A kind of biological glass granular material and its preparation process

A bioglass and particle material technology, applied in cosmetic preparations, cosmetic preparations, dentistry, etc., can solve the problems of associated caries, affecting clinical desensitization efficiency, limited particle residual rate, etc., and achieve the effect of reducing sensitivity

Active Publication Date: 2017-03-08
DONGGUAN HONGYUAN MEDICINE TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that the particle size, particle shape and early degradation and dissolution ion composition characteristics of bioactive glass are the key factors to determine the desensitization efficiency and long-term effect, but they have been widely ignored for a long time
Careful analysis shows that the particle size of powders such as 45S5 bioglass and strontium-strengthened bioactive glass-ceramics prepared by high-temperature melting are controlled by the intensity and time of high-energy ball milling, but the particle size distribution range of ball-milled powders is wide, and there are often significantly larger than Particles with a diameter of dentin tubules (generally less than 3 microns), such coarse particles are difficult to enter the exposed dentin tubule channels during the process of treating the tooth surface with the carrier, and the residual rate of particles on the dentin surface and saliva is extremely limited during the mouthwash process , affecting its clinical desensitization efficiency
Secondly, the high-temperature molten bioglass or glass-ceramic ultrafine particles prepared by ball milling are extremely irregular in shape, especially when a large number of particles with sharp edges and corners are produced during the contact friction process of the tooth surface, the sharp and small edges and corners are easy to scratch dentin and dentine. Enamel, increasing the risk of insurmountable damage to healthy tooth surfaces
Thirdly, the fine particles of 45S5 bioglass, strontium-enhanced bioactive glass and glass ceramics contact saliva to release inorganic ions, and the resulting saliva is weakly alkaline. This intermittent increase in the pH value of oral saliva cannot effectively kill The activity of harmful microorganisms in active dental plaque, so it is difficult to achieve the desired effect in inhibiting dental plaque and dental caries; in addition, the anti-gingival bleeding effect of these conventional inorganic ion compositions also lacks basic theoretical basis
[0008] Throughout the clinical application in recent years, although a large number of special-effect desensitizing toothpastes have had positive effects on desensitization, none of them can solve clinical problems including multiple dental lesions and compound oral problems, and patients with dentin sensitivity are accompanied by dental caries and gingival bleeding. Therefore, based on the conventional bioglass that releases calcium and phosphorus ions to alleviate the problem of tooth sensitivity, it cannot fundamentally solve the accompanying oral problems.

Method used

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  • A kind of biological glass granular material and its preparation process
  • A kind of biological glass granular material and its preparation process
  • A kind of biological glass granular material and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] 1) Dissolve 2.0ml of concentrated nitric acid and 13.192ml of ethyl orthosilicate in 40ml of deionized water in turn, stir at room temperature for 30 minutes, and set aside;

[0057] 2) Add 2.859g of boric acid, 0.055g of sodium nitrate, 3.000g of potassium nitrate, 0.120g of copper nitrate, and 0.116g of zinc nitrate into the solution of step 1) in sequence, and add the two adjacent salts at an interval of 10 minutes, and stir at room temperature 10 minutes, spare;

[0058] 3) Add 12.651g of calcium nitrate, 0.286g of ammonium phosphate and 0.4g of citric acid to the solution in step 2), and stir it thoroughly for 10 minutes, then leave it to stand and age at 35°C for 72 hours, and set aside;

[0059] 4) Drying the aged gel in 3) at 120° C. for 24 hours, and then calcining at 620° C. for 90 minutes to obtain a bioglass ultrafine powder material. After determination, the contents of each oxide are: CaO 30%, SiO 2 38%,P 2 o 5 1.0%, B 2 o 3 16%, CuO 0.4%, ZnO 0.4%, ...

