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Use of dencichine

A technology of notoginseng and uses, applied in the field of medicine, can solve problems such as recurrent attacks, achieve the effects of improving weight loss and good application prospects

Inactive Publication Date: 2015-07-15
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, sulfasalazine, 5-aminosalicylic acid (5-ASA) sustained-release dosage forms, and corticosteroids are still the main drugs for clinical treatment of ulcers, and patients often need long-term medication maintenance, often recurrent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1. Experimental materials

[0044] 1.1 Medicinal materials

[0045] Notoginseng (CAS: 7554-90-7, MW176.13, HPLC purity ≥ 98%, Chengdu Master Biological Technology Co., Ltd.); Dextran sodium sulfate (DSS, CAS: 9011-18-1, MW36- 50kDa, produced by MP Biomedicals, USA); Sulfasalazine (SASP, CAS: 599-79-1, molecular weight 398.39, HPLC purity ≥ 98%, produced by Sigma-Aldrich, USA).

[0046] 1.2 Experimental animals

[0047] Balb / c female mice (8 weeks) weighing 20±2g were provided by the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine, animal qualification certificate number: SYXK (Shanghai) 2009-0069. Placed in a conventional feeding environment, free access to food and water.

[0048] 2. Experimental method

[0049] 2.1 Establishment of ulcerative colitis model

[0050] Balb / c female mice (20±2g) with uniform body weight were selected, and the internationally accepted method for modeling ulcerative colitis (Gastroenterology2002, 123:2...

Embodiment 2

[0074] The preparation of embodiment 2 tablet

[0075] Utilize conventional technique, mix following component, then directly compress tablet, prepare the pharmaceutical composition of tablet form, its formula is as follows:

[0076]

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Abstract

The invention relates to the technical field of medicine, and especially relates to a use of dencichine. The invention discloses the use of dencichine, prodrugs and pharmaceutical salts or plant extracts containing dencichine in preparation of drugs or health-care products for prevention or treatment of ulcerative colitis. The dencichine disclosed for the first time can significantly improve the experimental ulcerative colitis mice weight reduction, bloody stool, shortening of colon, tissue pathological damage and other symptoms, provides a new choice for clinical treatment of ulcerative colitis, and has a good application prospect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of notoginseng. Background technique [0002] Ulcerative colitis (UC) is a chronic non-specific inflammatory disease of the colon and rectum with unknown etiology. The main symptoms are diarrhea, mucus pus and blood, abdominal pain and tenesmus. Ulcer formation is a common and intractable disease of the digestive tract with pathological characteristics. In severe cases, there may be extraintestinal symptoms such as fever, arthritis, iritis, erythema nodosum, and serious complications such as colon bleeding, perforation, and cancer. The acute fulminant type of this disease has a high mortality rate, and the chronic persistent type is prone to canceration. It is reported that the incidence rate is 5-20 times higher than that of normal people, with an average of 3.5%-7%. The canceration rate of patients is 20% at 10 years, and 40% at 25 years or more, especially th...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61K36/258A61P1/04
Inventor 窦薇王峥涛张晶晶丁丽丽孙阿宁张二云
Owner SHANGHAI UNIV OF T C M
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