A coronary artery occlusion reperfusion device and method for making animal model of myocardial infarction
A technology of coronary arteries and barriers, which is applied in veterinary instruments, veterinary surgery, medical science, etc., can solve the problems of lack of control in each link of the experiment, large individual variation, and high cost, and achieve simple and ingenious modeling process with excellent results. The effect of stabilizing and improving the success rate of the model
Active Publication Date: 2016-12-07
JOINN LAB (SUZHOU) INC
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Problems solved by technology
Animals such as cynomolgus monkeys and miniature pigs are the preferred animals for myocardial infarction models because of their advantages in physiology and pathology. However, in the construction of ischemia-reperfusion models of large animals, anesthetized animals are currently used. , high mortality rate, complicated operation, large individual variation
It is often necessary to use imaging equipment, resulting in higher costs, and at the same time, there is a lack of control in all aspects of the experiment
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[0019] The following will clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.
[0020] see Figure 1 to Figure 3 , the embodiment of the present invention includes:
[0021] A reperfusion device for coronary artery occlusion, comprising a sleeve 1 and a tether 2. One end of the sleeve 1 is a ligation end 3 , and the other end is a control end 4 . The ligation end 3 is designed in a smooth concave shape, and the end surface is polished and polished to remove acute angles under a high-power microscope to form a properly curved surface, so as to ensure that it will not damage the vessel wall when...
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The invention discloses a coronary artery blocking refilling device. The coronary artery blocking refilling device comprises a casing pipe and a tether, wherein one end of the casing pipe is a ligation end, the other end of the casing pipe is a control end, the ligation end is in a smooth concave shape, a blocking object is arranged at the opening of the ligtation end, the opening of the control end is provided with a fixture and a device capable of sealing the opening of the control end, the inner side face of the casing pipe is in a wedge shape, the inner diameter of the ligation end is smaller than that of the control end, and the tether penetrates through the casing pipe. A method for manufacturing a myocardial infarction animal model is the manufacturing method with the coronary artery blocking refilling device used. In this way, according to the coronary artery blocking refilling device and the method for manufacturing the myocardial infarction animal model, a model applicable to ischemia refilling myocardial infarction pharmacodynamics evaluation can be built on a large experimental animal highly similar to the coronary artery of the human body, and the method which is simple, is easy to implement, can be widely popularized, can really simulate the ischemia refilling generation process, is controllable in each step, stable in model and can effectively reduce the individual difference is developed.
Description
technical field [0001] The invention relates to the field of making animal models, in particular to a coronary artery occlusion reperfusion device and a method for making an animal model of myocardial infarction by using the coronary artery occlusion reperfusion device. Background technique [0002] Cardiovascular disease is currently the first type of disease that causes fatal diseases in the world. Myocardial ischemic infarction is an important symptom of cardiovascular disease, and heart failure and death from myocardial infarction are the final results of many cardiovascular diseases. Myocardial infarction caused by ischemia-reperfusion exists widely in patients with angina pectoris and patients recovering from cardiac surgery, and it is an important way of myocardial infarction. How to accurately simulate the clinical ischemia-reperfusion myocardial infarction model is an important issue in the development of new drugs. Animals such as cynomolgus monkeys and miniature ...
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IPC IPC(8): A61D1/00
CPCA61D1/00
Inventor 张海飞吴东凯北岛俊一郭卯毋孙云霞左从林
Owner JOINN LAB (SUZHOU) INC