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Hemodialysis medicinal component sodium diacetate preparation method

A technology of sodium diacetate and medicinal ingredients, which is applied in the field of preparation of sodium diacetate, can solve the problems of not meeting the requirements of medicines, high chloride content, high heavy metal content, etc., to reduce medical costs, low chloride and heavy metal content, and production high rate effect

Inactive Publication Date: 2015-07-15
JIANGSU QINFEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high content of heavy metals in the raw material sodium hydroxide, it cannot meet the requirements of pharmaceuticals; the content of chloride in food additive sodium hydroxide is relatively high, and cannot meet the requirements of pharmaceuticals

Method used

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  • Hemodialysis medicinal component sodium diacetate preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Add 7Kg of medicinal sodium acetate into the reaction kettle, heat and stir, and at the same time dropwise add 5Kg of food-grade glacial acetic acid to the reaction kettle for reaction, heat after the reaction, keep the temperature at 110-120°C for 1 hour, filter while hot, and The material was transported to a cooling crystallizer, cooled to room temperature to obtain crystals, and the crystals were quickly dried to obtain 4.1Kg of sodium diacetate that meets the requirements of medicine, with a yield of 56%.

[0026] The products have been tested to meet the enterprise standards.

Embodiment 2

[0028] Add 7Kg of medicinal sodium acetate into the reaction kettle, heat and stir, and at the same time add 4.1Kg of food-grade glacial acetic acid dropwise to the reaction kettle for reaction. After the reaction is completed, heat, keep the temperature at 110-120°C and reflux for 1.5h, and filter while it is hot , transport the material to a cooling crystallizer, cool to room temperature, obtain crystals, and dry the crystals quickly to obtain 4.2Kg of sodium diacetate that meets the requirements of medicine, with a yield of 57%.

[0029] The products have been tested to meet the enterprise standards.

Embodiment 3

[0031] Add 7Kg of medicinal sodium acetate into the reaction kettle, heat and stir, and at the same time add 7.5Kg of food-grade glacial acetic acid dropwise to the reaction kettle for reaction. After the reaction is completed, heat, keep the temperature at 110-120°C and reflux for 2 hours, and filter while it is hot. The material was transported to a cooling crystallizer, cooled to room temperature, crystallization was obtained, and the crystallization was quickly dried to obtain 3.95Kg of sodium diacetate suitable for medicinal use, with a yield of 54%.

[0032] The products have been tested to meet the enterprise standards.

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Abstract

The present invention discloses a hemodialysis medicinal component sodium diacetate preparation method, which comprises: (1) adding a raw material drug sodium acetate to a reaction kettle, heating while stirring, and adding food grade glacial acetic acid to the reaction kettle in a dropwise manner to react, wherein a molar ratio of the medical sodium acetate to the food grade glacial acetic acid is 1:(1.1-2.0); and (2) after completing the reaction, heating to a temperature of 110-120 DEG C, carrying out reflux for 1-2 h, filtering while hot, cooling to a room temperature to obtain a crystal, and rapidly drying the crystal to obtain the medicinal sodium diacetate. According to the present invention, the prepared sodium diacetate meets the medicinal standard, the product is the solid, has characteristics of easy transportation, easy storage and risk reducing, and can be used for hemodialysis powder preparation.

Description

technical field [0001] The invention relates to a preparation method of sodium diacetate, a medicinal component for hemodialysis, and belongs to the technical field of sodium diacetate preparation. Background technique [0002] Sodium diacetate is a food additive, commonly known as solid acetic acid. It was used for food and feed preservation in the United States in the 1980s. my country began to use sodium diacetate as a food and feed additive in the 1990s, and introduced the corresponding National standard. [0003] Except as above-mentioned food and feed additive, sodium diacetate can also be applied in the field of medical treatment and pharmacy, such as being applied as one of raw materials for the preparation of hemodialysis powder, the raw material of acetic acid used in the existing acetic acid type hemodialysis powder is liquid acetic acid, Packaging and transportation are inconvenient, easy to volatilize, and glacial acetic acid is dangerous, so it is a very good w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C53/10C07C51/41
CPCC07C51/412
Inventor 梁全超顾小强丁雯雯
Owner JIANGSU QINFEN PHARMA
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