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Method for constructing food-borne hyperoxaluric calcium oxalate calculus model

A construction method and calcium oxalate technology are applied in the field of construction of food-derived calcium oxalate calculus model with excessive oxalate, which can solve the problems of poor stone-forming effect and large renal function damage, achieve good effect, high modeling success rate, Improved safety and reproducible effects

Inactive Publication Date: 2015-08-19
SICHUAN AGRI UNIV
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Problems solved by technology

[0004] At present, experimental animal models of urinary stones are mostly established on male rats. The main method is to give rats oxalic acid or oxalic acid precursors, supplemented by other inducements, such as high-calcium diet, VitB6-deficient diet, VitD diet, Foreign matter, a large amount of antibiotics, etc., to promote the formation of kidney and bladder stones in rats, but there are still disadvantages of relatively large damage to kidney function and poor stone formation effect

Method used

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  • Method for constructing food-borne hyperoxaluric calcium oxalate calculus model
  • Method for constructing food-borne hyperoxaluric calcium oxalate calculus model
  • Method for constructing food-borne hyperoxaluric calcium oxalate calculus model

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Embodiment 1

[0027] 1.1 Experiment and grouping

[0028] Select 18 male beagle dogs with a body weight of 9±0.5Kg and a dog age of 1.5-2.0 years, and be immunized with the canine pentavalent vaccine. One week later, the dogs were randomly divided into three groups: A, B, and C. The pre-test period was 7 days, fed with basic dog food, and entered the test period after the pre-test period. Regular and quantitative feeding of commercial dog food, not limited to water. All dogs had the same environmental conditions, basic dog food (see the table for its nutritional level and formula), and feeding management before and after the test. The basic dog food adopts common dog food and is added with 1.0wt% carboxymethyl chitosan. Crude protein ≤ 22%, crude fat ≤ 8%, crude fiber ≤ 3%, moisture ≤ 8%, calcium 1.2%, ash content ≤ 8%, phosphorus ≤ L1, W-3.6 among the main nutrients in the basic dog food .9≤2.7%, table salt≤0.5%, oxalic acid≥0.2%. Group A is a blank control group, feeding basic dog foo...

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Abstract

The invention relates to a method for constructing a food-borne hyperoxaluric calcium oxalate calculus model, which belongs to the technical field of animal moulding. The method is characterized in that male beagle at 1.5-2.0 years old with 8-10Kg weight, a canine penton vaccine is used for immunization, basic dog food and oxalic acid are used after 7 days for moulding, the addition of oxalic acid during a moulding period accounts for 0.8-1.5wt% of the basic dog food, and the moulding time is 25-30 days. The employed food-borne moulding method can increase the security and reproducibility for moulding, the moulding success rate is high, and effect is good.

Description

technical field [0001] The invention relates to the technical field of animal models, and more specifically, the invention relates to a method for constructing a calculus model of excessive calcium oxalate from food sources. Background technique [0002] Urinary calculus is a common disease worldwide, and calcium oxalate calculi account for about 80% of urinary calculi. Mild patients may be asymptomatic, and severe patients may develop renal failure, which is life-threatening. In recent years, due to the development of endoscopic technology, some progress has been made in the surgical treatment of urinary stones. Although it is generally believed that the formation of urinary stones is caused by a combination of genetic, environmental and metabolic factors, the mechanism of urinary stone formation is still unclear. Therefore, in the basic and clinical research of urolithiasis, it is an important part to design and establish experimental animal models of urinary calculi. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/194A61P13/04
Inventor 任志华王保黄克和邓俊良彭广能左之才钟志军余树民邓惠丹邓又天
Owner SICHUAN AGRI UNIV
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