue solution ratio, which can reduce the gelatin input by 6.3%.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a soft capsule gelation method. Background technique [0002] Capsule shells are mainly used in medicine and pharmaceutical industries. Medical hollow capsules are mainly used to hold solid medicines, such as self-made powders, health care products, pharmaceuticals, etc. The capsule shell solves the problems of difficult mouth and poor taste for users, and truly solves the problem that good medicines no longer taste bad. The capsule shell is an egg-shaped hollow shell for containing solid powder and granules, which is made of food-grade pharmaceutical gelatin through refined treatment and auxiliary materials. The capsule shell has good bioavailability and dissolves quickly, reliably and safely. [0003] Edible gelatin is widely used in many food products such as puddings, sweets, preserves, chewable candies, icing, food cans and dips. In food, gelatin can help food coagulate, thicken,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/42
Inventor 符美学李太适杨帆何玉莲
Owner BY HEALTH CO LTD