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Pharmaceutical application of andrographis paniculata aqueous extract

A technology of Andrographis paniculata water extract and medicine, which is applied in anti-infective medicine, medicine combination, and resistance to vector-borne diseases, etc. It can solve the problems of medicine residues and side effects, and achieve the effect of low cost, simple preparation and good effect

Active Publication Date: 2015-06-17
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But as an antibiotic, long-term use of fumagillin in bee colonies can lead to drug residue problems in bee products
A large number of studies have shown that fumagillin has side effects in the treatment of human encephalitic microsporidiosis and cancer

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Weigh 10 g of Andrographis paniculata stems dried at room temperature, add 150 ml of cold water, completely immerse the Andrographis paniculata medicinal material, let it stand at room temperature for 2 hours, first boil it over high heat and then boil it gently for 40 minutes, then filter to get the filtrate. Then add 100 ml of cold water to the filtered residue, repeat the above ultrasonic steps, take the filtrate, combine the two filtrates, and keep them sealed at low temperature. Get a certain amount of Andrographis paniculata water extract and 70% sucrose syrup to prepare the Andrographis paniculata water extract syrup mixture with a mass volume ratio of 5%, and allow the bees infected with Microsporidia to feed freely.

[0011] Results: On the 7th day and 13th day after infection, the number of microsporidian spores in the experimental group was 53.8% and 29.7% of that in the untreated group, respectively, and on the 21st day after infection, the survival r...

Embodiment 2

[0013] Weigh 10 g of Andrographis paniculata stems dried at room temperature, add 150 ml of cold water, completely immerse the Andrographis paniculata medicinal material, let it stand at room temperature for 2 hours, first boil it over high heat and then boil it gently for 40 minutes, then filter to get the filtrate. Then add 100 ml of cold water to the filtered residue, repeat the above ultrasonic steps, take the filtrate, combine the two filtrates, and keep them sealed at low temperature. Get a certain amount of Andrographis paniculata water extract and 70% sucrose syrup to prepare the Andrographis paniculata water extract syrup mixture with a mass volume ratio of 3%, and allow the bees infected with Microsporidia to feed freely.

[0014] Results: On the 7th day and 13th day after infection, the number of Microsporidia spores in the experimental group was 64.5% and 29.1% of that in the untreated group, respectively. On the 21st day after infection, the survival r...

Embodiment 3

[0016] Weigh 10 g of Andrographis paniculata stems dried at room temperature, add 150 ml of cold water, completely immerse the Andrographis paniculata medicinal material, let it stand at room temperature for 2 hours, first boil it over high heat and then boil it gently for 40 minutes, then filter to get the filtrate. Then add 100 ml of cold water to the filtered residue, repeat the above ultrasonic steps, take the filtrate, combine the two filtrates, and keep them sealed at low temperature. Take a certain amount of Andrographis paniculata water extract and 70% sucrose syrup to prepare the Andrographis paniculata water extract syrup mixture with a mass volume ratio of 2%, and allow the bees infected with Microsporidia to feed freely.

[0017] Results: On the 7th day and 13th day after infection, the number of Microsporidia spores in the experimental group was 55.7% and 47.5% of that in the untreated group, respectively. On the 21st day after infection, the survival ...

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Abstract

The invention provides application of andrographis paniculata aqueous extract in preparation of drugs for preventing and treating microsporidiosis of honeybees. The andrographis paniculata aqueous extract provided by the invention is prepared into an andrographis paniculata aqueous extract syrup mixture with a certain concentration, and is loaded into a feeding machine, so that honeybees which are infected by microsporidia can eat freely, and the andrographis paniculata aqueous extract in the mixture can act on the honeybees and the microsporidia, therefore, the effect of effectively preventing and treating the microsporidiosis of honeybees can be achieved. The andrographis paniculata aqueous extract is non-poisonous to honeybees, and has a good prevention and treatment effect on the microsporidiosis of honeybees. The andrographis paniculata aqueous extract is further a natural plant extract, wide in raw materials, low in cost and easy to prepare; no pollution to honeybee products and the environment is caused, the andrographis paniculata aqueous extract is a novel drug, which is healthy, environment-friendly, ecological and efficient, for preventing and treating microsporidiosis of honeybees.

Description

technical field [0001] The invention belongs to the field of bee feeding and management, and relates to a medicine for preventing and controlling honeybee diseases, in particular to the application of an aqueous extract of Andrographis paniculata in the preparation of medicine for preventing and treating bee microsporidiosis. Background technique [0002] Honey bee microsporidiosis, also known as "bee microsporidiosis", is a common digestive tract infectious disease of adult bees caused by honey bee microsporidiosis. Microsporidium is a primitive eukaryotic parasite specializing in intracellular parasites. Microsporidium honeybee mainly destroys the normal digestive function of honeybee intestinal tract by infecting adult bee intestinal epithelial cells. When the bee colony is mildly ill, the symptoms are not obvious and are often ignored, but once it is severe, the digestive ability of the bees will be reduced, immunity and collection ability will be reduced, the life span ...

Claims

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Application Information

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IPC IPC(8): A61K36/19A61P1/00A61P33/02A61K135/00
CPCY02A50/30
Inventor 郑火青陈秀贤胡福良王帅
Owner ZHEJIANG UNIV
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