Embodiment 2

[0063] 1) Dissolve 1.6ml of concentrated nitric acid and 12.150ml of ethyl orthosilicate in 40ml of deionized water in turn, stir at room temperature for 60 minutes, and set aside;

[0064] 2) Add 2.680g of boric acid, 0.384g of sodium nitrate, 3.868g of potassium nitrate, 0.211g of copper nitrate, and 0.029g of zinc nitrate into the solution of step 1) in sequence, and add the two adjacent salts at an interval of 30 minutes, and stir at room temperature 30 minutes, spare;

[0065] 3) Add 11.870 g of calcium nitrate, 0.515 g of ammonium phosphate and 0.32 g of citric acid to the solution in step 2), and stir thoroughly for 45 minutes, then leave it to stand and age at 60° C. for 72 hours, and set aside;

[0066] 4) Drying the aged gel in 3) at 180° C. for 6 hours, and then calcining at 750° C. for 60 minutes to obtain a bioglass ultrafine powder material. After determination, the mass content of each oxide is: CaO 28%, SiO 2 35%,P 2 o 5 1.8%, B 2 o 3 15%, CuO 0.7%, ZnO 0...

Embodiment 3

[0068] 1) Dissolve 1.8ml of concentrated nitric acid and 12.150ml of ethyl orthosilicate in 40ml of deionized water in turn, stir at room temperature for 45 minutes, and set aside;

[0069] 2) Add 3.216g of boric acid, 1.096g of sodium nitrate, 3.868g of potassium nitrate, 0.181g of copper nitrate, and 0.058g of zinc nitrate into the solution of step 1) in sequence, and add the two adjacent salts at an interval of 15 minutes, and stir at room temperature 12 minutes, spare;

[0070] 3) Add 9.446g of calcium nitrate, 0.515g of ammonium phosphate and 0.15g of citric acid to the solution in step 2), and then fully stir for 15 minutes, then stand and age at 60°C for 48 hours, and set aside;

[0071] 4) Dry the aged gel in 3) at 150°C for 18 hours, and then calcinate at 650°C for 120 minutes to obtain a bioglass ultrafine particle powder material, and the particle size of the bioglass particles is between 250 and 1680 nanometers Between, the mass content of each oxide is: CaO 22.4%...

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Abstract

The invention discloses a bioglass granular material and a preparation technique thereof. The bioglass granular material comprises the following components in percentage by weight (represented in the form of oxides): 20-35% of CaO, 20-38% of SiO2, 0.4-1.8% of P2O5, 12-18% of B2O3, 0.1-0.8% of CuO, 0-0.7% of ZnO, 8.5-18.0% of K2O and 0.2-4.0% of Na2O. The preparation method comprises the following steps: preparing a gel, drying and calcining to obtain the bioglass granular material. The bioglass granular material can induce remineralization and total closing of dentinal tubules; the granular surface layer can be quickly degraded under the action of saliva in the oral cavity and can release multiple physiologically necessary inorganic metals and acid ions for the human body; and the inorganic ion composition can quickly inhibit the activity of harmful bacteria of the oral cavity and relieve the allergy of the dental pulp sensitive nerves to the external stimulation, thereby having great popularization and practical values.

Description

technical field [0001] The invention relates to a biologically active inorganic ultrafine particle material for alleviating human tooth sensitivity and sealing dentin tubules, and belongs to the technical field of biological materials. Background technique [0002] In 1969, Professor Larry L. Hench of the University of Florida in the United States first discovered a compound composed of CaO and SiO 2 ,P 2 o 5 and Na 2 The glass powder fired from the compound of the O component induces the deposition of bone-like apatite in the body fluid or simulated body fluid, and can form a bone chemical bond with the living bone tissue, and develop into a bone repair material for clinical application (trade name: 45S5 ). The discovery and application of this material has given people a new understanding of the connotation of bioactivity and the design of bioactive materials. So far, people have found many calcium-silicon (CaO-SiO 2 )-based amorphous glass and glass-ceramic materi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C03C3/066A61K8/27A61K8/25A61Q11/00
CPCA61K8/19A61K8/24A61K8/25A61K8/27A61Q11/00C03C4/0021C03C12/00
Inventor 李祥永苟中入彭连生杨贤燕
Owner DONGGUAN HONGYUAN MEDICINE TECH
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