Novel application of vinblastine and its analogue

A technology of vinblastine and substances, which is applied to the new application field of vinblastine substances, can solve problems such as studies that have not yet been reported, and achieve the effects of significant differences in efficacy and good efficacy.
CN104740602AActive Publication Date: 2015-07-01JINAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JINAN UNIVERSITY
Publication Date
2015-07-01

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Abstract

The invention provides a novel application of a vinblastine substance, and specifically speaking, the invention provides an application of vinblastine and its analogue for preventing or treating diabetic retinopathy or rheumatoid arthritis, and especially relates to obvious effect for preventing or treating diabetic retinopathy or rheumatoid arthritis displayed by a vinblastine derivative hydrazinolyed vinblastine compound, vinblastine dipeptides and salt in vitro and vivo, wherein the hydrazinolyed vinblastine compound is the compound obtained by the vinblastine compound and hydrazine hydrate through a reaction; the vinblastine dipeptides can be the hydrazinolyed vinblastine obtained by condensation of compound formed by the vinblastine compound and hydrazine hydrate through the reaction and N-benzyloxycarbonyl dipeptides.
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Description

technical field

[0001] The present invention provides a new application of vinblastine substances, in particular, provides a new application of vinblastine and its analogues in preventing or treating diabetic retinopathy or rheumatoid arthritis. It belongs to the field of medicine. Background technique

[0002] Diabetic retinopathy is a serious complication of diabetes (Malone J I, et al. Diabetes Care. 2001, 24(3):522-526). With the continuous improvement of people's living standards, the number of diabetic patients is increasing, and the incidence of diabetic retinopathy is also increasing, which seriously affects the quality of life of diabetic patients (Ramavat P R, et al.JClin Diagn Res.2013, 7(7 ): 1387-1390). The exact pathogenesis of diabetic retinopathy is not completely clear yet, some studies suggest that the process of retinal neovascularization is involved in the process of the disease (Jae-Seung Yun, et al. Diabetes Metab J.2013, 37: 262-269) . In recent ye...

Claims

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