A compound preparation of traditional Chinese medicine probiotics for preventing and treating respiratory diseases of broilers

A technology of compound preparations and probiotics, which can be applied to respiratory diseases, drug combinations, and medical preparations containing active ingredients. It can solve the problems of high price, slow curative effect of traditional Chinese medicine, and limited types, so as to avoid infection and promote absorption. And use, solve the effect of slow onset

Active Publication Date: 2017-06-27
山东宝来利来生物工程股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, the types of traditional Chinese medicine products used to treat broiler respiratory infectious diseases are limited and expensive, and once a respiratory disease breaks out, the curative effect of traditional Chinese medicine is slow, so it is not favored by farmers

Method used

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  • A compound preparation of traditional Chinese medicine probiotics for preventing and treating respiratory diseases of broilers
  • A compound preparation of traditional Chinese medicine probiotics for preventing and treating respiratory diseases of broilers
  • A compound preparation of traditional Chinese medicine probiotics for preventing and treating respiratory diseases of broilers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: the isolation of pathogenic bacteria

[0040] 1. Test material:

[0041] 1.1 Disease material: The larynx, trachea, air sac, and lungs of chickens suffering from respiratory diseases around Tai'an City were aseptically collected.

[0042] 1.2 Media: Normal Nutrient Broth Agar Medium (NA), Blood Agar Medium, Eosin-Maylan Agar Medium (EMB), Tryptone Soy Agar Medium (TSA), Tryptone Soy Broth Medium (TSB ), SS medium, MacConkey medium (MAC), and chocolate agar medium, all of which were purchased from Qingdao Haibo Company.

[0043] 0.005% nicotinamide adenine dinucleotide (NAD), purchased from Beijing Land Bridge Technology Co., Ltd.

[0044] 1.3 Biochemical trace identification tubes: lactose, glucose, arginine, xylose-gelatin, MR-VP, malonate, mannitol, dulcitol semi-solid, ONPG, Simon's citrate, urease, lysate Amino acid, sterile liquid paraffin, and Kovacs' indigo matrix kit were all purchased from Qingdao Haibo Company.

[0045] 1.4 Reagents for molec...

Embodiment 2

[0088] Embodiment 2: Drug susceptibility test of traditional Chinese medicine and probiotics

[0089] 1. Test material

[0090] 1.1 Single traditional Chinese medicine: Poria, Pinellia, Anemarrhena, Campanulaceae, Fangfeng, Andrographis paniculata, Black Plum, Forsythia, Pomegranate Peel, Scutellaria, Scutellaria, Qinpi, Daqingye, Huanglian, Magnolia officinalis, Banlangen, Honeysuckle, Chai Hu, licorice, Houttuynia cordata, ephedra. The above-mentioned traditional Chinese medicines were all purchased from Wanning Pharmacy in Taishan District, Tai'an.

[0091] 1.2 Probiotics:

[0092] Bacillus: Bacillus subtilis JYM 841, Bacillus subtilis B7348.

[0093] Lactic acid bacteria: Pediococcus pentosaceae PP, Enterococcus faecalis SRG, Lactobacillus plantarum LP.

[0094] Bacillus subtilis (Bacillus subtilis) JYM841, has been preserved in China Center for Type Culture Collection on January 10, 2014, and the preservation number is CCTCC NO: M 2014012; Bacillus subtilis B7348 (Bac...

Embodiment 3

[0132] Example 3: Screening of traditional Chinese medicine probiotic compound preparation

[0133] 1. Test material

[0134] 1.1 Experimental animals: 80 1-day-old healthy broiler chickens were purchased from Taian Daewoo Breeding Plant.

[0135]1.2 Experimental diet: purchased from Taian Liuhe Feed Factory, the feed type is 510, 511. 1-21 days old were fed 510, 22-42 days old were fed 511.

[0136] 1.3 Test drugs:

[0137] Chinese medicine compound prescription F1, F2 prepared in embodiment 2;

[0138] Probiotics: Lactobacillus plantarum LP bacteria powder, Bacillus subtilis B7348 bacteria powder. The bacterial powder was provided by Shandong Baolai Lilai Biological Engineering Co., Ltd.

[0139] 1.4 Test reagents:

[0140] Serum biochemical index determination reagents: serum factor total protein (TP), albumin (ALB), urea nitrogen (BUN) kits, purchased from Kehua Biological Company.

[0141] 10% (v / v) neutral formalin fixative: anhydrous disodium hydrogen phosphate 6....

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PUM

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Abstract

The invention discloses a traditional Chinese medicine probiotic compound preparation for preventing and treating broiler respiratory diseases, which is prepared by compounding a Chinese medicine extract and a probiotic powder. The mass concentration of the Chinese medicine extract is 0.1-1g / mL. The raw materials in parts by weight are decocted with water: 14‑18 parts of black plum, 10‑14 parts of pomegranate peel, 6‑10 parts of licorice, 6‑10 parts of orange peel, 6‑10 parts of Magnolia officinalis, 2‑10 parts of Houttuynia cordata 6 parts, 2-6 parts of Forsythia, 2-6 parts of Poria cocos; the probiotics are one or two mixtures of bacillus or lactic acid bacteria, and the number of live bacteria of each probiotic in the Chinese medicine probiotic compound preparation is equal to It is 105cfu / mL‑109cfu / mL. The invention also discloses a preparation method of the traditional Chinese medicine probiotic compound preparation. The traditional Chinese medicine probiotic compound preparation of the present invention is a reasonable compatibility of traditional Chinese medicine and probiotic bacteria, wherein the traditional Chinese medicine can promote the proliferation of probiotic bacteria, the probiotic bacteria can promote the absorption and utilization of traditional Chinese medicine, and the compound use of traditional Chinese medicine and probiotic bacteria can play a better role in prevention and treatment. Effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine probiotic compound preparation for preventing and treating respiratory diseases of broilers. Background technique [0002] Poultry respiratory disease has always been a thorny problem in the poultry industry, and it almost occurs in intensive poultry farms in many areas of our country, seriously affecting the economic benefits of the poultry industry. The disease mainly manifests as respiratory symptoms, with a high incidence rate, long course of disease, fast transmission speed, and easy recurrence. Take broiler chickens as an example. Respiratory diseases in broilers will reduce the feed utilization rate of chickens. Although they can be controlled with medication, it is difficult to cure them. Therefore, respiratory diseases are a type of disease that cannot be ignored in poultry production. At present, the treatment of poultry respiratory diseases mainly relies on various western medicines, t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/78A61P11/00A61K35/742A61K35/744
Inventor 单宝龙陈雷谷巍孙明杰张建梅王红崔斌林显华王军王丽荣秦波王春凤
Owner 山东宝来利来生物工程股份有限公司
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